Search Results - "Levine, Beth"

Biological Functions of Autophagy Genes: A Disease Perspective by Levine, Beth, Kroemer, Guido

“…The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily…”
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Autophagy and the cell biology of age-related disease by Leidal, Andrew M., Levine, Beth, Debnath, Jayanta

“…Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence…”
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Autophagy, immunity, and microbial adaptations by Deretic, Vojo, Levine, Beth

“…Autophagy adjusts cellular biomass and function in response to diverse stimuli, including infection. Autophagy plays specific roles in shaping immune system…”
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Autophagy and the Integrated Stress Response by Kroemer, Guido, Mariño, Guillermo, Levine, Beth

“…Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic organelles or cytosolic components. This pathway can be stimulated…”
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Unveiling the roles of autophagy in innate and adaptive immunity by Deretic, Vojo, Levine, Beth

“…Cells digest portions of their interiors in a process known as autophagy to recycle nutrients, remodel and dispose of unwanted cytoplasmic constituents. This…”
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The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death by Cecconi, Francesco, Levine, Beth

“…Autophagy is important for the degradation of bulk cytoplasm, long-lived proteins, and entire organelles. In lower eukaryotes, autophagy functions as a cell…”
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Autophagy modulation as a potential therapeutic target for diverse diseases by Rubinsztein, David C., Codogno, Patrice, Levine, Beth

“…Key Points Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and…”
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Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker’s yeast fuel advances in biomedical research by Levine, Beth, Klionsky, Daniel J.

“…Autophagy is an ancient pathway in which parts of eukaryotic cells are self-digested within the lysosome or vacuole. This process has been studied for the past…”
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Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology by Levine, Beth, Liu, Rong, Dong, Xiaonan, Zhong, Qing

“…Highlights • Beclin orthologs are crucial regulators of autophagy and related membrane-trafficking pathways. • Multiple signaling pathways converge on Beclin 1…”
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Autophagy and Viruses: Adversaries or Allies? by Dong, Xiaonan, Levine, Beth

“…The autophagy pathway is an essential component of host defense against viral infection, orchestrating pathogen degradation (xenophagy), innate immune…”
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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles by Galluzzi, Lorenzo, Bravo-San Pedro, José Manuel, Levine, Beth, Green, Douglas R., Kroemer, Guido

“…Key Points Autophagy is a catabolic process through which eukaryotic cells degrade disposable, ectopic or damaged cytoplasmic material. The inhibition or…”
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JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy by Wei, Yongjie, Pattingre, Sophie, Sinha, Sangita, Bassik, Michael, Levine, Beth

“…Starvation induces autophagy to preserve cellular homeostasis in virtually all eukaryotic organisms. However, the mechanisms by which starvation induces…”
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Bcl-2 family members: Dual regulators of apoptosis and autophagy by Levine, Beth, Sinha, Sangita C., Kroemer, Guido

“…The essential autophagy protein and haplo-insufficient tumor suppressor, Beclin 1, interacts with several cofactors (Ambra1, Bif-1, UVRAG) to activate the…”
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Exercise induces autophagy in peripheral tissues and in the brain by He, Congcong, Sumpter, Jr, Rhea, Levine, Beth

“…We recently identified physical exercise as a newly defined inducer of autophagy in vivo. Exercise induced autophagy in multiple organs involved in metabolic…”
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Autophagy is Required for Dietary Restriction-Mediated Life Span Extension in C. elegans by Jia, Kailiang, Levine, Beth

“…Dietary restriction extends life span in diverse species including Canorhabditis elegans. However, the downstream cellular targets regulated by dietary…”
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Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation by Wang, Richard C., Wei, Yongjie, An, Zhenyi, Zou, Zhongju, Xiao, Guanghua, Bhagat, Govind, White, Michael, Reichelt, Julia, Levine, Beth

“…Aberrant signaling through the class I phosphatidylinositol 3-kinase (PI3K)—Akt axis is frequent in human cancer. Here, we show that Beclin 1, an essential…”
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Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart Failure by Shirakabe, Akihiro, Zhai, Peiyong, Ikeda, Yoshiyuki, Saito, Toshiro, Maejima, Yasuhiro, Hsu, Chiao-Po, Nomura, Masatoshi, Egashira, Kensuke, Levine, Beth, Sadoshima, Junichi

“…BACKGROUND—Mitochondrial autophagy is an important mediator of mitochondrial quality control in cardiomyocytes. The occurrence of mitochondrial autophagy and…”
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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice by Fernández, Álvaro F., Sebti, Salwa, Wei, Yongjie, Zou, Zhongju, Shi, Mingjun, McMillan, Kathryn L., He, Congcong, Ting, Tabitha, Liu, Yang, Chiang, Wei-Chung, Marciano, Denise K., Schiattarella, Gabriele G., Bhagat, Govind, Moe, Orson W., Hu, Ming Chang, Levine, Beth

“…Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established 1 , 2 . Here we report…”
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Beclin-1-Dependent Autophagy Protects the Heart During Sepsis by Sun, Yuxiao, Yao, Xiao, Zhang, Qing-Jun, Zhu, Min, Liu, Zhi-Ping, Ci, Bo, Xie, Yang, Carlson, Deborah, Rothermel, Beverly A, Sun, Yuxiang, Levine, Beth, Hill, Joseph A, Wolf, Steven E, Minei, Joseph P, Zang, Qun S

“…BACKGROUND:Cardiac dysfunction is a major component of sepsis-induced multiorgan failure in critical care units. Changes in cardiac autophagy and its role…”
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Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin by Wijshake, Tobias, Zou, Zhongju, Chen, Beibei, Zhong, Lin, Xiao, Guanghua, Xie, Yang, Doench, John G., Bennett, Lynda, Levine, Beth

“…Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the…”
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