Search Results - "Levina, Asya S."

High antiviral effect of TiO2·PL–DNA nanocomposites targeted to conservative regions of (−)RNA and (+)RNA of influenza A virus in cell culture by Levina, Asya S, Repkova, Marina N, Bessudnova, Elena V, Filippova, Ekaterina I, Mazurkova, Natalia A, Zarytova, Valentina F

“…Summary Background: The development of new antiviral drugs based on nucleic acids is under scrutiny. An important problem in this aspect is to find the most…”
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Non-agglomerated silicon-organic nanoparticles and their nanocomplexes with oligonucleotides: synthesis and properties by Levina, Asya S, Repkova, Marina N, Shikina, Nadezhda V, Ismagilov, Zinfer R, Yashnik, Svetlana A, Semenov, Dmitrii V, Savinovskaya, Yulia I, Mazurkova, Natalia A, Pyshnaya, Inna A, Zarytova, Valentina F

“…The development of efficient and convenient systems for the delivery of nucleic-acid-based drugs into cells is an urgent task. А promising approach is the use…”
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Substantial Antiviral Potential of Deoxyribozymes Fixed on Anatase Nanoparticles Against Influenza A Viruses in vitro and in vivo by Levina, Asya S, Repkova, Marina N, Netesova, Nina A, Ternovoi, Vladimir A, Mazurkov, Oleg Yu, Filippova, Ekaterina I, Mazurkova, Natalia A, Zarytova, Valentina F

“…Influenza A viruses (IAV) are a high threat to humanity because of a lack of proper effective antiviral drugs and resistance of viruses to existing vaccines…”
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Knockdown of different influenza A virus subtypes in cell culture by a single antisense oligodeoxyribonucleotide by Levina, Asya S, Repkova, Marina N, Mazurkova, Natalia A, Makarevich, Elena V, Ismagilov, Zinfer R, Zarytova, Valentina F

“…Highlights • A single oligonucleotide efficiently inhibited various influenza A virus (IAV) strains. • Oligonucleotide is delivered into cells in a TiO2…”
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Nanocomposites consisting of titanium dioxide nanoparticles, antisense oligonucleotides, and photoactive groups as agents for effective action on nucleic acids by Levina, Asya S., Repkova, Marina N., Mazurkov, Oleg Y., Makarevich, Elena V., Mazurkova, Natalya A., Zarytova, Valentina F.

“…Relevance. Studies on model systems have confirmed the effectiveness of antisense oligonucleotides, including those that contain photoactive groups, for the…”
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Nanoparticle-Mediated Nonviral DNA Delivery for Effective Inhibition of Influenza a Viruses in Cells by Levina, Asya S., Repkova, Marina N., Mazurkova, Natalia A., Zarytova, Valentina F.

“…Development of new antiviral nucleic acid-based drugs and the search for their efficient delivery into cells are an urgent task. We prepared the TiO2·PL-DNA…”
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SiO2 nanoparticles as platform for delivery of 3′-triazole analogues of AZT-triphosphate into cells by Vasilyeva, Svetlana V., Levina, Asya S., Li-Zhulanov, Nikolai S., Shatskaya, Natalia V., Baiborodin, Sergei I., Repkova, Marina N., Zarytova, Valentina F., Mazurkova, Natalia A., Silnikov, Vladimir N.

“…[Display omitted] A system for delivery of analogues of AZT-triphosphates (AZT*TP) based on SiO2 nanoparticles was proposed. For this purpose, a simple and…”
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High-performance method for specific effect on nucleic acids in cells using TiO2~DNA nanocomposites by Levina, Asya S., Repkova, Marina N., Ismagilov, Zinfer R., Shikina, Nadezhda V., Malygin, Ernst G., Mazurkova, Natalia A., Zinov'ev, Victor V., Evdokimov, Alexei A., Baiborodin, Sergei I., Zarytova, Valentina F.

“…Nanoparticles are used to solve the current drug delivery problem. We present a high-performance method for efficient and selective action on nucleic acid…”
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SiO2 nanoparticles as platform for delivery of nucleoside triphosphate analogues into cells by Vasilyeva, Svetlana V., Silnikov, Vladimir N., Shatskaya, Natalia V., Levina, Asya S., Repkova, Marina N., Zarytova, Valentina F.

“…A system for delivery of analogues of 2′-deoxyribonucleoside triphosphate (dNTP) based on SiO2 nanoparticles was proposed. A simple and versatile method was…”
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Site-Specific Cleavage of RNA and DNA by Complementary DNA−Bleomycin A5 Conjugates by Vorobjev, Pavel E, Smith, Janet B, Pyshnaya, Inna A, Levina, Asya S, Zarytova, Valentina F, Wickstrom, Eric

“…Bleomycin displays clinical chemotherapeutic activity, but is so nonspecifically toxic that it is rarely administered. It was therefore of interest to…”
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Delivery system for AZT-triphosphate analogues based on SiO2 nanoparticles by Vasilyeva, Svetlana V., Silnikov, Vladimir N., Shatskaya, Natalia V., Levina, Asya S., Li-Zhulanov, Nikolai S., Mazurkova, Natalia A., Govindaraju, Kasivelu

“…SiO 2 nanoparticles as platform for delivery of 3'-triazole analogues of AZT-triphosphate into cells were proposed. The results confirmed the successfulness of…”
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Oligonucleotide derivatives bearing reactive and stabilizing groups attached to C5 of deoxyuridine by Levina, Asya S, Tabatadse, David R, Khalimskaya, Ludmila M, Prichodko, Tatjana A, Shishkin, Gennadii V, Alexandrova, Ludmila A, Zarytova, Valentina P

“…Oligonucleotides bearing an aliphatic amino group at the C5-position of deoxyuridine (ULNH2TCCCA, TULNH2CCCA, ULNH2CCACTT, where L = -CH2-, -CH2OCH2CH2- or…”
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High antiviral effect of TiO 2 ·PL-DNA nanocomposites targeted to conservative regions of (-)RNA and (+)RNA of influenza A virus in cell culture by Levina, Asya S, Repkova, Marina N, Bessudnova, Elena V, Filippova, Ekaterina I, Mazurkova, Natalia A, Zarytova, Valentina F

“…The development of new antiviral drugs based on nucleic acids is under scrutiny. An important problem in this aspect is to find the most vulnerable…”
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TiO2∼DNA nanocomposites as efficient site-specific antiviral agents against influenza A virus in cell culture by Levina, Asya S., Repkova, Marina N., Zarytova, Valentina F., Mazurkova, Natalia A.

“…The development of new antiviral nucleic acid-based drugs and the search for their efficient delivery into cells are an urgent task. We developed methods of…”
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Thermodynamic Analysis of Stacking Hybridization of Oligonucleotides with DNA Template by Pyshnyi, Dmitrii V., Pyshnaya, Inna A., Levina, Asya S., Goldberg, Eugenii L., Zarytova, Valentina F., Knorre, Dmitrii G., Ivanova, Eugenia M.

“…Contiguous stacking hybridization of oligodeoxyribonucleotides with DNA as template was investigated using three types of complexes: oligonucleotide…”
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The mechanism of recognition of templates by DNA polymerases from pro- and eukaryotes as revealed by affinity modification data by Kolocheva, T I, Nevinsky, G A, Levina, A S, Khomov, V V, Lavrik, O I

“…Pt(2+)-containing derivatives of oligodeoxyribonucleotides were used to evaluate the ligand affinity to the template sites of Klenow fragment of DNA polymerase…”
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Sequence-specific chemical modification of double-stranded DNA with alkylating oligodeoxyribonucleotide derivatives by Vlassov, V V, Gaidamakov, S A, Zarytova, V F, Knorre, D G, Levina, A S, Nikonova, A A, Podust, L M, Fedorova, O S

“…Chemical modification of double-stranded (ds) DNA with alkylating oligodeoxynucleotide (oligo) derivatives, 5'-p(N-2-chloroethyl-N-methylamino) benzylamides of…”
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Conjugates of minor groove DNA binders with oligodeoxynucleotides: synthesis and properties by Levina, A S, Metelev, V G, Cohen, A S, Zamecnik, P C

“…Oligodeoxynucleotide conjugates of netropsin (Nt) and distamycin A (Dst) were synthesized, and the thermal stability of several model DNA duplexes containing…”
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Site-specific photomodification of single-stranded DNA targets by arylazide and perfluoroarylazide derivatives of oligonucleotides by Levina, A S, Tabatadze, D R, Dobrikov, M I, Shishkin, G V, Khalimskaya, L M, Zarytova, V P

“…Highly efficient site-specific photomodification of single-stranded DNA targets was achieved with oligonucleotide reagents bearing aromatic azido groups (R (R1…”
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Sequence-specific photomodification of single-stranded and double-stranded DNA fragments by oligonucleotide perfluoroarylazide derivative by Levina, A S, Tabatadze, D R, Dobrikov, M I, Shishkin, G V, Zarytova, V P

“…A highly efficient, sequence-specific photomodification of single-stranded (ss) and double-stranded (ds) DNA fragments was carried out with a…”
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