Search Results - "Levin, Steven D"

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans by Brandt, Cameron S, Baratin, Myriam, Yi, Eugene C, Kennedy, Jacob, Gao, Zeren, Fox, Brian, Haldeman, Betty, Ostrander, Craig D, Kaifu, Tomonori, Chabannon, Christian, Moretta, Alessandro, West, Robert, Xu, Wenfeng, Vivier, Eric, Levin, Steven D

“…Cancer development is often associated with the lack of specific and efficient recognition of tumor cells by the immune system. Natural killer (NK) cells are…”
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The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity by Maurer, Mark F., Lewis, Katherine E., Kuijper, Joseph L., Ardourel, Dan, Gudgeon, Chelsea J., Chandrasekaran, Siddarth, Mudri, Sherri L., Kleist, Kayla N., Navas, Chris, Wolfson, Martin F., Rixon, Mark W., Swanson, Ryan, Dillon, Stacey R., Levin, Steven D., Kimbung, Yengo Raymond, Akutsu, Masato, Logan, Derek T., Walse, Björn, Swiderek, Kristine M., Peng, Stanford L.

“…Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective…”
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Neer Award 2012: Cerebral oxygenation in the beach chair position: a prospective study on the effect of general anesthesia compared with regional anesthesia and sedation by Koh, Jason L., MD, Levin, Steven D., MD, Chehab, Eric L., MD, Murphy, Glenn S., MD

“…Background Devastating neurologic ischemic episodes, such as stroke and deafness, have occurred in patients undergoing shoulder surgery in the beach chair…”
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A role for IL-27p28 as an antagonist of gp130-mediated signaling by Hunter, Christopher A, Stumhofer, Jason S, Tait, Elia D, III, William J Quinn, Hosken, Nancy, Spudy, Björn, Goenka, Radhika, Fielding, Ceri A, O'Hara, Aisling C, Chen, Yi, Jones, Michael L, Saris, Christiaan J M, Rose-John, Stefan, Cua, Daniel J, Jones, Simon A, Elloso, Merle M, Grötzinger, Joachim, Cancro, Michael P, Levin, Steven D

“…The heterodimeric cytokine IL-27 consists of the subunits p28 and EBI3. Hunter and colleagues demonstrate that p28 acting alone can inhibit the signaling of…”
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Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F by Kuestner, Rolf E, Taft, David W, Haran, Aaron, Brandt, Cameron S, Brender, Ty, Lum, Karen, Harder, Brandon, Okada, Shannon, Ostrander, Craig D, Kreindler, James L, Aujla, Shean J, Reardon, Brian, Moore, Margaret, Shea, Pamela, Schreckhise, Randall, Bukowski, Thomas R, Presnell, Scott, Guerra-Lewis, Patricia, Parrish-Novak, Julia, Ellsworth, Jeff L, Jaspers, Stephen, Lewis, Katherine E, Appleby, Mark, Kolls, Jay K, Rixon, Mark, West, James W, Gao, Zeren, Levin, Steven D

“…The proinflammatory cytokines IL-17A and IL-17F have a high degree of sequence similarity and share many biological properties. Both have been implicated as…”
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Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains by Levin, Steven D, Evans, Lawrence S, Bort, Susan, Rickel, Erika, Lewis, Katherine E, Wu, Rebecca P, Hoover, Joseph, MacNeil, Sean, La, David, Wolfson, Martin F, Rixon, Mark W, Dillon, Stacey R, Kornacker, Michael G, Swanson, Ryan, Peng, Stanford L

“…Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets,…”
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IL-17 receptor signaling: ubiquitin gets in on the act by Levin, Steven D

“…Engagement of the interleukin-17 (IL-17) receptor complex triggers activation of the transcription factor nuclear factor kappaB (NF-kappaB). A wide array of…”
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IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens by Song, Xinyang, Zhu, Shu, Shi, Peiqing, Liu, Yan, Shi, Yufang, Levin, Steven D, Qian, Youcun

“…IL-17RE is an orphan receptor of the IL-17 receptor family. Qian and colleagues identify IL-17RE as the receptor specific for IL-17C signaling in mucosal…”
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Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin by Leonard, Warren J, Pandey, Akhilesh, Ozaki, Katsutoshi, Baumann, Heinz, Levin, Steven D, Puel, Anne, Farr, Andrew G, Ziegler, Steven F, Lodish, Harvey F

“…Signaling by type I cytokines involves the formation of receptor homodimers, heterodimers or higher order receptor oligomers. Here we report the cloning of a…”
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Engineering of stable bispecific antibodies targeting IL-17A and IL-23 by Mabry, Robert, Lewis, Katherine E., Moore, Margaret, McKernan, Patricia A., Bukowski, Thomas R., Bontadelli, Kristen, Brender, Ty, Okada, Shannon, Lum, Karen, West, James, Kuijper, Joseph L., Ardourel, Dan, Franke, Secil, Lockwood, Luann, Vu, Tuyen, Frank, Amanda, Appleby, Mark W., Wolf, Anitra, Reardon, Brian, Hamacher, Nels B., Stevens, Brenda, Lewis, Patsy, Lewis, Kenneth B., Gilbertson, Debra G., Lantry, Megan, Julien, Susan H., Ostrander, Craig, Chan, Chung, Byrnes-Blake, Kelly, Brody, Jennifer, Presnell, Scott, Meengs, Brent, Levin, Steven D., Snavely, Mark

“…Bispecific antibodies (bsAbs) present an attractive opportunity to combine the additive and potentially synergistic effects exhibited by combinations of…”
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Cutting edge: TIGIT has T cell-intrinsic inhibitory functions by Joller, Nicole, Hafler, Jason P, Brynedal, Boel, Kassam, Nasim, Spoerl, Silvia, Levin, Steven D, Sharpe, Arlene H, Kuchroo, Vijay K

“…Costimulatory molecules regulate the functional outcome of T cell activation, and disturbance of the balance between activating and inhibitory signals results…”
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Biomechanical analysis of bursal-sided partial thickness rotator cuff tears by Yang, Scott, BS, Park, Hyung-Soon, PhD, Flores, Steven, MD, Levin, Steven D., MD, Makhsous, Mohsen, PhD, Lin, Fang, ScD, Koh, Jason, MD, Nuber, Gordon, MD, Zhang, Li-Qun, PhD

“…Background Treatment of partial thickness supraspinatus tendon tears is controversial with no clearly defined treatment algorithms based on severity of tears…”
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CD28 Plays a Critical Role in the Segregation of PKCθ within the Immunologic Synapse by Huang, Jianyong, Lo, Pei-Fen, Żal, Tomasz, Nicholas R. J. Gascoigne, Smith, Brian A., Levin, Steven D., Grey, Howard M.

“…The signaling pathways that lead to the localization of cellular protein to the area of interaction between T cell and antigen-presenting cell and the…”
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Biomechanical strain characteristics of soft tissue biceps tenodesis and bony tenodesis by Levin, Steven D., Wellman, David S., Li, Yue, Ren, Yupeng, Liu, Charley, Zhang, Li-Qun, Shah, Nirav A.

“…Biomechanical analysis of biceps tenodesis procedures has historically focused on load to failure models. Minimal data exists for the analysis of biomechanical…”
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Requirement for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction by Isaksen, Deborah E, Baumann, Heinz, Trobridge, Patty A, Farr, Andrew G, Levin, Steven D, Ziegler, Steven F

“…Thymic stromal lymphopoietin (TSLP) is a newly identified cytokine that uniquely promotes B lymphopoiesis to the B220+/IgM+ immature B cell stage. In addition,…”
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Uncoupling of Proliferation and Stat5 Activation in Thymic Stromal Lymphopoietin-Mediated Signal Transduction by Isaksen, Deborah E, Baumann, Heinz, Zhou, Baohua, Nivollet, Sebastien, Farr, Andrew G, Levin, Steven D, Ziegler, Steven F

“…Thymic stromal lymphopoietin (TSLP) is a cytokine that facilitates B lymphocyte differentiation and costimulates T cells. Previous studies have demonstrated…”
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Vstm3 is a member of the CD28 family and an important modulator of T‐cell function by Levin, Steven D., Taft, David W., Brandt, Cameron S., Bucher, Christoph, Howard, Edward D., Chadwick, Eric M., Johnston, Janet, Hammond, Angela, Bontadelli, Kristen, Ardourel, Daniel, Hebb, LuAnn, Wolf, Anitra, Bukowski, Thomas R., Rixon, Mark W., Kuijper, Joseph L., Ostrander, Craig D., West, James W., Bilsborough, Janine, Fox, Brian, Gao, Zeren, Xu, Wenfeng, Ramsdell, Fred, Blazar, Bruce R., Lewis, Katherine E.

“…Members of the CD28 family play important roles in regulating T‐cell functions and share a common gene structure profile. We have identified VSTM3 as a protein…”
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Non‐Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN‐101) by Dillon, Stacey R., Evans, Lawrence S., Lewis, Katherine E., Debrot, Susan, Blair, Tiffany C., Mudri, Sherri, Kleist, Kayla, Levin, Steven D., Bhandari, Janhavi G., Garrett, Logan, Wolfson, Martin F., Holland, Pamela M., Rixon, Mark W., Peng, Stanford L.

“…Objective CD28 and inducible T cell costimulator (ICOS) appear to have nonredundant roles in T cell activation and adaptive immunity. We undertook this study…”
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Strain effects of placing an arthroscopic portal through the subscapularis tendon by Khan, Najeeb, MD, Levin, Steven D., MD, Domont, Zachary B., MD, Wu, Yi-Ning, PhD, Ren, Yupeng, MS, Zhang, Li-Qun, PhD

“…Hypothesis The biomechanical effects of placing a portal through the subscapularis tendon have not been studied. Our hypothesis is that placing a portal…”
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Shoulder arthroscopy in patients with a cardiac pacemaker or defibrillator: A case report and discussion of perioperative management by Wellman, David S., MD, McCoy, Brett W., MD, Levin, Steven D., MD, Knight, Bradley P., MD

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