Search Results - "Levin, B. R."

Phenotypic Tolerance: Antibiotic Enrichment of Noninherited Resistance in Bacterial Populations by WIUFF, C, ZAPPALA, R. M, REGOES, R. R, GARNER, K. N, BAQUERO, F, LEVIN, B. R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Episodic Selection and the Maintenance of Competence and Natural Transformation in Bacillus subtilis by Johnsen, P. J, Dubnau, D, Levin, B. R

“…We present a new hypothesis for the selective pressures responsible for maintaining natural competence and transformation. Our hypothesis is based in part on…”
Get full text

Minimizing Potential Resistance: A Population Dynamics View by Levin, Bruce R.

“…I examine the results of studies that used mathematical models of the epidemiology and population genetics of antibiotic treatment and resistance in open…”
Get full text

The population dynamics of antimicrobial chemotherapy by LIPSITCH, M, LEVIN, B. R

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
Get full text

The Population Genetics of Antibiotic Resistance by Levin, B. R., Lipsitch, M., Perrot, V., Schrag, S., Antia, R., Simonsen, L., Moore Walker, N., Stewart, F. M.

“…Mathematical models are used to ascertain the relationship between the incidence of antibiotic treatment and the frequency of resistant bacteria in the…”
Get full text

The biological cost of antibiotic resistance by Andersson, Dan I, Levin, Bruce R

“…The frequency and rates of ascent and dissemination of antibiotic resistance in bacterial populations are anticipated to be directly related to the volume of…”
Get full text

L-735,524: An Orally Bioavailable Human Immunodeficiency Virus Type 1 Protease Inhibitor by Vacca, J. P., Dorsey, B. D., Schleif, W. A., Levin, R. B., McDaniel, S. L., Darke, P. L., Zugay, J., Quintero, J. C., Blahy, O. M., Roth, E., Sardana, V. V., Schlabach, A. J., Graham, P. I., Condra, J. H., Gotlib, L., Holloway, M. K., Lin, J., I.-W. Chen, Vastag, K., Ostovic, D., Anderson, P. S., Emini, E. A., Huff, J. R.

“…To date, numerous inhibitors of the human immunodeficiency virus type 1 protease have been reported, but few have been studied extensively in humans, primarily…”
Get full text

Adaptation to the fitness costs of antibiotic resistance in Escherichia coli by Schrag, Stephanie J., Perrot, Véronique, Levin, Bruce R.

“… Here we present evidence that these genetic adaptations to the costs of resistance can virtually preclude resistant lineages from reverting to sensitivity…”
Get full text

Population dynamics of tuberculosis treatment: mathematical models of the roles of non-compliance and bacterial heterogeneity in the evolution of drug resistance by LIPSITCH, M, LEVIN, B. R

“…Setting: Patient non-compliance and/or spatial heterogeneity in drug concentration or effectiveness may contribute to the emergence of drug resistance during…”
Get full text

Concentration-Dependent Selection of Small Phenotypic Differences in TEM β-Lactamase-Mediated Antibiotic Resistance by NEGRI, M.-C, LIPSITCH, M, BLAZQUEZ, J, LEVIN, B. R, BAQUERO, F

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Within-Host Population Dynamics and the Evolution and Maintenance of Microparasite Virulence by Antia, Rustom, Levin, Bruce R., May, Robert M.

“…We examine effects of the vertebrate immune system on the evolution and maintenance of virulence of microparasites (viruses, bacteria, or unicellular…”
Get full text

A methodology for using Lambda phages as a proxy for pathogen transmission in hospitals by Burke, K.B., Berryhill, B.A., Garcia, R., Goldberg, D.A., Manuel, J.A., Gannon, P.R., Levin, B.R., Kraft, C.S., Mumma, J.M.

“…One major concern in hospitalized patients is acquiring infections from pathogens borne on surfaces, patients, and healthcare workers (HCWs). Fundamental to…”
Get full text

Frequency-Dependent Selection in Bacterial Populations [and Discussion] by Levin, B. R., Antonovics, J., Sharma, H.

“…There are many situations in which the direction and intensity of natural selection in bacterial populations will depend on the relative frequencies of…”
Get full text

Cardiomyopathy in muscular dystrophy by Indorkar, R, Al-Yafi, M, Romano, S, Levin, B R, Farzaneh-Far, A

Get full text

L-735,524 : the design of a potent and orally bioavailable HIV protease inhibitor by DORSEY, B. D, LEVIN, R. B, LIN, J. H, CHEN, I.-W, HOLLOWAY, M. K, FITZGERALD, P. M. D, AXEL, M. G, OSTOVIC, D, ANDERSON, P. S, HUFF, J. R, MCDANIEL, S. L, VACCA, J. P, GUARE, J. P, DARKE, P. L, ZUGAY, J. A, EMINI, E. A, SCHLEIF, W. A, QUINTERO, J. C

“…A series of HIV protease inhibitors possessing a hydroxylaminepentanamide transition state isostere have been developed. Incorporation of a basic amine into…”
Get full text

Models for the spread of resistant pathogens by Levin, B R

“…I consider three mathematical models of the epidemiology of antibiotic treatment and the evolution of resistance. All of these models explore the relationship…”
Get full text

Population and evolutionary dynamics of phage therapy by Levin, Bruce R, Bull, James J

“…Following a sixty-year hiatus in western medicine, bacteriophages (phages) are again being advocated for treating and preventing bacterial infections. Are…”
Get full text

Population Biology, Evolution, and Infectious Disease: Convergence and Synthesis by Levin, Bruce R., Lipsitch, Marc, Bonhoeffer, Sebastian

“…Traditionally, the interest of population and evolutionary biologists in infectious diseases has been almost exclusively in their role as agents of natural…”
Get full text

Fluctuation Analysis: The Probability Distribution of the Number of Mutants Under Different Conditions by Stewart, F. M, Gordon, D. M, Levin, B. R

“…In the 47 years since fluctuation analysis was introduced by Luria and Delbrück, it has been widely used to calculate mutation rates. Up to now, in spite of…”
Get full text

Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria by Levin, B R, Perrot, V, Walker, N

“…In the absence of the selecting drugs, chromosomal mutations for resistance to antibiotics and other chemotheraputic agents commonly engender a cost in the…”
Get full text