Search Results - "Levi, Boaz"

CORTECON: A Temporal Transcriptome Analysis of In Vitro Human Cerebral Cortex Development from Human Embryonic Stem Cells by van de Leemput, Joyce, Boles, Nathan C., Kiehl, Thomas R., Corneo, Barbara, Lederman, Patty, Menon, Vilas, Lee, Changkyu, Martinez, Refugio A., Levi, Boaz P., Thompson, Carol L., Yao, Shuyuan, Kaykas, Ajamete, Temple, Sally, Fasano, Christopher A.

“…Many neurological and psychiatric disorders affect the cerebral cortex, and a clearer understanding of the molecular processes underlying human corticogenesis…”
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Linking connectome with transcriptome using a self-inactivating rabies virus by Yao, Shenqin, Levi, Boaz P.

“…A self-inactivating rabies virus tracer allows long-term monitoring and transcriptomic profiling of synaptically connected cells…”
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A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation by Yao, Zizhen, van Velthoven, Cindy T.J., Nguyen, Thuc Nghi, Goldy, Jeff, Sedeno-Cortes, Adriana E., Baftizadeh, Fahimeh, Bertagnolli, Darren, Casper, Tamara, Chiang, Megan, Crichton, Kirsten, Ding, Song-Lin, Fong, Olivia, Garren, Emma, Glandon, Alexandra, Gouwens, Nathan W., Gray, James, Graybuck, Lucas T., Hawrylycz, Michael J., Hirschstein, Daniel, Kroll, Matthew, Lathia, Kanan, Lee, Changkyu, Levi, Boaz, McMillen, Delissa, Mok, Stephanie, Pham, Thanh, Ren, Qingzhong, Rimorin, Christine, Shapovalova, Nadiya, Sulc, Josef, Sunkin, Susan M., Tieu, Michael, Torkelson, Amy, Tung, Herman, Ward, Katelyn, Dee, Nick, Smith, Kimberly A., Tasic, Bosiljka, Zeng, Hongkui

“…The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in perception, cognition, emotion, and learning. We profiled ∼1.3…”
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Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy by Nakada, Daisuke, Oguro, Hideyuki, Levi, Boaz P., Ryan, Nicole, Kitano, Ayumi, Saitoh, Yusuke, Takeichi, Makiko, Wendt, George R., Morrison, Sean J.

“…Haematopoietic stem cells are found to be regulated differently in male and female mice — haematopoietic stem cells in females divide more frequently than in…”
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Conserved cell types with divergent features in human versus mouse cortex by Hodge, Rebecca D., Bakken, Trygve E., Miller, Jeremy A., Smith, Kimberly A., Barkan, Eliza R., Graybuck, Lucas T., Close, Jennie L., Long, Brian, Johansen, Nelson, Penn, Osnat, Yao, Zizhen, Eggermont, Jeroen, Höllt, Thomas, Levi, Boaz P., Shehata, Soraya I., Aevermann, Brian, Beller, Allison, Bertagnolli, Darren, Brouner, Krissy, Casper, Tamara, Cobbs, Charles, Dalley, Rachel, Dee, Nick, Ding, Song-Lin, Ellenbogen, Richard G., Fong, Olivia, Garren, Emma, Goldy, Jeff, Gwinn, Ryder P., Hirschstein, Daniel, Keene, C. Dirk, Keshk, Mohamed, Ko, Andrew L., Lathia, Kanan, Mahfouz, Ahmed, Maltzer, Zoe, McGraw, Medea, Nguyen, Thuc Nghi, Nyhus, Julie, Ojemann, Jeffrey G., Oldre, Aaron, Parry, Sheana, Reynolds, Shannon, Rimorin, Christine, Shapovalova, Nadiya V., Somasundaram, Saroja, Szafer, Aaron, Thomsen, Elliot R., Tieu, Michael, Quon, Gerald, Scheuermann, Richard H., Yuste, Rafael, Sunkin, Susan M., Lelieveldt, Boudewijn, Feng, David, Ng, Lydia, Bernard, Amy, Hawrylycz, Michael, Phillips, John W., Tasic, Bosiljka, Zeng, Hongkui, Jones, Allan R., Koch, Christof, Lein, Ed S.

“…Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we…”
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Fixed single-cell transcriptomic characterization of human radial glial diversity by Thomsen, Elliot R, Mich, John K, Yao, Zizhen, Hodge, Rebecca D, Doyle, Adele M, Jang, Sumin, Shehata, Soraya I, Nelson, Angelique M, Shapovalova, Nadiya V, Levi, Boaz P, Ramanathan, Sharad

“…The Fixed and Recovered Intact Single-cell RNA (FRISCR) method enables robust RNA extraction and sequencing from fixed, stained and sorted single cells and…”
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Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis by Nakada, Daisuke, Levi, Boaz P., Morrison, Sean J.

“…Stem cells are uniquely able to self-renew, to undergo multilineage differentiation, and to persist throughout life in a number of tissues. Stem cells are…”
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Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons by Matson, Kaya J. E., Russ, Daniel E., Kathe, Claudia, Hua, Isabelle, Maric, Dragan, Ding, Yi, Krynitsky, Jonathan, Pursley, Randall, Sathyamurthy, Anupama, Squair, Jordan W., Levi, Boaz P., Courtine, Gregoire, Levine, Ariel J.

“…After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer…”
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A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system by Ghabrial, Amin S, Levi, Boaz P, Krasnow, Mark A

“…Many signaling proteins and transcription factors that induce and pattern organs have been identified, but relatively few of the downstream effectors that…”
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A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development by Yao, Zizhen, Mich, John K., Ku, Sherman, Menon, Vilas, Krostag, Anne-Rachel, Martinez, Refugio A., Furchtgott, Leon, Mulholland, Heather, Bort, Susan, Fuqua, Margaret A., Gregor, Ben W., Hodge, Rebecca D., Jayabalu, Anu, May, Ryan C., Melton, Samuel, Nelson, Angelique M., Ngo, N. Kiet, Shapovalova, Nadiya V., Shehata, Soraya I., Smith, Michael W., Tait, Leah J., Thompson, Carol L., Thomsen, Elliot R., Ye, Chaoyang, Glass, Ian A., Kaykas, Ajamete, Yao, Shuyuan, Phillips, John W., Grimley, Joshua S., Levi, Boaz P., Wang, Yanling, Ramanathan, Sharad

“…During human brain development, multiple signaling pathways generate diverse cell types with varied regional identities. Here, we integrate single-cell RNA…”
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Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network by Whitesell, Jennifer D., Liska, Adam, Coletta, Ludovico, Hirokawa, Karla E., Bohn, Phillip, Williford, Ali, Groblewski, Peter A., Graddis, Nile, Kuan, Leonard, Knox, Joseph E., Ho, Anh, Wakeman, Wayne, Nicovich, Philip R., Nguyen, Thuc Nghi, van Velthoven, Cindy T.J., Garren, Emma, Fong, Olivia, Naeemi, Maitham, Henry, Alex M., Dee, Nick, Smith, Kimberly A., Levi, Boaz, Feng, David, Ng, Lydia, Tasic, Bosiljka, Zeng, Hongkui, Mihalas, Stefan, Gozzi, Alessandro, Harris, Julie A.

“…The evolutionarily conserved default mode network (DMN) is a distributed set of brain regions coactivated during resting states that is vulnerable to brain…”
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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates by Chen, Xinhong, Wolfe, Damien A., Bindu, Dhanesh Sivadasan, Zhang, Mengying, Taskin, Naz, Goertsen, David, Shay, Timothy F., Sullivan, Erin E., Huang, Sheng-Fu, Ravindra Kumar, Sripriya, Arokiaraj, Cynthia M., Plattner, Viktor M., Campos, Lillian J., Mich, John K., Monet, Deja, Ngo, Victoria, Ding, Xiaozhe, Omstead, Victoria, Weed, Natalie, Bishaw, Yeme, Gore, Bryan B., Lein, Ed S., Akrami, Athena, Miller, Cory, Levi, Boaz P., Keller, Annika, Ting, Jonathan T., Fox, Andrew S., Eroglu, Cagla, Gradinaru, Viviana

“…Delivering genes to and across the brain vasculature efficiently and specifically across species remains a critical challenge for addressing neurological…”
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Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain by Chuapoco, Miguel R., Flytzanis, Nicholas C., Goeden, Nick, Christopher Octeau, J., Roxas, Kristina M., Chan, Ken Y., Scherrer, Jon, Winchester, Janet, Blackburn, Roy J., Campos, Lillian J., Man, Kwun Nok Mimi, Sun, Junqing, Chen, Xinhong, Lefevre, Arthur, Singh, Vikram Pal, Arokiaraj, Cynthia M., Shay, Timothy F., Vendemiatti, Julia, Jang, Min J., Mich, John K., Bishaw, Yemeserach, Gore, Bryan B., Omstead, Victoria, Taskin, Naz, Weed, Natalie, Levi, Boaz P., Ting, Jonathan T., Miller, Cory T., Deverman, Benjamin E., Pickel, James, Tian, Lin, Fox, Andrew S., Gradinaru, Viviana

“…Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the brain. Adeno-associated viruses (AAVs) promise robust, non-invasive…”
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Interindividual variation in human cortical cell type abundance and expression by Johansen, Nelson, Somasundaram, Saroja, Travaglini, Kyle J, Yanny, Anna Marie, Shumyatcher, Maya, Casper, Tamara, Cobbs, Charles, Dee, Nick, Ellenbogen, Richard, Ferreira, Manuel, Goldy, Jeff, Guzman, Junitta, Gwinn, Ryder, Hirschstein, Daniel, Jorstad, Nikolas L, Keene, C Dirk, Ko, Andrew, Levi, Boaz P, Ojemann, Jeffrey G, Pham, Thanh, Shapovalova, Nadiya, Silbergeld, Daniel, Sulc, Josef, Torkelson, Amy, Tung, Herman, Smith, Kimberly, Lein, Ed S, Bakken, Trygve E, Hodge, Rebecca D, Miller, Jeremy A

“…Single-cell transcriptomic studies have identified a conserved set of neocortical cell types from small postmortem cohorts. We extended these efforts by…”
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Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans by Bakken, Trygve E, van Velthoven, Cindy Tj, Menon, Vilas, Hodge, Rebecca D, Yao, Zizhen, Nguyen, Thuc Nghi, Graybuck, Lucas T, Horwitz, Gregory D, Bertagnolli, Darren, Goldy, Jeff, Yanny, Anna Marie, Garren, Emma, Parry, Sheana, Casper, Tamara, Shehata, Soraya I, Barkan, Eliza R, Szafer, Aaron, Levi, Boaz P, Dee, Nick, Smith, Kimberly A, Sunkin, Susan M, Bernard, Amy, Phillips, John, Hawrylycz, Michael J, Koch, Christof, Murphy, Gabe J, Lein, Ed, Zeng, Hongkui, Tasic, Bosiljka

“…Abundant evidence supports the presence of at least three distinct types of thalamocortical (TC) neurons in the primate dorsal lateral geniculate nucleus…”
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Putting Two Heads Together to Build a Better Brain by Mich, John K., Close, Jennie L., Levi, Boaz P.

“…3D organoids enable in vitro human brain development models, but they have not yet recapitulated some essential features of brain circuit formation. Recently,…”
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Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states by Jang, Sumin, Choubey, Sandeep, Furchtgott, Leon, Zou, Ling-Nan, Doyle, Adele, Menon, Vilas, Loew, Ethan B, Krostag, Anne-Rachel, Martinez, Refugio A, Madisen, Linda, Levi, Boaz P, Ramanathan, Sharad

“…The complexity of gene regulatory networks that lead multipotent cells to acquire different cell fates makes a quantitative understanding of differentiation…”
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Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems by Levi, Boaz P., Yilmaz, Ömer H., Duester, Gregg, Morrison, Sean J.

“…High levels of aldehyde dehydrogenase (ALDH) activity have been proposed to be a common feature of stem cells. Adult hematopoietic, neural, and cancer stem…”
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Single-Cell Profiling of an In Vitro Model of Human Interneuron Development Reveals Temporal Dynamics of Cell Type Production and Maturation by Close, Jennie L., Yao, Zizhen, Levi, Boaz P., Miller, Jeremy A., Bakken, Trygve E., Menon, Vilas, Ting, Jonathan T., Wall, Abigail, Krostag, Anne-Rachel, Thomsen, Elliot R., Nelson, Angel M., Mich, John K., Hodge, Rebecca D., Shehata, Soraya I., Glass, Ian A., Bort, Susan, Shapovalova, Nadiya V., Ngo, N. Kiet, Grimley, Joshua S., Phillips, John W., Thompson, Carol L., Ramanathan, Sharad, Lein, Ed

“…GABAergic interneurons are essential for neural circuit function, and their loss or dysfunction is implicated in human neuropsychiatric disease. In vitro…”
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Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress by Morrison, Sean J, Chuikov, Sergei, Levi, Boaz P, Smith, Michael L

“…To better understand the mechanisms that regulate stem cell identity and function, we sought to identify genes that are preferentially expressed by stem cells…”
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