Search Results - "Levi, Beverly"

Sphingolipids and mitochondrial apoptosis by Patwardhan, Gauri A., Beverly, Levi J., Siskind, Leah J.

“…The sphingolipid family of lipids modulate several cellular processes, including proliferation, cell cycle regulation, inflammatory signaling pathways, and…”
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Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome by Rhyasen, Garrett W., Bolanos, Lyndsey, Fang, Jing, Jerez, Andres, Wunderlich, Mark, Rigolino, Carmela, Mathews, Lesley, Ferrer, Marc, Southall, Noel, Guha, Rajarshi, Keller, Jonathan, Thomas, Craig, Beverly, Levi J., Cortelezzi, Agostino, Oliva, Esther N., Cuzzola, Maria, Maciejewski, Jaroslaw P., Mulloy, James C., Starczynowski, Daniel T.

“…Myelodysplastic syndromes (MDSs) arise from a defective hematopoietic stem/progenitor cell. Consequently, there is an urgent need to develop targeted therapies…”
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The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis by Kurlawala, Zimple, Shah, Parag P., Shah, Charmi, Beverly, Levi J.

“…ABSTRACT There are five Ubiquilin proteins (UBQLN1‐4, UBQLN‐L), which are evolutionarily conserved and structurally similar. UBQLN proteins have three…”
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UBQLN Family Members Regulate MYC in Lung Adenocarcinoma Cells by Shah, Parag P, Beverly, Levi J

“…The ubiquilin family (UBQLN) of proteins consists of five closely related members (UBQLN1, UBQLN2, UBQLN3, UBQLN4, and UBQLNL) that have a high degree of…”
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De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues by Fan, Teresa W.M., Bruntz, Ronald C., Yang, Ye, Song, Huan, Chernyavskaya, Yelena, Deng, Pan, Zhang, Yan, Shah, Parag P., Beverly, Levi J., Qi, Zhen, Mahan, Angela L., Higashi, Richard M., Dang, Chi V., Lane, Andrew N.

“…Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de novo biosynthesis are not defined in human cancer tissues. We…”
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Subclinical kidney injury induced by repeated cisplatin administration results in progressive chronic kidney disease by Sharp, Cierra N, Doll, Mark A, Megyesi, Judit, Oropilla, Gabrielle B, Beverly, Levi J, Siskind, Leah J

“…Cisplatin is used to treat many solid cancers, but its dose-limiting side effect is nephrotoxicity, causing acute kidney injury in 30% of patients. Previously,…”
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Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung by Podsypanina, Katrina, Du, Yi-Chieh Nancy, Jechlinger, Martin, Beverly, Levi J, Hambardzumyan, Dolores, Varmus, Harold

“…The acquisition of metastatic ability by tumor cells is considered a late event in the evolution of malignant tumors. We report that untransformed mouse…”
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Repeated administration of low-dose cisplatin in mice induces fibrosis by Sharp, Cierra N, Doll, Mark A, Dupre, Tess V, Shah, Parag P, Subathra, Marimuthu, Siow, Deanna, Arteel, Gavin E, Megyesi, Judit, Beverly, Levi J, Siskind, Leah J

“…Cisplatin, a chemotherapeutic used for the treatment of solid cancers, has nephrotoxic side effects leading to acute kidney injury (AKI). Cisplatin cannot be…”
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Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response by Barve, Aditya, Casson, Lavona, Krem, Maxwell, Wunderlich, Mark, Mulloy, James C., Beverly, Levi J.

“…•We provide a comparison of engraftment efficiencies in unconditioned NRG (NOD/RAG1/2−/−IL2Rγ−/−) and NRGS (NRG-SGM3) mice.•NRGS mice do not develop clinically…”
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BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins by Beverly, Levi J, Howell, Lauren A, Hernandez-Corbacho, Maria, Casson, Lavona, Chipuk, Jerry E, Siskind, Leah J

“…Determining mechanistic details about how drugs kill cancer cells is critical for predicting which cancers will respond to given therapeutic regimens and for…”
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Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity by Orwick, Andrew, Sears, Sophia M, Sharp, Cierra N, Doll, Mark A, Shah, Parag P, Beverly, Levi J, Siskind, Leah J

“…Patients with cancer represent a unique patient population with increased susceptibility to kidney disease. Drug-induced acute kidney injury (AKI) in patients…”
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Fibroblast-Derived Extracellular Matrices: An Alternative Cell Culture System That Increases Metastatic Cellular Properties by Scherzer, Michael T, Waigel, Sabine, Donninger, Howard, Arumugam, Vennila, Zacharias, Wolfgang, Clark, Geoffrey, Siskind, Leah J, Soucy, Patricia, Beverly, Levi

“…Poor survival rates from lung cancer can largely be attributed to metastatic cells that invade and spread throughout the body. The tumor microenvironment (TME)…”
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Mutant and curli-producing E. coli enhance the disease phenotype in a hSOD1-G93A mouse model of ALS by Kurlawala, Zimple, McMillan, Joseph D., Singhal, Richa A., Morehouse, Johnny, Burke, Darlene A., Sears, Sophia M., Duregon, Eleonora, Beverly, Levi J., Siskind, Leah J., Friedland, Robert P.

“…The gut microbiome is a potential non-genetic contributing factor for Amyotrophic Lateral Sclerosis. Differences in gut microbial communities have been…”
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Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress by Shah, Parag P, Dupre, Tess V, Siskind, Leah J, Beverly, Levi J

“…Endoplasmic reticulum (ER) in eukaryotes is a main organelle involved in a wide variety of functions including calcium storage, lipid biosynthesis, protein…”
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Ubiquilin proteins regulate EGFR levels and activity in lung adenocarcinoma cells by Kurlawala, Zimple, Saurabh, Kumar, Dunaway, Rain, Shah, Parag P., Siskind, Leah J., Beverly, Levi J.

“…Ubiquilin (UBQLN) proteins are involved in diverse cellular processes like endoplasmic reticulum‐associated degradation, autophagy, apoptosis, and…”
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Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury by Sears, Sophia M., Dupre, Tess V., Shah, Parag P., Davis, Deanna L., Doll, Mark A., Sharp, Cierra N., Vega, Alexis A., Megyesi, Judit, Beverly, Levi J., Snider, Ashley J., Obeid, Lina M., Hannun, Yusuf A., Siskind, Leah J.

“…Cisplatin is a commonly used chemotherapeutic for the treatment of many solid organ cancers; however, its effectiveness is limited by the development of acute…”
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Ceramide channels: destabilization by Bcl-xL and role in apoptosis by Chang, Kai-Ti, Anishkin, Andriy, Patwardhan, Gauri A., Beverly, Levi J., Siskind, Leah J., Colombini, Marco

“…Ceramide is a bioactive sphingolipid involved in mitochondrial-mediated apoptosis. Our data suggest that ceramides directly regulate a key initiation step in…”
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C57BL/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury by Sears, Sophia M, Sharp, Cierra N, Krueger, Austin, Oropilla, Gabrielle B, Saforo, Douglas, Doll, Mark A, Megyesi, Judit, Beverly, Levi J, Siskind, Leah J

“…C57BL/6 mice are one of the most commonly used mouse strains in research, especially in kidney injury studies. However, C57BL/6 mice are resistant to chronic…”
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Moderate aging does not exacerbate cisplatin-induced kidney injury or fibrosis despite altered inflammatory cytokine expression and immune cell infiltration by Sharp, Cierra N, Doll, Mark, Dupre, Tess V, Beverly, Levi J, Siskind, Leah J

“…Aging is a risk factor for certain forms of kidney injury due to normal physiological changes, but the role of aging in cisplatin-induced kidney injury is not…”
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Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis by Shah, Parag P., Saurabh, Kumar, Kurlawala, Zimple, Vega, Alexis A., Siskind, Leah J., Beverly, Levi J.

“…•The Ubiquilin family of proteins (UBQLN) consists of five related proteins (UBQLN1-4 and UBQLNL).•Herein, we showed that loss of UBQLN1 and/or UBQLN2 induces…”
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