Peanut ingestion increases rectal proliferation in individuals with mucosal expression of peanut lectin receptor

Background & Aims: The Thomsen–Friedenreich blood group antigen (galactose β1,3- N-acetyl galactosamine α-) acts as an oncofetal antigen in the colonic epithelium, with low expression in normal adult epithelia but increasing to fetal levels of expression in hyperplasia or malignancy. Peanut lect...

Full description

Saved in:

Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 114; no. 1; pp. 44 - 49
Main Authors:	Ryder, Stephen D., Jacyna, Meron R., Levi, A.Jonathon, Rizzi, Paolo M., Rhodes, Jonathan M.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 1998 Elsevier
Subjects:	Adult Aged Antigens, Tumor-Associated, Carbohydrate - metabolism Arachis - adverse effects Arachis - metabolism Biological and medical sciences Cell Division Colon - metabolism Colon - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lectins - adverse effects Male Medical sciences Middle Aged Plant Lectins Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Galβ(1-3)GalNAcα PNA TF TBS HU CI Human Peanut Lectin Concentration factor Rectal disease Carcinoma Nutrition Mitosis Cytologic investigation Hyperplasia Supplemented diet Malignant tumor Proliferation Result Colonic disease Pathology Rectum Digestive diseases Intestinal disease Colon Biological effect
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Background & Aims: The Thomsen–Friedenreich blood group antigen (galactose β1,3- N-acetyl galactosamine α-) acts as an oncofetal antigen in the colonic epithelium, with low expression in normal adult epithelia but increasing to fetal levels of expression in hyperplasia or malignancy. Peanut lectin is one of the commonest dietary lectins that binds this antigen. The aim of this study was to determine whether peanut ingestion can alter rectal epithelial proliferation. Methods: Thirty-six patients with normal colonic mucosa consumed 100 g of peanuts each day for 5 days. Rectal mitotic index was measured before and after ingestion, and changes in proliferation were correlated with immunohistochemical detection of lectin receptor expression by colonocytes and fecal lectin activity as measured by hemagglutination assay. Results: Peanut ingestion caused a 41% increase in rectal mucosal proliferation in individuals with macroscopically normal mucosa who express TF antigen in their rectal mucosae (10 of 36 patients studied). The proliferative response correlated with fecal hemagglutinating activity, and peanut lectin could be shown immunohistochemically within the rectal mucosa. Conclusions: The common expression of galactose β1,3- N-acetyl galactosamine α- by hyperplastic and neoplastic epithelia may therefore be functionally important because it allows interaction with mitogenic dietary lectins. This could be an important mechanism for the association between diet and colorectal cancer. GASTROENTEROLOGY 1998;114:44-49
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0016-5085 1528-0012
DOI:	10.1016/S0016-5085(98)70631-6