Search Results - "Leverve, Xavier"

Cytometric assessment of mitochondria using fluorescent probes by Cottet‐Rousselle, Cécile, Ronot, Xavier, Leverve, Xavier, Mayol, Jean‐François

“…Mitochondria are most important organelles in the survival of eukaryotic aerobic cells because they are the primary producers of ATP, regulators of ion…”
Get full text

ESPEN Guidelines on Parenteral Nutrition: Intensive care by Singer, Pierre, Berger, Mette M, Van den Berghe, Greet, Biolo, Gianni, Calder, Philip, Forbes, Alastair, Griffiths, Richard, Kreyman, Georg, Leverve, Xavier, Pichard, Claude

“…Summary Nutritional support in the intensive care setting represents a challenge but it is fortunate that its delivery and monitoring can be followed closely…”
Get full text

Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: a pilot randomised controlled clinical trial by Nalos, Marek, Leverve, Xavier, Huang, Stephen, Weisbrodt, Leonie, Parkin, Ray, Seppelt, Ian, Ting, Iris, Mclean, Anthony

“…Acute heart failure (AHF) is characterized by inadequate cardiac output (CO), congestive symptoms, poor peripheral perfusion and end-organ dysfunction…”
Get full text

Effects of a high-fat diet on energy metabolism and ROS production in rat liver by Vial, Guillaume, Dubouchaud, Hervé, Couturier, Karine, Cottet-Rousselle, Cécile, Taleux, Nellie, Athias, Anne, Galinier, Anne, Casteilla, Louis, Leverve, Xavier M

“…Background & Aims A high-fat diet affects liver metabolism, leading to steatosis, a complex disorder related to insulin resistance and mitochondrial…”
Get full text

A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study by Preiser, Jean-Charles, Devos, Philippe, Ruiz-Santana, Sergio, Mélot, Christian, Annane, Djillali, Groeneveld, Johan, Iapichino, Gaetano, Leverve, Xavier, Nitenberg, Gérard, Singer, Pierre, Wernerman, Jan, Joannidis, Michael, Stecher, Adela, Chioléro, René

“…Purpose An optimal target for glucose control in ICU patients remains unclear. This prospective randomized controlled trial compared the effects on ICU…”
Get full text

Mitochondrial function and substrate availability by Leverve, Xavier M

“…Carbohydrates and lipid oxidations support energy metabolism by distinct pathways exhibiting similarities and differences. Alterations of energy metabolism…”
Get full text

Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients by Ichai, Carole, Armando, Guy, Orban, Jean-Christophe, Berthier, Frederic, Rami, Laurent, Samat-Long, Corine, Grimaud, Dominique, Leverve, Xavier

“…Objectives Traumatic brain injury (TBI) is still a major cause of mortality and morbidity. Recent trials have failed to demonstrate a beneficial outcome from…”
Get full text

Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial by Ichai, Carole, Payen, Jean-François, Orban, Jean-Christophe, Quintard, Hervé, Roth, Hubert, Legrand, Robin, Francony, Gilles, Leverve, Xavier M.

“…Purpose Preventive treatments of traumatic intracranial hypertension are not yet established. We aimed to compare the efficiency of half-molar sodium lactate…”
Get full text

Opening of the Mitochondrial Permeability Transition Pore Induces Reactive Oxygen Species Production at the Level of the Respiratory Chain Complex I by Batandier, Cécile, Leverve, Xavier, Fontaine, Eric

“…We have investigated the consequences of permeability transition pore (PTP) opening on the rate of production of reactive oxygen species in isolated rat liver…”
Get full text

Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway by Morales, Ana I., Detaille, Dominique, Prieto, Marta, Puente, Angel, Briones, Elsa, Arévalo, Miguel, Leverve, Xavier, López-Novoa, José M., El-Mir, Mohamad-Yehia

“…The antidiabetic drug metformin can diminish apoptosis induced by oxidative stress in endothelial cells and prevent vascular dysfunction even in nondiabetic…”
Get full text

Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells by Sarre, Alexandre, Gabrielli, Jessica, Vial, Guillaume, Leverve, Xavier M., Assimacopoulos-Jeannet, Françoise

“…Excess reactive oxygen species (ROS) production is thought to play a key role in the loss of pancreatic β-cell number and/or function, in response to high…”
Get full text

Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D by Li, Bo, Chauvin, Christiane, De Paulis, Damien, De Oliveira, Frédéric, Gharib, Abdallah, Vial, Guillaume, Lablanche, Sandrine, Leverve, Xavier, Bernardi, Paolo, Ovize, Michel, Fontaine, Eric

“…Inhibition of the mitochondrial permeability transition pore (PTP) has proved to be an effective strategy for preventing oxidative stress-induced cell death,…”
Get full text

Potential Applications of Thyroid Hormone Derivatives in Obesity and Type 2 Diabetes: Focus on 3,5-Diiodothyronine (3,5-T2) in Psammomys obesus (Fat Sand Rat) Model by Bouazza, Asma, Favier, Roland, Fontaine, Eric, Leverve, Xavier, Koceir, Elhadj-Ahmed

“…3,5-Diiodothyronine (3,5-T2) has been shown to exert pleiotropic beneficial effects. In this study we investigated whether 3,5-T2 prevent several energy…”
Get full text

Neuroprotective Role of Antidiabetic Drug Metformin Against Apoptotic Cell Death in Primary Cortical Neurons by El-Mir, Mohamad-Yehia, Detaille, Dominique, R-Villanueva, Gloria, Delgado-Esteban, Maria, Guigas, Bruno, Attia, Stephane, Fontaine, Eric, Almeida, Angeles, Leverve, Xavier

“…Oxidative damage has been reported to be involved in the pathogenesis of diabetic neuropathy and neurodegenerative diseases. Recent evidence suggests that the…”
Get full text

Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process by DETAILLE, Dominique, GUIGAS, Bruno, CHAUVIN, Christiane, BATANDIER, Cécile, FONTAINE, Eric, WIERNSPERGER, Nicolas, LEVERVE, Xavier

“…Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process Dominique Detaille 1 , Bruno…”
Get full text

Nitric oxide increases oxidative phosphorylation efficiency by Clerc, Pascaline, Rigoulet, Michel, Leverve, Xavier, Fontaine, Eric

“…We have studied the effect of nitric oxide (NO) and potassium cyanide (KCN) on oxidative phosphorylation efficiency. Concentrations of NO or KCN that decrease…”
Get full text

Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I by El-Mir, M Y, Nogueira, V, Fontaine, E, Avéret, N, Rigoulet, M, Leverve, X

“…We report here a new mitochondrial regulation occurring only in intact cells. We have investigated the effects of dimethylbiguanide on isolated rat…”
Get full text

Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death by Devun, Flavien, Walter, Ludivine, Belliere, Julie, Cottet-Rousselle, Cécile, Leverve, Xavier, Fontaine, Eric

“…Prolonged opening of the mitochondrial permeability transition pore (PTP) leads to cell death. Various ubiquinone analogs have been shown to regulate PTP…”
Get full text

Early resuscitation of dengue shock syndrome in children with hyperosmolar sodium-lactate: a randomized single-blind clinical trial of efficacy and safety by Somasetia, Dadang H, Setiati, Tatty E, Sjahrodji, Azhali M, Idjradinata, Ponpon S, Setiabudi, Djatnika, Roth, Hubert, Ichai, Carole, Fontaine, Eric, Leverve, Xavier M

“…Dengue shock syndrome (DSS) fluid resuscitation by following the World Health Organization (WHO) guideline usually required large volumes of Ringer lactate…”
Get full text

Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients : A 2-year multicenter, prospective, randomized study by CANO, Noël J. M, FOUQUE, Denis, ROTH, Hubert, APARICIO, Michel, AZAR, Raymond, CANAUD, Bernard, CHAUVEAU, Philippe, COMBE, Christian, LAVILLE, Maurice, LEVERVE, Xavier M

“…Although intradialytic parenteral nutrition (IDPN) is a method used widely to combat protein-calorie malnutrition in hemodialysis patients, its effect on…”
Get full text