Search Results - "Lever, R."

Mast cell glycosaminoglycans by Mulloy, B., Lever, R., Page, C. P.

“…Mast cells contain granules packed with a mixture of proteins that are released on degranulation. The proteoglycan serglycin carries an array of…”
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Laminin receptor specific therapeutic gold nanoparticles (¹⁹⁸ AuNP-EGCg) show efficacy in treating prostate cancer by Shukla, Ravi, Chanda, Nripen, Zambre, Ajit, Upendran, Anandhi, Katti, Kavita, Kulkarni, Rajesh R., Nune, Satish Kumar, Casteel, Stan W., Smith, Charles Jeffrey, Vimal, Jatin, Boote, Evan, Robertson, J. David, Kan, Para, Engelbrecht, Hendrik, Watkinson, Lisa D., Carmack, Terry L., Lever, John R., Cutler, Cathy S., Caldwell, Charles, Kannan, Raghuraman, Katti, Kattesh V.

“…Systemic delivery of therapeutic agents to solid tumors is hindered by vascular and interstitial barriers. We hypothesized that prostate tumor specific…”
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Increased incidence of nitroimidazole-refractory giardiasis at the Hospital for Tropical Diseases, London: 2008–2013 by Nabarro, L.E.B., Lever, R.A., Armstrong, M., Chiodini, P.L.

“…Giardia intestinalis is the commonest gastrointestinal protozoal pathogen worldwide, and causes acute and chronic diarrhoea with malabsorption. First-line…”
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Efficacy and safety of low- versus high-dose glucocorticoid regimens for induction of remission of anti-neutrophil cytoplasm antibody-associated vasculitis: a systematic review and meta-analysis by Alchi, MB, Lever, R, Flossmann, O, Jayne, D

“…Glucocorticoids (GCs) remain a cornerstone of the initial management of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), but have several…”
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Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity by Chanda, Nripen, Kattumuri, Vijaya, Shukla, Ravi, Zambre, Ajit, Katti, Kavita, Upendran, Anandhi, Kulkarni, Rajesh R., Kan, Para, Fent, Genevieve M., Casteel, Stan W., Smith, C. Jeffrey, Boote, Evan, Robertson, J. David, Cutler, Cathy, Lever, John R., Katti, Kattesh V., Kannan, Raghuraman, Hawthorne, M. F.

“…Development of cancer receptor-specific gold nanoparticles will allow efficient targeting/optimum retention of engineered gold nanoparticles within tumors and…”
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Allosteric modulation of sigma receptors by BH3 mimetics ABT-737, ABT-263 (Navitoclax) and ABT-199 (Venetoclax) by Lever, John R., Fergason-Cantrell, Emily A.

“…[Display omitted] ABT-737, ABT-263 (Navitoclax) and ABT-199 (Venetoclax) are under intensive preclinical and clinical investigation as treatments for…”
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Exendin-4 reverts behavioural and neurochemical dysfunction in a pre-motor rodent model of Parkinson's disease with noradrenergic deficit by RAMPERSAUD, N, HARKAVYI, A, GIORDANO, G, LEVER, R, WHITTON, J, WHITTON, P. S

“…BACKGROUND AND PURPOSE Parkinson's disease (PD) is characterized by progressive dopaminergic cell loss; however, the noradrenergic system exhibits degeneration…”
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Liver Test Abnormalities in Patients with HIV Mono-Infection: Assessment with Simple Non-Invasive Fibrosis Markers by Lombardi, R, Lever, R, Smith, C, Marshall, N, Rodger, A, Bhagani, S, Tsochatzis, E

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Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ1 and σ2 receptors by Fan, Kuo-Hsien, Lever, John R., Lever, Susan Z.

“…A series of analogs, where the amine ring fused to the aromatic ring was varied in size (5–7) and the location of the nitrogen in this ring was modified, has…”
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Hexamidine salts – applications in skin health and personal care products by Parisi, N., Matts, P. J., Lever, R., Hadgraft, J., Lane, M. E.

“…Hexamidine (HEX) has been used as a preservative in topical preparations since the 1950s. A number of studies also indicate that the molecule plays a…”
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Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson’s disease with combined noradrenergic and serotonergic lesions by Rampersaud, N., Harkavyi, A., Giordano, G., Lever, R., Whitton, J., Whitton, P.S.

“…Research on Parkinson’s disease (PD) has mainly focused on the degeneration of the dopaminergic neurons of nigro-striatal pathway; however, post-mortem studies…”
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Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model by Rivera-Burgos, Dinelia, Sarkar, Ujjal, Lever, Amanda R, Avram, Michael J, Coppeta, Jonathan R, Wishnok, John S, Borenstein, Jeffrey T, Tannenbaum, Steven R

“…The emergence of microphysiologic epithelial lung models using human cells in a physiologically relevant microenvironment has the potential to be a powerful…”
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The sigma receptor agonist SA4503 both attenuates and enhances the effects of methamphetamine by Rodvelt, Kelli R, Oelrichs, Clark E, Blount, Lucas R, Fan, Kuo-Hsien, Lever, Susan Z, Lever, John R, Miller, Dennis K

“…Abstract Background Methamphetamine's behavioral effects have been attributed to its interaction with monoamine transporters; however, methamphetamine also has…”
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PET and SPECT imaging of the opioid system: receptors, radioligands and avenues for drug discovery and development by Lever, John R

“…As we celebrate the bicentennial of the isolation of morphine by Sertürner, opioids continue to dominate major sectors of the analgesic market worldwide. The…”
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The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro by Jones, N.A., Boswell-Smith, V., Lever, R., Page, Clive P.

“…Neutrophil-derived proteases such as neutrophil elastase (NE) and matrix metalloproteinase (MMP) are implicated in the pathogenesis of Chronic Obstructive…”
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SA 4503 attenuates cocaine-induced hyperactivity and enhances methamphetamine substitution for a cocaine discriminative stimulus by Rodvelt, Kelli R., Lever, Susan Z., Lever, John R., Blount, Lucas R., Fan, Kuo-Hsien, Miller, Dennis K.

“…Cocaine exhibits preferential (~ 15-fold) affinity for σ 1 over σ 2 sigma receptors, and previous research has shown an interaction of σ 1 receptor-selective…”
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Narrowband ultraviolet B (UVB) phototherapy in children by Jury, C. S., McHenry, P., Burden, A. D., Lever, R., Bilsland, D.

“…Summary Background.  While narrowband ultraviolet B (UVB) phototherapy is a well‐established treatment for a range of skin conditions in adults, there is…”
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Size‐fractionated heparins have differential effects on human neutrophil function in vitro by Lever, R, Lo, W T, Faraidoun, M, Amin, V, Brown, R A, Gallagher, J, Page, C P

“…Background and purpose: Heparin is known to possess a range of activities, other than effects on blood coagulation, many of which are anti‐inflammatory…”
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Retraction notice to exendin-4 reverses biochemical and behavioural deficits in a pre-motor rodent model of Parkinson’s disease with combined noradrenergic and serotonergic lesions [YNPEP 46 (2012) 183–193] by Rampersaud, N, Harkavyi, A, Giordano, G, Lever, R, Whitton, J, Whitton, P.S

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RETRACTED: Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson’s disease with combined noradrenergic and serotonergic lesions by Rampersaud, N, Harkavyi, A, Giordano, G, Lever, R, Whitton, J, Whitton, P.S

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal ( http://www.elsevier.com/locate/withdrawalpolicy ). This article has been…”
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