Search Results - "Lever, M"

Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells by Adedoyin, Oreoluwa, Boddu, Ravindra, Traylor, Amie, Lever, Jeremie M, Bolisetty, Subhashini, George, James F, Agarwal, Anupam

“…Ferroptosis is an iron-dependent form of regulated nonapoptotic cell death, which contributes to damage in models of acute kidney injury (AKI). Heme…”
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Renal Inflammation and Fibrosis: A Double-edged Sword by Black, Laurence M., Lever, Jeremie M., Agarwal, Anupam

“…Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote regeneration and repair. After renal injury, damaged tissue releases…”
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HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation by Gupta, Ravindra K., Abdul-Jawad, Sultan, McCoy, Laura E., Mok, Hoi Ping, Peppa, Dimitra, Salgado, Maria, Martinez-Picado, Javier, Nijhuis, Monique, Wensing, Annemarie M. J., Lee, Helen, Grant, Paul, Nastouli, Eleni, Lambert, Jonathan, Pace, Matthew, Salasc, Fanny, Monit, Christopher, Innes, Andrew J., Muir, Luke, Waters, Laura, Frater, John, Lever, Andrew M. L., Edwards, Simon G., Gabriel, Ian H., Olavarria, Eduardo

“…A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago 1 , 2 . The individual—who is known as the ‘Berlin patient’—underwent…”
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Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species by Zimmerman, Kurt A, Bentley, Melissa R, Lever, Jeremie M, Li, Zhang, Crossman, David K, Song, Cheng Jack, Liu, Shanrun, Crowley, Michael R, George, James F, Mrug, Michal, Yoder, Bradley K

“…Resident macrophages regulate homeostatic and disease processes in multiple tissues, including the kidney. Despite having well defined markers to identify…”
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Exploring deep microbial life in coal-bearing sediment down to ∼2.5 km below the ocean floor by Inagaki, F., Hinrichs, K.-U., Kubo, Y., Bowles, M. W., Heuer, V. B., Hong, W.-L., Hoshino, T., Ijiri, A., Imachi, H., Ito, M., Kaneko, M., Lever, M. A., Lin, Y.-S., Methé, B. A., Morita, S., Morono, Y., Tanikawa, W., Bihan, M., Bowden, S. A., Elvert, M., Glombitza, C., Gross, D., Harrington, G. J., Hori, T., Li, K., Limmer, D., Liu, C.-H., Murayama, M., Ohkouchi, N., Ono, S., Park, Y.-S., Phillips, S. C., Prieto-Mollar, X., Purkey, M., Riedinger, N., Sanada, Y., Sauvage, J., Snyder, G., Susilawati, R., Takano, Y., Tasumi, E., Terada, T., Tomaru, H., Trembath-Reichert, E., Wang, D. T., Yamada, Y.

“…Microbial life inhabits deeply buried marine sediments, but the extent of this vast ecosystem remains poorly constrained. Here we provide evidence for the…”
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Predictors of Long-Term Outcomes in Symptomatic Hypertrophic Obstructive Cardiomyopathy Patients Undergoing Surgical Relief of Left Ventricular Outflow Tract Obstruction by Desai, Milind Y, Bhonsale, Aditya, Smedira, Nicholas G, Naji, Peyman, Thamilarasan, Maran, Lytle, Bruce W, Lever, Harry M

“…BACKGROUND—We report the predictors of long-term outcomes of symptomatic hypertrophic cardiomyopathy patients undergoing surgical relief of left ventricular…”
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survival of filoviruses in liquids, on solid substrates and in a dynamic aerosol by Piercy, T.J, Smither, S.J, Steward, J.A, Eastaugh, L, Lever, M.S

“…Filoviruses are associated with high morbidity and lethality rates in humans, are capable of human-to-human transmission, via infected material such as blood,…”
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The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle by Meng, Bo, Lever, Andrew M L

“…Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT)…”
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Comparison of Experimental Middle East Respiratory Syndrome Coronavirus Infection Acquired by Three Individual Routes of Infection in the Common Marmoset by Nelson, Michelle, O'Brien, Lyn M, Davies, Carwyn, Keyser, Emma, Butcher, Wendy, Smither, Sophie J, Nunez, Alejandro, Salguero, F Javier, Lever, M Stephen

“…Two strains of Middle East respiratory syndrome coronavirus (MERS-CoV), England 1 and Erasmus Medical Centre/2012 (EMC/2012), were used to challenge common…”
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Updated Meta-Analysis of Septal Alcohol Ablation Versus Myectomy for Hypertrophic Cardiomyopathy by Agarwal, Shikhar, MD, MPH, Tuzcu, E. Murat, MD, Desai, Milind Y., MD, Smedira, Nicholas, MD, Lever, Harry M., MD, Lytle, Bruce W., MD, Kapadia, Samir R., MD

“…Objectives The purpose of this study was to perform a systematic review and meta-analysis of comparative studies to compare outcomes of septal ablation (SA)…”
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SUSCEPTIBILITY OF SYRIAN HAMSTERS TO NIPAH VIRUS INFECTION by Smither, S., Almond, N., Kempster, S., Williamson, E., Lever, M.

“…Nipah virus is an emerging zoonotic pathogen that causes disease outbreaks in South-East Asia with high case fatality rates. It is considered to be a public…”
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Mononuclear phagocyte subpopulations in the mouse kidney by George, James F, Lever, Jeremie M, Agarwal, Anupam

“…Mononuclear phagocytes are the most common cells in the kidney associated with immunity and inflammation. Although the presence of these cells in the kidney…”
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HIV Gag polyprotein: processing and early viral particle assembly by Bell, Neil M, Lever, Andrew M.L

“…Over the past several decades, extensive research into the Gag polyprotein, the main structural protein of HIV-1 and all other retroviruses, has changed the…”
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RNA Structure-A Neglected Puppet Master for the Evolution of Virus and Host Immunity by Smyth, Redmond P, Negroni, Matteo, Lever, Andrew M, Mak, Johnson, Kenyon, Julia C

“…The central dogma of molecular biology describes the flow of genetic information from DNA to protein via an RNA intermediate. For many years, RNA has been…”
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Low Operative Mortality Achieved With Surgical Septal Myectomy by Maron, Barry J., MD, Dearani, Joseph A., MD, Ommen, Steve R., MD, Maron, Martin S., MD, Schaff, Hartzell V., MD, Nishimura, Rick A., MD, Ralph-Edwards, Anthony, MD, Rakowski, Harry, MD, Sherrid, Mark V., MD, Swistel, Daniel G., MD, Balaram, Sandhya, MD, Rastegar, Hassan, MD, Rowin, Ethan J., MD, Smedira, Nicholas G., MD, Lytle, Bruce W., MD, Desai, Milind Y., MD, Lever, Harry M., MD

“…Contemporary mortality data for myectomy are well known to experts in dedicated HCM centers but may not have penetrated sufficiently into the practicing…”
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Experimental pathways towards developing a rotavirus reverse genetics system: synthetic full length rotavirus ssRNAs are neither infectious nor translated in permissive cells by Richards, James E, Desselberger, Ulrich, Lever, Andrew M

“…At present the ability to create rationally engineered mutant rotaviruses is limited because of the lack of a tractable helper virus-free reverse genetics…”
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DDX5 potentiates HIV-1 transcription as a co-factor of Tat by Sithole, Nyaradzai, Williams, Claire A, Abbink, Truus E M, Lever, Andrew M L

“…HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is…”
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A scale-free analysis of the HIV-1 genome demonstrates multiple conserved regions of structural and functional importance by Skittrall, Jordan P, Ingemarsdotter, Carin K, Gog, Julia R, Lever, Andrew M L

“…HIV-1 replicates via a low-fidelity polymerase with a high mutation rate; strong conservation of individual nucleotides is highly indicative of the presence of…”
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Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy by Hutt, Erika, Mentias, Amgad, Alashi, Alaa, Wadhwa, Raoul, Fava, Agostina, Lever, Harry M., Thamilarasan, Maran, Popovic, Zoran B., Smedira, Nicholas G., Desai, Milind Y.

“…We sought to determine the incremental prognostic value of age-sex adjusted N-terminal prohormone brain natriuretic peptide (NT-pro BNP) ratio in obstructive…”
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Current Effectiveness and Risks of Isolated Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy by Smedira, Nicholas G., MD, Lytle, Bruce W., MD, Lever, Harry M., MD, Rajeswaran, Jeevanantham, MS, Krishnaswamy, Gita, MS, Kaple, Ryan K., BS, Dolney, Diana O.W., MSN, RN, Blackstone, Eugene H., MD

“…Background Septal myectomy is the gold-standard therapy for hypertrophic obstructive cardiomyopathy (HOCM). However, it is being challenged by a less-invasive…”
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