Search Results - "Lever, Isobel J"

Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury by Lever, Isobel J, Robinson, Michelle, Cibelli, Mario, Paule, Cleoper, Santha, Peter, Yee, Louis, Hunt, Stephen P, Cravatt, Benjamin F, Elphick, Maurice R, Nagy, Istvan, Rice, Andrew S. C

“…Fatty acid amide hydrolase (FAAH) is a degradative enzyme for a group of endogenous signaling lipids that includes anandamide (AEA). AEA acts as an…”
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Brain-Derived Neurotrophic Factor Is Released in the Dorsal Horn by Distinctive Patterns of Afferent Fiber Stimulation by Lever, Isobel J, Bradbury, Elizabeth J, Cunningham, Joanna R, Adelson, David W, Jones, Martyn G, McMahon, Stephen B, Marvizon, Juan Carlos G, Malcangio, Marzia

“…Brain-derived neurotrophic factor (BDNF) is synthesized by small neuron cell bodies in the dorsal root ganglia (DRG) and is anterogradely transported to…”
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A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones by Malcangio, Marzia, Getting, Stephen, Grist, John, Cunningham, Joanna R., Bradbury, Elizabeth J., Issa, Peter Charbel, Lever, Isobel J., Pezet, Sophie, Perretti, Mauro

“…Small‐diameter sensory neurones found in the rat dorsal root ganglia (DRG) include cells sensitive to glial cell line‐derived neurotrophic factor (GDNF), which…”
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Noxious Stimulation Induces Trk Receptor and Downstream ERK Phosphorylation in Spinal Dorsal Horn by Pezet, Sophie, Malcangio, Marzia, Lever, Isobel J., Perkinton, Michael S., Thompson, Stephen W.N., Williams, Robert J., McMahon, Stephen B.

“…Several lines of evidence suggest that the brain-derived neurotrophic factor (BDNF) acts as central pain neuromodulator.We examined the ability of different…”
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The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn by Lever, Isobel J, Pezet, Sophie, McMahon, Stephen B, Malcangio, Marzia

“…The stimulation of C-fiber sensory neurons is known to induce activation of the ERK MAP kinase signaling pathway in the spinal cord dorsal horn. In this study…”
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BDNF Modulates Sensory Neuron Synaptic Activity by a Facilitation of GABA Transmission in the Dorsal Horn by Pezet, Sophie, Cunningham, Joanna, Patel, Jaykumar, Grist, John, Gavazzi, Isabella, Lever, Isobel J., Malcangio, Marzia

“…Topical application of brain-derived neurotrophic factor (BDNF) to the adult rat isolated dorsal horn with dorsal root attached preparation inhibited the…”
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Glial cell line-derived neurotrophic factor increases calcitonin gene-related peptide immunoreactivity in sensory and motoneurons in vivo by Ramer, Matt S., Bradbury, Elizabeth J., Michael, Gregory J., Lever, Isobel J., McMahon, Stephen B.

“…Calcitonin gene‐related peptide (CGRP) is expressed at high levels in roughly 50% of spinal sensory neurons and plays a role in peripheral vasodilation as well…”
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Role of interleukin-1β in postoperative cognitive dysfunction by Cibelli, Mario, Fidalgo, Antonio Rei, Terrando, Niccolò, Ma, Daqing, Monaco, Claudia, Feldmann, Marc, Takata, Masao, Lever, Isobel J., Nanchahal, Jagdeep, Fanselow, Michael S., Maze, Mervyn

“…Objective: Although postoperative cognitive dysfunction (POCD) often complicates recovery from major surgery, the pathogenic mechanisms remain unknown. We…”
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Basal and activity-induced release of substance P from primary afferent fibres in NK1 receptor knockout mice: evidence for negative feedback by LEVER, Isobel J, GRANT, Andrew D, PEZET, Sophie, GERARD, Norma P, BRAIN, Susan D, MALCANGIO, Marzia

“…The concept that NK1 receptors are located pre-junctionally on substance P (SP)-containing nerves, acting as autoreceptors to inhibit SP release, has been…”
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Intrathecally delivered glial cell line‐derived neurotrophic factor produces electrically evoked release of somatostatin in the dorsal horn of the spinal cord by Issa, Peter Charbel, Lever, Isobel J., Michael, Gregory J., Bradbury, Elizabeth J., Malcangio, Marzia

“…Glial cell line‐derived neurotrophic factor (GDNF) is a trophic factor with an established role in sensory neuron development. More recently it has also been…”
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Role of interleukin-1 Delta b in postoperative cognitive dysfunction by Cibelli, Mario, Fidalgo, Antonio Rei, Terrando, Niccolo, Ma, Daqing, Monaco, Claudia, Feldmann, Marc, Takata, Masao, Lever, Isobel J, Nanchahal, Jagdeep, Fanselow, Michael S, Maze, Mervyn

“…Objective: Although postoperative cognitive dysfunction (POCD) often complicates recovery from major surgery, the pathogenic mechanisms remain unknown. We…”
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Role of interleukin-1[beta] in postoperative cognitive dysfunction by Cibelli, Mario, Fidalgo, Antonio Rei, Terrando, Niccolò, Ma, Daqing, Monaco, Claudia, Feldmann, Marc, Takata, Masao, Lever, Isobel J, Nanchahal, Jagdeep, Fanselow, Michael S, Maze, Mervyn

“…Objective: Although postoperative cognitive dysfunction (POCD) often complicates recovery from major surgery, the pathogenic mechanisms remain unknown. We…”
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Role of interleukin-1beta in postoperative cognitive dysfunction by Cibelli, Mario, Fidalgo, Antonio Rei, Terrando, Niccolò, Ma, Daqing, Monaco, Claudia, Feldmann, Marc, Takata, Masao, Lever, Isobel J, Nanchahal, Jagdeep, Fanselow, Michael S, Maze, Mervyn

“…Although postoperative cognitive dysfunction (POCD) often complicates recovery from major surgery, the pathogenic mechanisms remain unknown. We explored…”
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Basal and activity-induced release of substance P from primary afferent fibres in NK 1 receptor knockout mice: evidence for negative feedback by Lever, Isobel J, Grant, Andrew D, Pezet, Sophie, Gerard, Norma P, Brain, Susan D, Malcangio, Marzia

“…The concept that NK 1 receptors are located pre-junctionally on substance P (SP)-containing nerves, acting as autoreceptors to inhibit SP release, has been…”
Get full text