The Effect of Preoperative Chemoradiotherapy on Lymph Node Harvest After Total Mesorectal Excision for Rectal Cancer

PURPOSE:This study was designed to evaluate whether preoperative chemoradiotherapy reduces the number of lymph nodes harvested after total mesorectal excision of rectal cancer. METHODS:From January 1995 to December 2007, 168 consecutive patients with rectal cancer underwent total mesorectal excision...

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Bibliographic Details
Published in:	Diseases of the colon & rectum Vol. 52; no. 8; pp. 1470 - 1474
Main Authors:	Taflampas, Panagiotis, Christodoulakis, Manousos, Gourtsoyianni, Sofia, Leventi, Katerina, Melissas, John, Tsiftsis, Dimitrios D
Format:	Journal Article
Language:	English
Published:	Hagerstown, MDc The ASCRS 01-08-2009 Lippincott Williams & Wilkins
Subjects:	Adenocarcinoma - secondary Adenocarcinoma - therapy Aged Antineoplastic Agents - therapeutic use Biological and medical sciences Colectomy - methods Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Humans Lymph Node Excision - methods Lymph Nodes - pathology Lymphatic Metastasis Male Medical sciences Neoplasm Staging - methods Preoperative Care - methods Prognosis Radiotherapy, Adjuvant Rectal Neoplasms - pathology Rectal Neoplasms - therapy Retrospective Studies Stomach, duodenum, intestine, rectum, anus Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tissue and Organ Harvesting - methods Tumors Lymph node retrieval Proctectomy Rectal disease Lymph node Rectal cancer Preoperative chemoradiotherapy Malignant tumor Rectum cancer Radiotherapy Chemoradiotherapy Lymph nodes Preoperative radiotherapy Treatment Gastroenterology Digestive diseases Intestinal disease Preoperative Anorectal disease Cancer
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Summary:	PURPOSE:This study was designed to evaluate whether preoperative chemoradiotherapy reduces the number of lymph nodes harvested after total mesorectal excision of rectal cancer. METHODS:From January 1995 to December 2007, 168 consecutive patients with rectal cancer underwent total mesorectal excision in the Department of Surgical Oncology at the University of Crete. The patients were divided into three groups (Group A, no chemoradiotherapy; Group B, short course of chemoradiotherapy; Group C, long course of chemoradiotherapy). The primary end points were the number of lymph nodes examined and the percentage of patients with fewer than 12 lymph nodes removed. RESULTS:The overall number of lymph nodes retrieved was not significantly reduced by the use of preoperative chemoradiotherapy. The percentage of patients with fewer than 12 lymph nodes examined, however, was significantly higher in Group C. The leakage rate and the duration of hospital stay were not affected. The rate of wound infections was higher in Group C. CONCLUSION:Preoperative chemoradiotherapy did not significantly decrease the overall number of lymph nodes retrieved but did increase the percentage of patients with fewer than 12 lymph nodes examined.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0012-3706 1530-0358
DOI:	10.1007/DCR.0b013e3181a0e6ac