Search Results - "Levasseur, Peter R"

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer by Michaelis, Katherine A., Norgard, Mason A., Zhu, Xinxia, Levasseur, Peter R., Sivagnanam, Shamilene, Liudahl, Shannon M., Burfeind, Kevin G., Olson, Brennan, Pelz, Katherine R., Angeles Ramos, Diana M., Maurer, H. Carlo, Olive, Kenneth P., Coussens, Lisa M., Morgan, Terry K., Marks, Daniel L.

“…A priority in cancer research is to innovate therapies that are not only effective against tumor progression but also address comorbidities such as cachexia…”
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Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia by Olson, Brennan, Zhu, Xinxia, Norgard, Mason A., Levasseur, Peter R., Butler, John T., Buenafe, Abigail, Burfeind, Kevin G., Michaelis, Katherine A., Pelz, Katherine R., Mendez, Heike, Edwards, Jared, Krasnow, Stephanie M., Grossberg, Aaron J., Marks, Daniel L.

“…Lipocalin 2 (LCN2) was recently identified as an endogenous ligand of the type 4 melanocortin receptor (MC4R), a critical regulator of appetite. However, it…”
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Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle by Braun, Theodore P, Szumowski, Marek, Levasseur, Peter R, Grossberg, Aaron J, Zhu, XinXia, Agarwal, Anupriya, Marks, Daniel L

“…Cancer cachexia is a syndrome of weight loss that results from the selective depletion of skeletal muscle mass and contributes significantly to cancer…”
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Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment by Olson, Brennan, Zhu, Xinxia, Norgard, Mason A., Diba, Parham, Levasseur, Peter R., Buenafe, Abby C., Huisman, Christian, Burfeind, Kevin G., Michaelis, Katherine A., Kong, Garth, Braun, Theodore, Marks, Daniel L.

“…•LCN2 is robustly upregulated in the central nervous system during acute and chronic inflammation.•Chronic, but not acute, central LCN2 treatment alters…”
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Establishment and characterization of a novel murine model of pancreatic cancer cachexia by Michaelis, Katherine A., Zhu, Xinxia, Burfeind, Kevin G., Krasnow, Stephanie M., Levasseur, Peter R., Morgan, Terry K., Marks, Daniel L.

“…Background Cachexia is a complex metabolic and behavioural syndrome lacking effective therapies. Pancreatic ductal adenocarcinoma (PDAC) is one of the most…”
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Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis by Braun, Theodore P, Zhu, Xinxia, Szumowski, Marek, Scott, Gregory D, Grossberg, Aaron J, Levasseur, Peter R, Graham, Kathryn, Khan, Sheehan, Damaraju, Sambasivarao, Colmers, William F, Baracos, Vickie E, Marks, Daniel L

“…Skeletal muscle catabolism is a co-morbidity of many chronic diseases and is the result of systemic inflammation. Although direct inflammatory cytokine action…”
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TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia by Burfeind, Kevin G., Zhu, Xinxia, Levasseur, Peter R., Michaelis, Katherine A., Norgard, Mason A., Marks, Daniel L.

“…•TRIFKO mice have attenuated sickness behavior after LPS exposure.•TRIF is important for neutrophil recruitment and microglia activation after central LPS…”
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Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer by Burfeind, Kevin G, Zhu, Xinxia, Norgard, Mason A, Levasseur, Peter R, Huisman, Christian, Buenafe, Abigail C, Olson, Brennan, Michaelis, Katherine A, Torres, Eileen Rs, Jeng, Sophia, McWeeney, Shannon, Raber, Jacob, Marks, Daniel L

“…Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of…”
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Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance by Michaelis, Katherine A., Norgard, Mason A., Levasseur, Peter R., Olson, Brennan, Burfeind, Kevin G., Buenafe, Abigail C., Zhu, Xinxia, Jeng, Sophia, McWeeney, Shannon K., Marks, Daniel L.

“…•Within the CNS, toll-like receptor 7 (Tlr7) is most abundantly expressed in microglia.•Microglia produce abundant pro-inflammatory signals upon initial Tlr7…”
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Inflammation-induced lethargy is mediated by suppression of orexin neuron activity by Grossberg, Aaron J, Zhu, XinXia, Leinninger, Gina M, Levasseur, Peter R, Braun, Theodore P, Myers, Jr, Martin G, Marks, Daniel L

“…In response to illness, animals subvert normal homeostasis and divert their energy utilization to fight infection. An important and unexplored feature of this…”
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Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells by Krasnow, Stephanie M, Knoll, J Gabriel, Verghese, Santhosh Chakkaramakkil, Levasseur, Peter R, Marks, Daniel L

“…During acute infections and chronic illnesses, the pro-inflammatory cytokine interleukin-1β (IL-1β) acts within the brain to elicit metabolic derangements and…”
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Cancer‐ and endotoxin‐induced cachexia require intact glucocorticoid signaling in skeletal muscle by Braun, Theodore P., Grossberg, Aaron J., Krasnow, Stephanie M., Levasseur, Peter R., Szumowski, Marek, Zhu, Xin Xia, Maxson, Julia E., Knoll, J. Gabriel, Barnes, Anthony P., Marks, Daniel L.

“…Cachexia is a wasting condition defined by skeletal muscle atrophy in the setting of systemic inflammation. To explore the site at which inflammatory mediators…”
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Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia by Olson, Brennan, Norgard, Mason A., Levasseur, Peter R., Zhu, Xinxia, Marks, Daniel L.

“…Background Cancer cachexia is a metabolic disorder characterized by the progressive loss of fat and lean mass that results in significant wasting, ultimately…”
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GDF15 and LCN2 for early detection and prognosis of pancreatic cancer by Zhu, Xinxia, Olson, Brennan, Keith, Dove, Norgard, Mason A, Levasseur, Peter R, Diba, Parham, Protzek, Sara, Li, Ju, Li, Xiaolin, Korzun, Tetiana, Sattler, Ariana L, Buenafe, Abigail C, Grossberg, Aaron J, Marks, Daniel L

“…•Circulating GDF15 and LCN2 are higher in patients and mice with PDAC.•Elevated GDF15 and LCN2 are correlated to PDAC onset, progression and poor…”
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Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing by Huisman, Christian, Norgard, Mason A., Levasseur, Peter R., Krasnow, Stephanie M., van der Wijst, Monique G.P., Olson, Brennan, Marks, Daniel L.

“…Cancer cachexia is a devastating chronic condition characterized by involuntary weight loss, muscle wasting, abnormal fat metabolism, anorexia, and fatigue…”
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Ghrelin Treatment of Chronic Kidney Disease: Improvements in Lean Body Mass and Cytokine Profile by DeBoer, Mark D, Zhu, Xinxia, Levasseur, Peter R, Inui, Akio, Hu, Zhaoyong, Han, Guofeng, Mitch, William E, Taylor, John E, Halem, Heather A, Dong, Jesse Z, Datta, Rakesh, Culler, Michael D, Marks, Daniel L

“…Chronic kidney disease (CKD) is associated with an increase in inflammatory cytokines and can result in cachexia with loss of muscle and fat stores. We…”
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Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling by Kram, David E, Krasnow, Stephanie M, Levasseur, Peter R, Zhu, Xinxia, Stork, Linda C, Marks, Daniel L

“…Steroid-induced sleep disturbance is a common and highly distressing morbidity for children receiving steroid chemotherapy for the treatment of pediatric acute…”
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Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis by Begriche, Karima, Levasseur, Peter R., Zhang, Jingying, Rossi, Jari, Skorupa, Danielle, Solt, Laura A., Young, Brandon, Burris, Thomas P., Marks, Daniel L., Mynatt, Randall L., Butler, Andrew A.

“…The melanocortin-3 receptor (MC3R) gene is pleiotropic, influencing body composition, natriuresis, immune function, and entrainment of circadian rhythms to…”
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Publisher Correction: The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer by Michaelis, Katherine A., Norgard, Mason A., Zhu, Xinxia, Levasseur, Peter R., Sivagnanam, Shamilene, Liudahl, Shannon M., Burfeind, Kevin G., Olson, Brennan, Pelz, Katherine R., Ramos, Diana M. Angeles, Maurer, H. Carlo, Olive, Kenneth P., Coussens, Lisa M., Morgan, Terry K., Marks, Daniel L.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Maternal high-fat diet and obesity compromise fetal hematopoiesis by Kamimae-Lanning, Ashley N, Krasnow, Stephanie M, Goloviznina, Natalya A, Zhu, Xinxia, Roth-Carter, Quinn R, Levasseur, Peter R, Jeng, Sophia, McWeeney, Shannon K, Kurre, Peter, Marks, Daniel L

“…Abstract Objective Recent evidence indicates that the adult hematopoietic system is susceptible to diet-induced lineage skewing. It is not known whether the…”
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