Search Results - "Levasseur, Peter"

Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle by Braun, Theodore P, Szumowski, Marek, Levasseur, Peter R, Grossberg, Aaron J, Zhu, XinXia, Agarwal, Anupriya, Marks, Daniel L

“…Cancer cachexia is a syndrome of weight loss that results from the selective depletion of skeletal muscle mass and contributes significantly to cancer…”
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The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer by Michaelis, Katherine A., Norgard, Mason A., Zhu, Xinxia, Levasseur, Peter R., Sivagnanam, Shamilene, Liudahl, Shannon M., Burfeind, Kevin G., Olson, Brennan, Pelz, Katherine R., Angeles Ramos, Diana M., Maurer, H. Carlo, Olive, Kenneth P., Coussens, Lisa M., Morgan, Terry K., Marks, Daniel L.

“…A priority in cancer research is to innovate therapies that are not only effective against tumor progression but also address comorbidities such as cachexia…”
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Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia by Olson, Brennan, Zhu, Xinxia, Norgard, Mason A., Levasseur, Peter R., Butler, John T., Buenafe, Abigail, Burfeind, Kevin G., Michaelis, Katherine A., Pelz, Katherine R., Mendez, Heike, Edwards, Jared, Krasnow, Stephanie M., Grossberg, Aaron J., Marks, Daniel L.

“…Lipocalin 2 (LCN2) was recently identified as an endogenous ligand of the type 4 melanocortin receptor (MC4R), a critical regulator of appetite. However, it…”
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Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment by Olson, Brennan, Zhu, Xinxia, Norgard, Mason A., Diba, Parham, Levasseur, Peter R., Buenafe, Abby C., Huisman, Christian, Burfeind, Kevin G., Michaelis, Katherine A., Kong, Garth, Braun, Theodore, Marks, Daniel L.

“…•LCN2 is robustly upregulated in the central nervous system during acute and chronic inflammation.•Chronic, but not acute, central LCN2 treatment alters…”
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Establishment and characterization of a novel murine model of pancreatic cancer cachexia by Michaelis, Katherine A., Zhu, Xinxia, Burfeind, Kevin G., Krasnow, Stephanie M., Levasseur, Peter R., Morgan, Terry K., Marks, Daniel L.

“…Background Cachexia is a complex metabolic and behavioural syndrome lacking effective therapies. Pancreatic ductal adenocarcinoma (PDAC) is one of the most…”
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Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis by Braun, Theodore P, Zhu, Xinxia, Szumowski, Marek, Scott, Gregory D, Grossberg, Aaron J, Levasseur, Peter R, Graham, Kathryn, Khan, Sheehan, Damaraju, Sambasivarao, Colmers, William F, Baracos, Vickie E, Marks, Daniel L

“…Skeletal muscle catabolism is a co-morbidity of many chronic diseases and is the result of systemic inflammation. Although direct inflammatory cytokine action…”
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TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia by Burfeind, Kevin G., Zhu, Xinxia, Levasseur, Peter R., Michaelis, Katherine A., Norgard, Mason A., Marks, Daniel L.

“…•TRIFKO mice have attenuated sickness behavior after LPS exposure.•TRIF is important for neutrophil recruitment and microglia activation after central LPS…”
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Microglia in the hypothalamus respond to tumor‐derived factors and are protective against cachexia during pancreatic cancer by Burfeind, Kevin G., Zhu, Xinxia, Norgard, Mason A., Levasseur, Peter R., Huisman, Christian, Michaelis, Katherine A., Olson, Brennan, Marks, Daniel L.

“…Microglia in the mediobasal hypothalamus (MBH) respond to inflammatory stimuli and metabolic perturbations to mediate body composition. This concept is well…”
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Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer by Burfeind, Kevin G, Zhu, Xinxia, Norgard, Mason A, Levasseur, Peter R, Huisman, Christian, Buenafe, Abigail C, Olson, Brennan, Michaelis, Katherine A, Torres, Eileen Rs, Jeng, Sophia, McWeeney, Shannon, Raber, Jacob, Marks, Daniel L

“…Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of…”
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Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance by Michaelis, Katherine A., Norgard, Mason A., Levasseur, Peter R., Olson, Brennan, Burfeind, Kevin G., Buenafe, Abigail C., Zhu, Xinxia, Jeng, Sophia, McWeeney, Shannon K., Marks, Daniel L.

“…•Within the CNS, toll-like receptor 7 (Tlr7) is most abundantly expressed in microglia.•Microglia produce abundant pro-inflammatory signals upon initial Tlr7…”
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Lipid Nanoparticles Elicit Reactogenicity and Sickness Behavior in Mice Via Toll-Like Receptor 4 and Myeloid Differentiation Protein 88 Axis by Korzun, Tetiana, Moses, Abraham S., Jozic, Antony, Grigoriev, Vladislav, Newton, Samuel, Kim, Jeonghwan, Diba, Parham, Sattler, Ariana, Levasseur, Peter R., Le, Ngoc, Singh, Prem, Sharma, Kongbrailatpam Shitaljit, Goo, Yoon Tae, Mamnoon, Babak, Raitmayr, Constanze, Mesquita Souza, Ana Paula, Taratula, Olena R., Sahay, Gaurav, Taratula, Oleh, Marks, Daniel L.

“…mRNA therapeutics encapsulated in lipid nanoparticles (LNPs) offer promising avenues for treating various diseases. While mRNA vaccines anticipate…”
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Inflammation-induced lethargy is mediated by suppression of orexin neuron activity by Grossberg, Aaron J, Zhu, XinXia, Leinninger, Gina M, Levasseur, Peter R, Braun, Theodore P, Myers, Jr, Martin G, Marks, Daniel L

“…In response to illness, animals subvert normal homeostasis and divert their energy utilization to fight infection. An important and unexplored feature of this…”
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Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells by Krasnow, Stephanie M, Knoll, J Gabriel, Verghese, Santhosh Chakkaramakkil, Levasseur, Peter R, Marks, Daniel L

“…During acute infections and chronic illnesses, the pro-inflammatory cytokine interleukin-1β (IL-1β) acts within the brain to elicit metabolic derangements and…”
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Targeting Metastasis in Head and Neck Squamous Cell Carcinoma Using Follistatin mRNA Lipid Nanoparticles by Grigoriev, Vladislav, Korzun, Tetiana, Moses, Abraham S., Jozic, Antony, Zhu, Xinxia, Kim, Jeonghwan, Newton, Samuel, Eygeris, Yulia, Diba, Parham, Sattler, Ariana L., Levasseur, Peter R., Olson, Brennan, Le, Ngoc, Singh, Prem, Sharma, Kongbrailatpam Shitaljit, Goo, Yoon Tae, Mamnoon, Babak, Raitmayr, Constanze, Mesquita Souza, Ana Paula, Taratula, Olena R., Sahay, Gaurav, Marks, Daniel L., Taratula, Oleh

“…Metastatic progression significantly reduces survival rates and complicates treatment strategies in various cancers. Our study introduces an mRNA therapy for…”
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Targeted Nanocarriers for Systemic Delivery of IRAK4 Inhibitors to Inflamed Tissues by Park, Youngrong, Korzun, Tetiana, Moses, Abraham S., Singh, Prem, Levasseur, Peter R., Demessie, Ananiya A., Sharma, Kongbrailatpam Shitaljit, Morgan, Terry, Raitmayr, Constanze J., Avila, Uriel, Sabei, Fahad Y., Taratula, Olena R., Marks, Daniel L., Taratula, Oleh

“…Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a…”
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Cancer‐ and endotoxin‐induced cachexia require intact glucocorticoid signaling in skeletal muscle by Braun, Theodore P., Grossberg, Aaron J., Krasnow, Stephanie M., Levasseur, Peter R., Szumowski, Marek, Zhu, Xin Xia, Maxson, Julia E., Knoll, J. Gabriel, Barnes, Anthony P., Marks, Daniel L.

“…Cachexia is a wasting condition defined by skeletal muscle atrophy in the setting of systemic inflammation. To explore the site at which inflammatory mediators…”
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Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia by Olson, Brennan, Norgard, Mason A., Levasseur, Peter R., Zhu, Xinxia, Marks, Daniel L.

“…Background Cancer cachexia is a metabolic disorder characterized by the progressive loss of fat and lean mass that results in significant wasting, ultimately…”
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Tumor-derived cyclooxygenase-2 fuels hypothalamic inflammation by Li, Xiaolin, Zhu, Xinxia, Diba, Parham, Shi, Xuan, Vrieling, Frank, Jansen, Fleur A.C., Balvers, Michiel G.J., de Bus, Ian, Levasseur, Peter R., Sattler, Ariana, Arneson-Wissink, Paige C., Poland, Mieke, Witkamp, Renger F., van Norren, Klaske, Marks, Daniel L.

“…•Tumor-derived Prostaglandin E2 (via COX-2) and host gut-originated LPS synergistically amplify hypothalamic inflammation in vitro and in vivo.•Prostaglandin…”
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Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling by Kram, David E, Krasnow, Stephanie M, Levasseur, Peter R, Zhu, Xinxia, Stork, Linda C, Marks, Daniel L

“…Steroid-induced sleep disturbance is a common and highly distressing morbidity for children receiving steroid chemotherapy for the treatment of pediatric acute…”
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Nanoparticle‐Based Follistatin Messenger RNA Therapy for Reprogramming Metastatic Ovarian Cancer and Ameliorating Cancer‐Associated Cachexia by Korzun, Tetiana, Moses, Abraham S., Kim, Jeonghwan, Patel, Siddharth, Schumann, Canan, Levasseur, Peter R., Diba, Parham, Olson, Brennan, Rebola, Katia Graziella De Oliveira, Norgard, Mason, Park, Youngrong, Demessie, Ananiya A., Eygeris, Yulia, Grigoriev, Vladislav, Sundaram, Subisha, Pejovic, Tanja, Brody, Jonathan R., Taratula, Olena R., Zhu, Xinxia, Sahay, Gaurav, Marks, Daniel L., Taratula, Oleh

“…This study presents the first messenger RNA (mRNA) therapy for metastatic ovarian cancer and cachexia‐induced muscle wasting based on lipid nanoparticles that…”
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