Search Results - "Levanon, Erez"

A-to-I RNA editing — immune protector and transcriptome diversifier by Eisenberg, Eli, Levanon, Erez Y.

“…Modifications of RNA affect its function and stability. RNA editing is unique among these modifications because it not only alters the cellular fate of RNA…”
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Human housekeeping genes, revisited by Eisenberg, Eli, Levanon, Erez Y

“…Highlights • Most human genes are expressed in all tissues to some extent • Housekeeping genes may be defined by constant level of expression across tissues •…”
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Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity by Roth, Shalom Hillel, Levanon, Erez Y., Eisenberg, Eli

“…Adenosine-to-inosine (A-to-I) RNA editing by the adenosine deaminase that acts on RNA (ADAR) enzymes is a common RNA modification, preventing false activation…”
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Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals by Ivanov, Andranik, Memczak, Sebastian, Wyler, Emanuel, Torti, Francesca, Porath, Hagit T., Orejuela, Marta R., Piechotta, Michael, Levanon, Erez Y., Landthaler, Markus, Dieterich, Christoph, Rajewsky, Nikolaus

“…Circular RNAs (circRNAs) are a large class of animal RNAs. To investigate possible circRNA functions, it is important to understand circRNA biogenesis. Besides…”
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Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors by Paz-Yaacov, Nurit, Bazak, Lily, Buchumenski, Ilana, Porath, Hagit T., Danan-Gotthold, Miri, Knisbacher, Binyamin A., Eisenberg, Eli, Levanon, Erez Y.

“…Genomic mutations in key genes are known to drive tumorigenesis and have been the focus of much attention in recent years. However, genetic content also may…”
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The cell line A-to-I RNA editing catalogue by Schaffer, Amos A, Kopel, Eli, Hendel, Ayal, Picardi, Ernesto, Levanon, Erez Y, Eisenberg, Eli

“…Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation…”
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A genome-wide map of hyper-edited RNA reveals numerous new sites by Porath, Hagit T., Carmi, Shai, Levanon, Erez Y.

“…Adenosine-to-inosine editing is one of the most frequent post-transcriptional modifications, manifested as A-to-G mismatches when comparing RNA sequences with…”
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Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities by Schneider, Nina, Sundaresan, Yogapriya, Gopalakrishnan, Prakadeeswari, Beryozkin, Avigail, Hanany, Mor, Levanon, Erez Y., Banin, Eyal, Ben-Aroya, Shay, Sharon, Dror

“…Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual impairment phenotypes caused by pathogenic variants in at least 277…”
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Trade-off between Transcriptome Plasticity and Genome Evolution in Cephalopods by Liscovitch-Brauer, Noa, Alon, Shahar, Porath, Hagit T., Elstein, Boaz, Unger, Ron, Ziv, Tamar, Admon, Arie, Levanon, Erez Y., Rosenthal, Joshua J.C., Eisenberg, Eli

“…RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among…”
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In search of critical dsRNA targets of ADAR1 by Levanon, Erez Y., Cohen-Fultheim, Roni, Eisenberg, Eli

“…Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing by ADAR in suppressing innate immune interferon responses triggered by…”
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Computational approaches for detection and quantification of A-to-I RNA-editing by Pinto, Yishay, Levanon, Erez Y.

“…•Review of methods to detect and quantify RNA editing utilizing sequencing data.•Having both RNA- and matched DNA-seq is the optimal set up for editing…”
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Human cancer tissues exhibit reduced A-to-I editing of miRNAs coupled with elevated editing of their targets by Pinto, Yishay, Buchumenski, Ilana, Levanon, Erez Y, Eisenberg, Eli

“…Abstract A-to-I RNA editing is an important post-transcriptional modification, known to be altered in tumors. It targets dozens of sites within miRNAs, some of…”
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Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance by Porath, Hagit T, Knisbacher, Binyamin A, Eisenberg, Eli, Levanon, Erez Y

“…Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional modification catalyzed by the ADAR (adenosine deaminase that acts on RNA) enzymes, which…”
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A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes by Bazak, Lily, Haviv, Ami, Barak, Michal, Jacob-Hirsch, Jasmine, Deng, Patricia, Zhang, Rui, Isaacs, Farren J, Rechavi, Gideon, Li, Jin Billy, Eisenberg, Eli, Levanon, Erez Y

“…RNA molecules transmit the information encoded in the genome and generally reflect its content. Adenosine-to-inosine (A-to-I) RNA editing by ADAR proteins…”
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A-to-I RNA Editing: An Overlooked Source of Cancer Mutations by Ben-Aroya, Shay, Levanon, Erez Y.

“…RNA editing is a source of transcriptomic diversity, mainly in non-coding regions, and is found to be altered in cancer. In this issue of Cancer Cell, Peng…”
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The New RNA-Editing Era – Ethical Considerations by Gold, Azgad, Levanon, Erez Y., Eisenberg, Eli

“…The characteristics of RNA editing, including the lower risk compared with genome editing, may loosen the ethical barriers that are currently imposed on…”
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Identification of recurrent regulated alternative splicing events across human solid tumors by Danan-Gotthold, Miri, Golan-Gerstl, Regina, Eisenberg, Eli, Meir, Keren, Karni, Rotem, Levanon, Erez Y

“…Cancer is a complex disease that involves aberrant gene expression regulation. Discriminating the modified expression patterns driving tumor biology from the…”
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Identification of widespread ultra-edited human RNAs by Carmi, Shai, Borukhov, Itamar, Levanon, Erez Y

“…Adenosine-to-inosine modification of RNA molecules (A-to-I RNA editing) is an important mechanism that increases transciptome diversity. It occurs when a…”
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Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease by Khermesh, Khen, D'Erchia, Anna Maria, Barak, Michal, Annese, Anita, Wachtel, Chaim, Levanon, Erez Y, Picardi, Ernesto, Eisenberg, Eli

“…Adenosine to inosine (A-to-I) RNA editing, catalyzed by the ADAR enzyme family, acts on dsRNA structures within pre-mRNA molecules. Editing of the coding part…”
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Landscape of adenosine-to-inosine RNA recoding across human tissues by Gabay, Orshay, Shoshan, Yoav, Kopel, Eli, Ben-Zvi, Udi, Mann, Tomer D., Bressler, Noam, Cohen‐Fultheim, Roni, Schaffer, Amos A., Roth, Shalom Hillel, Tzur, Ziv, Levanon, Erez Y., Eisenberg, Eli

“…RNA editing by adenosine deaminases changes the information encoded in the mRNA from its genomic blueprint. Editing of protein-coding sequences can introduce…”
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