Search Results - "Leval, Xavier de"

Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2 by BENOIT, Valérie, RELIC, Biserka, DE LEVAL, Xavier, CHARIOT, Alain, MERVILLE, Marie-Paule, BOURS, Vincent

“…The oncoprotein HER-2/neu is a prosurvival factor and its overexpression has been correlated with adverse prognosis in breast cancers. High levels of the…”
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Therapeutic potential of thromboxane inhibitors in asthma by Dogné, Jean-Michel, de Leval, Xavier, Benoit, Patricia, Rolin, Stephanie, Pirotte, Bernard, Masereel, Bernard

“…This paper reviews the role of thromboxane A(2) (TXA(2)) in the pathogenesis of pulmonary allergies, particularly asthma. The potential of TXA(2) modifiers in…”
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New trends in dual 5-LOX/COX inhibition by Leval, Xavier de, Julemont, Fabien, Delarge, Jacques, Pirotte, Bernard, Dogne, Jean-Michel

“…Dual inhibitors are drugs able to block both the COX and the 5-LOX metabolic pathways. The interest of developing such compounds is supported by a large number…”
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Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents by de Leval, Xavier, Dassesse, Thibaut, Dogné, Jean-Michel, Waltregny, David, Bellahcène, Akeila, Benoit, Valérie, Pirotte, Bernard, Castronovo, Vincent

“…Angiogenesis is a promising target for the therapy of several diseases including cancer. This study was undertaken to characterize the antiangiogenic…”
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Recent advances in inducible cyclooxygenase (COX-2) inhibition by de Leval, X, Delarge, J, Somers, F, de Tullio, P, Henrotin, Y, Pirotte, B, Dogné, J M

“…Cyclooxygenase is the key enzyme in the biosynthesis of prostanoids, biologically active substances that are involved in several physiological processes but…”
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New trends in thromboxane and prostacyclin modulators by Dogné, J M, de Leval, X, Delarge, J, David, J L, Masereel, B

“…Thromboxane A2 (TXA2) and prostacyclin (PGI2) are two labile products formed from arachidonic acid by the way of cyclooxygenase. An overproduction of…”
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Carbonic Anhydrase Inhibitors:  Synthesis and Topical Intraocular Pressure Lowering Effects of Fluorine-Containing Inhibitors Devoid of Enhanced Reactivity by de Leval, Xavier, Ilies, Monica, Casini, Angela, Dogné, Jean-Michel, Scozzafava, Andrea, Masini, Emanuela, Mincione, Francesco, Starnotti, Michele, Supuran, Claudiu T

“…Polyfluorinated carbonic anhydrase inhibitors (CAIs) show very good inhibitory properties against carbonic anhydrase (CA) and excellent in vivo antiglaucoma…”
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N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: Cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism by Renard, Jean-François, Lecomte, Frédéric, Hubert, Philippe, de Leval, Xavier, Pirotte, Bernard

“…Nimesulide, a COX-2 preferential inhibitor with a favorable gastric and cardiovascular safety profile, was responsible for some cases of acute liver failure…”
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Pyridine Analogues of Nimesulide: Design, Synthesis, and in Vitro and in Vivo Pharmacological Evaluation as Promising Cyclooxygenase 1 and 2 Inhibitors by Renard, Jean-François, Arslan, Deniz, Garbacki, Nancy, Pirotte, Bernard, de Leval, Xavier

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most prescribed medications, although the chronic use of such pharmacological agents is…”
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Activation of the thromboxane A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage by Dassesse, Thibaut, de Leval, Xavier, de Leval, Laurence, Pirotte, Bernard, Castronovo, Vincent, Waltregny, David

“…We investigated the potential involvement of the thromboxane A(2) (TXA(2)) pathway in human prostate cancer (PCa). Expression of cyclooxygenase-2 (COX-2),…”
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Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method by Michaux, Catherine, de Leval, Xavier, Julémont, Fabien, Dogné, Jean-Michel, Pirotte, Bernard, Durant, François

“…A four-point pharmacophore of COX-2 selective inhibitors was derived from a training set of 16 compounds, using the Catalyst program. It consists of a H bond…”
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New developments on thromboxane and prostacyclin modulators part II: prostacyclin modulators by de Leval, Xavier, Hanson, Julien, David, Jean-Louis, Masereel, Bernard, Pirotte, Bernard, Dogné, Jean-Michel

“…Prostacyclin (PGI(2)) is a potent endogenous inhibitor of platelet function and possesses a strong vasodilator effect. Furthermore, prostacyclin is currently…”
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Increased Expression of Bone Sialoprotein in Bone Metastases Compared with Visceral Metastases in Human Breast and Prostate Cancers by Waltregny, David, Bellahcène, Akeila, De Leval, Xavier, Florkin, Benoǐt, Weidle, Ulrich, Castronovo, Vincent

“…The recent demonstration that bone sialoprotein (BSP) is expressed in osteotropic cancers suggests that this bone matrix protein might be implicated in the…”
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New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators by Dogné, Jean-Michel, de Leval, Xavier, Hanson, Julien, Frederich, Michel, Lambermont, Bernard, Ghuysen, Alexandre, Casini, Angela, Masereel, Bernard, Ruan, Ke-He, Pirotte, Bernard, Kolh, Philippe

“…The pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic diseases can be related to arachidonic acid (AA) metabolites. One of…”
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From the design to the clinical application of thromboxane modulators by Dogné, Jean-Michel, Hanson, Julien, de Leval, Xavier, Pratico, Domenico, Pace-Asciak, Cecil R, Drion, Pierre, Pirotte, Bernard, Ruan, Ke-He

“…Arachidonic acid (AA) metabolites are key mediators involved in the pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic…”
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Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on bleeding time by Dogné, Jean-Michel, Hanson, Julien, de Leval, Xavier, Kolh, Philippe, Tchana-Sato, Vincent, de Leval, Laurence, Rolin, Stéphanie, Ghuysen, Alexandre, Segers, Patrick, Lambermont, Bernard, Masereel, Bernard, Pirotte, Bernard

“…The present study was undertaken to characterize the antiplatelet and antithrombotic effects of BM-573…”
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A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide by Michaux, Catherine, Charlier, Caroline, Julémont, Fabien, de Leval, Xavier, Dogné, Jean-Michel, Pirotte, Bernard, Durant, François

“…In this paper, the binding mode of original pyridinic compounds structurally related to nimesulide, a preferential cyclooxygenase (COX)-2 inhibitor, is…”
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Synthesis, molecular modelling and enzymatic evaluation of (±)3,5-diphenyl-2-thioxoimidazolidin-4-ones as new potential cyclooxygenase inhibitors by Gauthier, Marie P., Michaux, Catherine, Rolin, Stéphanie, Vastersaegher, Caroline, de Leval, Xavier, Julémont, Fabien, Pochet, Lionel, Masereel, Bernard

“…Substituted (±)2-thioxoimidazolin-4-ones were synthesized in order to design new type-2 cyclooxygenase (COX-2) inhibitors. Some of them completely inhibit…”
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Effects of COX-2 inhibitors on ROS produced by Chlamydia pneumoniae-primed human promonocytic cells (THP-1) by Mouithys-Mickalad, Ange, Deby-Dupont, Ginette, Dogne, Jean-Michel, de Leval, Xavier, Kohnen, Stephan, Navet, Rachel, Sluse, Francis, Hoebeke, Maryse, Pirotte, Bernard, Lamy, Maurice

“…Chronic inflammation through foam cells and macrophages is important in atherosclerosis development, and can be considered as therapeutic targets…”
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Spectral and Crystallographic Study of Pyridinic Analogues of Nimesulide: Determination of the Active Form of Methanesulfonamides as COX-2 Selective Inhibitors by Julémont, Fabien, de Leval, Xavier, Michaux, Catherine, Damas, Jacques, Charlier, Caroline, Durant, François, Pirotte, Bernard, Dogné, Jean-Michel

“…Compound 7, N-(3-phenoxy-4-pyridinyl)trifluoromethanesulfonamide, showed in vitro (whole blood assay) a strong inhibitory activity on the two cyclooxygenase…”
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