Search Results - "Lev, P. R."

Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets by Glembotsky, A. C., Bluteau, D., Espasandin, Y. R., Goette, N. P., Marta, R. F., Marin Oyarzun, C. P., Korin, L., Lev, P. R., Laguens, R. P., Molinas, F. C., Raslova, H., Heller, P. G.

“…Summary Background Familial platelet disorder with a predisposition to acute myelogenous leukemia (FPD/AML) is an inherited platelet disorder caused by a…”
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Anagrelide platelet‐lowering effect is due to inhibition of both megakaryocyte maturation and proplatelet formation: insight into potential mechanisms by Espasandin, Y. R., Glembotsky, A. C., Grodzielski, M., Lev, P. R., Goette, N. P., Molinas, F. C., Marta, R. F., Heller, P. G.

“…Summary Background and Objectives Anagrelide represents a treatment option for essential thrombocythemia patients. It lowers platelet counts through inhibition…”
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Variation of PDGF, TGFβ, and bFGF levels in essential thrombocythemia patients treated with anagrelide by Lev, P.R., Marta, R.F., Vassallu, P., Molinas, F.C.

“…We studied 15 patients with essential thrombocythemia (ET) before treatment and after normalization of platelet count by anagrelide. Significantly increased…”
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Production of functional platelet-like particles by the megakaryoblastic DAMI cell line provides a model for platelet biogenesis by Lev, P. R., Goette, N. P., Glembotsky, A. C., Laguens, R. P., Meckert, P. M. Cabeza, Salim, J. P., Heller, P. G., Pozner, R. G., Marta, R. F., Molinas, F. C.

“…The aim of this study was to evaluate cell maturation and the platelet production capacity of the megakaryoblastic DAMI cell line, to characterize…”
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Diverse Mpl expression pattern among pedigrees with inherited thrombocytopenia: potential diagnostic and therapeutic implications by HELLER, P. G., GLEMBOTSKY, A. C., GOETTE, N. P., MARTA, R. F., LEV, P. R., MOLINAS, F. C.

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Platelets possess functional TGF-β receptors and Smad2 protein by Lev, P. R., Salim, J. P., Marta, R. F., Mela Osorio, M. J., Goette, N. P., Molinas, F. C.

“…TGF-β1 plays a main role in tissue repair by regulating extracellular matrix production and tissue granulation. Platelets are one of the main sources of this…”
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Monocyte IL-2Rα expression is associated with thrombosis and the JAK2V617F mutation in myeloproliferative neoplasms by Goette, N.P., Lev, P.R., Heller, P.G., Kornblihtt, L.I., Korin, L., Molinas, F.C., Marta, R.F.

“…The development of bone marrow fibrosis and thrombosis are main causes of morbidity in essential thrombocythemia (ET). Monocyte activation has been associated…”
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Monocyte IL-2Ralpha expression is associated with thrombosis and the JAK2V617F mutation in myeloproliferative neoplasms by Goette, N P, Lev, P R, Heller, P G, Kornblihtt, L I, Korin, L, Molinas, F C, Marta, R F

“…The development of bone marrow fibrosis and thrombosis are main causes of morbidity in essential thrombocythemia (ET). Monocyte activation has been associated…”
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Platelets possess functional TGF- receptors and Smad2 protein by Lev, P. R., Salim, J. P., Marta, R. F., Mela Osorio, M. J., Goette, N. P., Molinas, F. C.

“…TGF- 1 plays a main role in tissue repair by regulating extracellular matrix production and tissue granulation. Platelets are one of the main sources of this…”
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Variation of PDGF, TGFbeta, and bFGF levels in essential thrombocythemia patients treated with anagrelide by Lev, P R, Marta, R F, Vassallu, P, Molinas, F C

“…We studied 15 patients with essential thrombocythemia (ET) before treatment and after normalization of platelet count by anagrelide. Significantly increased…”
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Normal platelets possess the soluble form of IL-6 receptor by Marta, Rosana F., Goette, Nora P., Lev, Paola R., Chazarreta, Carlos D., Pirola, Carlos J., Molinas, Felisa C.

“…Interleukin 6 is a multifunctional cytokine that exerts its biological activity through binding to an 80 Kd specific receptor (IL-6Rα) and a 130 Kd…”
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PDGF‐A, PDGF‐B, TGFβ, and bFGF mRNA levels in patients with essential thrombocythemia treated with anagrelide by Lev, Paola R., Salim, Juan P., Kornblihtt, Laura I., Pirola, Carlos J., Marta, Rosana F., Heller, Paula G., Molinas, Felisa C.

“…Plasmatic levels of PDGF‐AB, TGFβ1, and bFGF are increased in patients with essential thrombocythemia (ET) while intraplatelet levels are low for PDGF, normal…”
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