Search Results - "Leusen, Jeanette"

Targeted Delivery of a Sialic Acid-Blocking Glycomimetic to Cancer Cells Inhibits Metastatic Spread by Büll, Christian, Boltje, Thomas Jan, van Dinther, Eric A. W, Peters, Timo, de Graaf, Annemarie M. A, Leusen, Jeanette H. W, Kreutz, Martin, Figdor, Carl G, den Brok, Martijn H, Adema, Gosse J

“…Sialic acid sugars are overexpressed by cancer cells and contribute to the metastatic cascade at multiple levels. Therapeutic interference of sialic acids,…”
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Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy by Logtenberg, Meike E. W., Jansen, J. H. Marco, Raaben, Matthijs, Toebes, Mireille, Franke, Katka, Brandsma, Arianne M., Matlung, Hanke L., Fauster, Astrid, Gomez-Eerland, Raquel, Bakker, Noor A. M., van der Schot, Simone, Marijt, Koen A., Verdoes, Martijn, Haanen, John B. A. G., van den Berg, Joost H., Neefjes, Jacques, van den Berg, Timo K., Brummelkamp, Thijn R., Leusen, Jeanette H. W., Scheeren, Ferenc A., Schumacher, Ton N.

“…Cancer cells can evade immune surveillance through the expression of inhibitory ligands that bind their cognate receptors on immune effector cells. Expression…”
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Crosstalk between human IgG isotypes and murine effector cells by Overdijk, Marije B, Verploegen, Sandra, Ortiz Buijsse, Antonio, Vink, Tom, Leusen, Jeanette H W, Bleeker, Wim K, Parren, Paul W H I

“…Development of human therapeutic Abs has led to reduced immunogenicity and optimal interactions with the human immune system in patients. Humanization had as a…”
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Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer by Meyer, Saskia, Leusen, Jeanette HW, Boross, Peter

“…The complement system is a powerful tool of the innate immune system to eradicate pathogens. Both in vitro and in vivo evidence indicates that therapeutic…”
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DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo by Lehmann, Christian H K, Baranska, Anna, Heidkamp, Gordon F, Heger, Lukas, Neubert, Kirsten, Lühr, Jennifer J, Hoffmann, Alana, Reimer, Katharina C, Brückner, Christin, Beck, Simone, Seeling, Michaela, Kießling, Melissa, Soulat, Didier, Krug, Anne B, Ravetch, Jeffrey V, Leusen, Jeanette H W, Nimmerjahn, Falk, Dudziak, Diana

“…Dendritic cells (DCs) are efficient antigen-presenting cells equipped with various cell surface receptors for the direct or indirect recognition of pathogenic…”
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The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking by Overdijk, Marije B, Jansen, J H Marco, Nederend, Maaike, Lammerts van Bueren, Jeroen J, Groen, Richard W J, Parren, Paul W H I, Leusen, Jeanette H W, Boross, Peter

“…Emerging evidence suggests that FcγR-mediated cross-linking of tumor-bound mAbs may induce signaling in tumor cells that contributes to their therapeutic…”
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Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab by Golay, Josée, Da Roit, Fabio, Bologna, Luca, Ferrara, Claudia, Leusen, Jeanette H., Rambaldi, Alessandro, Klein, Christian, Introna, Martino

“…Obinutuzumab (GA101) is a glycoengineered type 2 CD20 antibody with enhanced CD16A-binding and natural killer–mediated cytotoxicity. CD16B is highly homologous…”
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Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG by Brandsma, Arianne M, Bondza, Sina, Evers, Mitchell, Koutstaal, Rosanne, Nederend, Maaike, Jansen, J H Marco, Rösner, Thies, Valerius, Thomas, Leusen, Jeanette H W, Ten Broeke, Toine

“…Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life expectancy. Except for immune checkpoint inhibition, the mode of…”
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Clarifying the Confusion between Cytokine and Fc Receptor “Common Gamma Chain” by Brandsma, Arianne M., Hogarth, P. Mark, Nimmerjahn, Falk, Leusen, Jeanette H.W.

“…All γc cytokines have different functions in the immune system, although they use the same γc. Binding of a cytokine to its receptor activates the associated…”
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IgA as therapeutic antibody by Leusen, Jeanette H.W.

“…•IgA is a very promising isotype for antibody therapeutics.•This review will discuss several IgA-based formats and future directives. This review is focused on…”
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ARGX-117, a therapeutic complement inhibiting antibody targeting C2 by Van de Walle, Inge, Silence, Karen, Budding, Kevin, Van de Ven, Liesbeth, Dijkxhoorn, Kim, de Zeeuw, Elisabeth, Yildiz, Cafer, Gabriels, Sofie, Percier, Jean-Michel, Wildemann, Johanna, Meeldijk, Jan, Simons, Peter J., Boon, Louis, Cox, Linda, Holgate, Rob, Urbanus, Rolf, Otten, Henny G., Leusen, Jeanette H.W., Blanchetot, Christophe, de Haard, Hans, Hack, C. Erik, Boross, Peter

“…Activation of the classical and lectin pathway of complement may contribute to tissue damage and organ dysfunction of antibody-mediated diseases and…”
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Targeting the myeloid microenvironment in neuroblastoma by Stip, Marjolein C, Teeuwen, Loes, Dierselhuis, Miranda P, Leusen, Jeanette H W, Krijgsman, Daniëlle

“…Myeloid cells (granulocytes and monocytes/macrophages) play an important role in neuroblastoma. By inducing a complex immunosuppressive network, myeloid cells…”
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Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions by Baumann, Niklas, Rösner, Thies, Jansen, J. H. Marco, Chan, Chilam, Marie Eichholz, Klara, Klausz, Katja, Winterberg, Dorothee, Müller, Kristina, Humpe, Andreas, Burger, Renate, Peipp, Matthias, Schewe, Denis M., Kellner, Christian, Leusen, Jeanette H. W., Valerius, Thomas

“…Integrin associated protein (CD47) is an important target in immunotherapy, as it is expressed as a “don't eat me” signal on many tumor cells. Interference…”
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Characterization of human Fc alpha receptor transgenic mice: comparison of CD89 expression and antibody-dependent tumor killing between mouse strains by Stip, Marjolein C., Jansen, J. H. Marco, Nederend, Maaike, Tsioumpekou, Maria, Evers, Mitchell, Olofsen, Patricia A., Meyer-Wentrup, Friederike, Leusen, Jeanette H. W.

“…Since mice do not express a homologue of the human Fc alpha receptor (FcαRI or CD89), a transgenic mouse model was generated in four different backgrounds…”
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Fc receptor inside-out signaling and possible impact on antibody therapy by Brandsma, Arianne M., Jacobino, Shamir R., Meyer, Saskia, ten Broeke, Toine, Leusen, Jeanette H. W.

“…Summary Fc receptors (FcR) are expressed on immune cells and bind to the Fc tail of antibodies. This interaction is essential for FcR‐mediated signaling and…”
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Functional characteristics of the high affinity IgG receptor, FcγRI by van der Poel, Cees E, Spaapen, Robbert M, van de Winkel, Jan G J, Leusen, Jeanette H W

“…IgG FcRs are important mediators of immunity and play a key role during Ab-based immunotherapy. Within the leukocyte IgG receptor family, only FcγRI is capable…”
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The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease by Tsioumpekou, Maria, Krijgsman, Daniëlle, Leusen, Jeanette H W, Olofsen, Patricia A

“…Neutrophils are crucial innate immune cells and comprise 50-70% of the white blood cell population under homeostatic conditions. Upon infection and in cancer,…”
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Combining Cellular Immunization and Phage Display Screening Results in Novel, FcγRI-Specific Antibodies by Krohn, Steffen, Holtrop, Tosca, Brandsma, Arianne M, Moerer, Petra, Nederend, Maaike, Darzentas, Nikos, Brüggemann, Monika, Klausz, Katja, Leusen, Jeanette H W, Peipp, Matthias

“…Antibodies that specifically bind to individual human fragment crystallizable γ receptors (FcγRs) are of interest as research tools in studying immune cell…”
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IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice by Todorova, Biliana, Godon, Ophélie, Conde, Eva, Gillis, Caitlin M., Iannascoli, Bruno, Richard-Le Goff, Odile, Fiole, Daniel, Roumenina, Lubka T., Leusen, Jeanette H. W., Murphy, Andrew J., Macdonald, Lynn E., Reber, Laurent L., Jönsson, Friederike, Bruhns, Pierre

“…Abstract Mouse models of active systemic anaphylaxis rely predominantly on IgG Abs forming IgG–allergen immune complexes that induce IgG receptor–expressing…”
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CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping by Bras, Anne E., Haas, Valerie, Stigt, Arthur, Jongen‐Lavrencic, Mojca, Beverloo, H. Berna, Marvelde, Jeroen G., Zwaan, C. Michel, Dongen, Jacques J.M., Leusen, Jeanette H.W., Velden, Vincent H.J.

“…Background While it is known that CD123 is normally strongly expressed on plasmacytoid dendritic cells and completely absent on nucleated red blood cells,…”
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