Search Results - "Leus, Niek G. J."

HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice by Leus, Niek G. J., van den Bosch, Thea, van der Wouden, Petra E., Krist, Kim, Ourailidou, Maria E., Eleftheriadis, Nikolaos, Kistemaker, Loes E. M., Bos, Sophie, Gjaltema, Rutger A. F., Mekonnen, Solomon A., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.

“…Chronic obstructive pulmonary disease (COPD) constitutes a major health burden. Studying underlying molecular mechanisms could lead to new therapeutic targets…”
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Anti-VCAM‑1 and Anti-E-selectin SAINT-O-Somes for Selective Delivery of siRNA into Inflammation-Activated Primary Endothelial Cells by Kowalski, Piotr S, Lintermans, Lucas L, Morselt, Henriëtte W. M, Leus, Niek G. J, Ruiters, Marcel H. J, Molema, Grietje, Kamps, Jan A. A. M

“…Activated endothelial cells play a pivotal role in the pathology of inflammatory diseases and present a rational target for therapeutic intervention by…”
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Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo by Kowalski, Piotr S., Zwiers, Peter J., Morselt, Henriëtte W.M., Kuldo, Joanna M., Leus, Niek G.J., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.

“…The pivotal role of endothelial cells in the pathology of inflammatory diseases raised interest in the development of short interfering RNA (siRNA) delivery…”
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VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression by Leus, Niek G.J., Morselt, Henriëtte W.M., Zwiers, Peter J., Kowalski, Piotr S., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.

“…[Display omitted] In recent years much research in RNA nanotechnology has been directed to develop an efficient and clinically suitable delivery system for…”
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Targeted siRNA delivery to diseased microvascular endothelial cells—Cellular and molecular concepts by Kowalski, Piotr S., Leus, Niek G. J., Scherphof, Gerrit L., Ruiters, Marcel H. J., Kamps, Jan A. A. M., Molema, Grietje

“…Increased insight in the role of endothelial cells in the pathophysiology of cancer, inflammatory and cardiovascular diseases, has drawn great interest in…”
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Reassessment of the Role of Mut S Homolog 5 in Ig Class Switch Recombination Shows Lack of Involvement in cis- and trans-Switching by Guikema, Jeroen E. J, Schrader, Carol E, Leus, Niek G. J, Ucher, Anna, Linehan, Erin K, Werling, Uwe, Edelmann, Winfried, Stavnezer, Janet

“…When B cells are activated after immunization or infection, they exchange the gene encoding the Ig H chain C region by class switch recombination (CSR). CSR…”
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HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity by Leus, Niek G.J., van der Wouden, Petra E., van den Bosch, Thea, Hooghiemstra, Wouter T.R., Ourailidou, Maria E., Kistemaker, Loes E.M., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.

“…[Display omitted] The increasing number of patients suffering from chronic obstructive pulmonary disease (COPD) represents a major and increasing health…”
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Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation by Leus, Niek GJ, Zwinderman, Martijn RH, Dekker, Frank J

“…[Display omitted] •HDAC 3 plays a key role in NF-κB-mediated signaling.•HDAC inhibitors demonstrate promising anti-inflammatory effects.•Selective HDAC 3…”
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Rational Development of a Potent 15-Lipoxygenase‑1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties by Eleftheriadis, Nikolaos, Neochoritis, Constantinos G., Leus, Niek G. J., van der Wouden, Petra E., Dömling, Alexander, Dekker, Frank J.

“…Human 15-lipoxygenase-1 (h-15-LOX-1) is a mammalian lipoxygenase and plays an important role in several inflammatory lung diseases such as asthma, COPD, and…”
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The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases by van den Bosch, Thea, Boichenko, Alexander, Leus, Niek G.J., Ourailidou, Maria E., Wapenaar, Hannah, Rotili, Dante, Mai, Antonello, Imhof, Axel, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.

“…[Display omitted] Lysine acetylations are reversible posttranslational modifications of histone and non-histone proteins that play important regulatory roles…”
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Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties by Eleftheriadis, Nikolaos, Poelman, Hessel, Leus, Niek G.J., Honrath, Birgit, Neochoritis, Constantinos G., Dolga, Amalia, Dömling, Alexander, Dekker, Frank J.

“…The enzyme 15-lipoxygenase-1 (15-LOX-1) plays a dual role in diseases with an inflammatory component. On one hand 15-LOX-1 plays a role in pro-inflammatory…”
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Activity-Based Probes for 15-Lipoxygenase-1 by Eleftheriadis, Nikolaos, Thee, Stephanie A., Zwinderman, Martijn R. H., Leus, Niek G. J., Dekker, Frank J.

“…Human 15‐lipoxygenase‐1 (15‐LOX‐1) plays an important role in several inflammatory lung diseases, such as asthma, COPD, and chronic bronchitis, as well as…”
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A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices by van den Bosch, Thea, Leus, Niek G.J, Wapenaar, Hannah, Boichenko, Alexander, Hermans, Jos, Bischoff, Rainer, Haisma, Hidde J, Dekker, Frank J

“…Abstract Lysine acetylations are post-translational modifications of cellular proteins, that are crucial in the regulation of many cellular processes. Lysine…”
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Activity-Based Probes for 15-Lipoxygenase-1 by Eleftheriadis, Nikolaos, Thee, Stephanie A., Zwinderman, Martijn R. H., Leus, Niek G. J., Dekker, Frank J.

“…Human 15‐lipoxygenase‐1 (15‐LOX‐1) plays an important role in several inflammatory lung diseases, such as asthma, COPD, and chronic bronchitis, as well as…”
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The relevance of K i calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor by Wapenaar, Hannah, van den Bosch, Thea, Leus, Niek G J, van der Wouden, Petra E, Eleftheriadis, Nikolaos, Hermans, Jos, Hailu, Gebremedhin Solomon, Rotili, Dante, Mai, Antonello, Dömling, Alexander, Bischoff, Rainer, Haisma, Hidde J, Dekker, Frank J

“…Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and…”
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The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor by Wapenaar, Hannah, van den Bosch, Thea, Leus, Niek G.J., van der Wouden, Petra E., Eleftheriadis, Nikolaos, Hermans, Jos, Hailu, Gebremedhin Solomon, Rotili, Dante, Mai, Antonello, Dömling, Alexander, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.

“…Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and…”
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Effective siRNA delivery to inflamed primary vascular endothelial cells by anti-E-selectin and anti-VCAM-1 PEGylated SAINT-based lipoplexes by Leus, Niek G.J., Talman, Eduard G., Ramana, Pranov, Kowalski, Piotr S., Woudenberg-Vrenken, Titia E., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.

“…PEGylated anti-E-selectin and anti-VCAM-1-SAINTPEGarg are effective devices for siRNA delivery into the inflammation-activated primary endothelial cells (ECs)…”
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ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination by Khair, Lyne, Guikema, Jeroen E J, Linehan, Erin K, Ucher, Anna J, Leus, Niek G J, Ogilvie, Colin, Lou, Zhenkun, Schrader, Carol E, Stavnezer, Janet

“…Activation-induced cytidine deaminase (AID) initiates Ab class-switch recombination (CSR) in activated B cells resulting in exchanging the IgH C region and…”
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SAINT-liposome-polycation particles, a new carrier for improved delivery of siRNAs to inflamed endothelial cells by Kowalski, Piotr S., Kuninty, Praneeth R., Bijlsma, Klaas T., Stuart, Marc C.A., Leus, Niek G.J., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.

“…•Design of new SAINT-C18 and protamine based carriers for siRNA delivery.•High siRNA encapsulation and low cellular toxicity.•Stability and siRNA integrity…”
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Reassessment of the Role of Mut S Homolog 5 in Ig Class Switch Recombination Shows Lack of Involvement in cis- and trans-Switching1 by Guikema, Jeroen E. J., Schrader, Carol E., Leus, Niek G. J., Ucher, Anna, Linehan, Erin K., Werling, Uwe, Edelmann, Winfried, Stavnezer, Janet

“…When B cells are activated after immunization or infection, they exchange the gene encoding the Ig H chain C region by class switch recombination (CSR). CSR…”
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