Search Results - "Leupin, Werner"

Protonation Equilibria of Hoechst 33258 in Aqueous Solution by Ladinig, Manfred, Leupin, Werner, Meuwly, Markus, Respondek, Michal, Wirz, Jakob, Zoete, Vincent

“…The bis‐benzimidazole derivative Hoechst 33258 (2′‐(4‐hydroxyphenyl)‐5‐(4‐methylpiperazin‐1‐yl)‐2,5′‐bi‐1H‐benzimidazole) binds to the minor groove of DNA…”
Get full text

Low-lying electronically excited states of cycl[3.3.3]azine, a bridged 12.pi.-perimeter by Leupin, Werner, Wirz, Jakob

Get full text

Two-dimensional proton nuclear magnetic resonance investigation of the synthetic deoxyribonucleic acid decamer d(ATATCGATAT) by Feigon, Juli, Leupin, Werner, Denny, William A, Kearns, David R

Get full text

Tris-benzimidazole derivatives : Design, synthesis and DNA sequence recognition by JI, Yu-Hua, BUR, Daniel, HÄSLER, Walter, SCHMITT, Valérie Runtz, DORN, Arnulf, BAILLY, Christian, WARING, Michael J, HOCHSTRASSER, Remo, LEUPIN, Werner

“…Two tris-benzimidazole derivatives have been designed and synthesized based on the known structures of the bis-benzimidazole stain Hoechst 33258 complexed to…”
Get full text

1,4,7-Triazacycl[3.3.3]azine: basicity, photoelectron spectrum, photophysical properties by Leupin, Werner, Magde, Douglas, Persy, Gabriele, Wirz, Jakob

Get full text

Hydration of DNA in aqueous solution: NMR evidence for a kinetic destabilization of the minor groove hydration of d-(TTAA)2 versus d-(AATT)2 segments by Liepinsh, Edvards, Leupin, Werner, Otting, Gottfried

“…The residence times of the hydration water molecules near the base protons of d-(GTGGAATTCCAC)2 and d-(GTGGTTAACCAC)2 were investigated by nuclear magnetic…”
Get full text

Determination of the NMR solution structure of the Hoechst 33258-d(GTGGAATTCCAC)2 complex and comparison with the X-ray crystal structure by Fede, A, Billeter, M, Leupin, W, Wüthrich, K

“…The chromosomal stain, Hoechst 33258, binds to the minor groove of the DNA double helix and specifically recognizes a run of four A-T base pairs. Extensive…”
Get more information

Designer DNA-Binding Drugs: The Crystal Structure of a Meta-Hydroxy Analogue of Hoechst 33258 Bound to d(CGCGAATTCGCG)2 by Clark, George R., Squire, Christopher J., Gray, Emily J., Leupin, Werner, Neidle, Stephen

“…An analogue of the DNA binding compound Hoechst 33258, which has the para hydroxyl group altered to be at the meta position, together with the replacement of…”
Get full text

Minor Groove Hydration of DNA in Aqueous Solution: Sequence-dependent Next Neighbor Effect of the Hydration Lifetimes in d(TTAA)2 Segments Measured by NMR Spectroscopy by Jacobson, Anders, Leupin, Werner, Liepinsh, Edvards, Otting, Gottfried

“…The hydration in the minor groove of double stranded DNA fragments containing the sequences 5′-dTTAAT, 5′-dTTAAC, 5′-dTTAAA and 5′-dTTAAG was investigated by…”
Get full text

DNA Binding Properties of the Purified Antennapedia Homeodomain by Affolter, Markus, Percival-Smith, Anthony, Muller, Martin, Leupin, Werner, Gehring, Walter J.

“…The in vitro DNA binding properties of a purified 68-amino acid Antennapedia homeodomain (Antp HD) peptide have been analyzed. Equilibrium and kinetic binding…”
Get full text

Isohelicity and Phasing in Drug−DNA Sequence Recognition:  Crystal Structure of a Tris(benzimidazole)−Oligonucleotide Complex by Clark, George R, Gray, Emily J, Neidle, Stephen, Li, Yu-Hua, Leupin, Werner

“…The crystal structure is reported of a tris(benzimidazole) analogue of the minor-groove drug Hoechst 33258 bound to the sequence d(CGCAAATTTGCG)2. The…”
Get full text

Distamycin-induced inhibition of homeodomain--DNA complexes by Dorn, A, Affolter, M, Muller, M, Gehring, W.J, Leupin, W

“…The mobility shift assay was used to study the competition of the minor groove binder distamycin A with either an Antennapedia homeodomain (Antp HD) peptide or…”
Get full text

The Width of the Minor Groove Affects the Binding of the Bisquaternary Heterocycle SN-6999 to Duplex DNA by Rydzewski, Jan M., Leupin, Werner, Chazin, Walter

“…A complex between d(GGGAAAAACGG)·d(CCGTTTTTCCC) and the minor groove binding drug SN-6999 has been studied by 1H nuclear magnetic resonance spectroscopy. The…”
Get full text

Two-dimensional proton nuclear magnetic resonance investigation of the synthetic deoxyribonucleic acid decamer d(ATATCGATAT)2 by FEIGON, J, LEUPIN, W, DENNY, W. A, KEARNS, D. R

“…In this study two-dimensional NMR techniques (COSY and NOESY) have been used in conjunction with one-dimensional NMR results to complete the assignment of the…”
Get full text

NMR studies of DNA duplexes singly cross-linked by different synthetic linkers by Altmann, Serge, Labhardt, Alexander M., Bur, Daniel, Lehmann, Christain, Bannwarth, Willi, Billeter, Martin, Wüthrich, Kurt, Leupin, Werner

“…Molecular modelling studies resulted in the design of a variety of non-nucleotidic covalent linkers to bridge the 3′-end of the (+)-strand and the 5′-end of…”
Get full text

Two-dimensional NMR studies of d(GGTTAATGCGGT).d-(ACCGCATTAACC) complexed with the minor groove binding drug SN-6999 by SHIOW-MEEI CHEN, LEUPIN, W, CHAZIN, W. J

“…The dodecadeoxynucleotide duplex d(GGTTAATGCGGT).d(ACCGCATTAACC) and its 1:1 complex with the minor groove binding drug SN-6999 have been prepared and studied…”
Get full text

Homeodomain proteins in development and therapy by Dorn, A, Affolter, M, Gehring, W J, Leupin, W

“…Homeobox genes encode transcriptional regulators found in all organisms ranging from yeast to humans. In Drosophila, a specific class of homeobox genes, the…”
Get more information

Synthesis of pyrene—acridine bis-intercalators and effects of binding to DNA by Bassani, Dario M., Wirz, Jakob, Hochstrasser, Remo, Leupin, Werner

“…A bis-intercalating compound containing pyrene and 9-aminoacridine chromophores ( N-(5-(1-pyrenyl)-pentyl)-6-(9-acridinylamino) hexylamide, I), was prepared…”
Get full text

Dynamics and binding mode of Hoechst 33258 to d(GTGGAATTCCAC)2 in the 1:1 solution complex as determined by two-dimensional proton NMR by Fede, Agostino, Labhardt, Alexander, Bannwarth, Willi, Leupin, Werner

Get full text

Two-dimensional NMR studies of d(GGTTAATGCGGT).cntdot.d(ACCGCATTAACC) complexed with the minor groove binding drug SN-6999 by Chen, Shiow Meei, Leupin, Werner, Rance, Mark, Chazin, Walter J

Get full text