Search Results - "Leung, S.C."

The autoimmune basis of alopecia areata: A comprehensive review by Islam, Naseeha, Leung, Patrick S.C, Huntley, Arthur C, Eric Gershwin, M

“…Abstract Alopecia areata (AA) is a common, non-scarring dermatologic condition regularly distinguished by patches of hair loss on the scalp also manifesting in…”
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Mechanisms of environmental influence on human autoimmunity: A national institute of environmental health sciences expert panel workshop by Selmi, Carlo, Leung, Patrick S.C, Sherr, David H, Diaz, Marilyn, Nyland, Jennifer F, Monestier, Marc, Rose, Noel R, Gershwin, M.Eric

“…Abstract The mechanisms leading to autoimmune diseases remain largely unknown despite numerous lines of experimental inquiry and epidemiological evidence. The…”
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Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity by Vogel, Christoph F A, Chang, W L William, Kado, Sarah, McCulloh, Kelly, Vogel, Helena, Wu, Dalei, Haarmann-Stemmann, Thomas, Yang, GuoXiang, Leung, Patrick S C, Matsumura, Fumio, Gershwin, M Eric

“…The aryl hydrocarbon receptor repressor (AhRR) is known to repress aryl hydrocarbon receptor (AhR) signaling, but very little is known regarding the role of…”
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Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases by Li, You, Tang, Ruqi, Leung, Patrick S.C., Gershwin, M. Eric, Ma, Xiong

“…Autoimmune cholestatic liver diseases, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are manifested as an impairment of…”
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The Genetics and Epigenetics of Primary Biliary Cholangitis by Tanaka, Atsushi, MD, Leung, Patrick S.C., PhD, Gershwin, Merrill Eric, MD

“…Both genetic background and environmental factors contribute to primary biliary cholangitis (PBC). Recent innovative technologies, such as genome-wide…”
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Environment and primary biliary cirrhosis: Electrophilic drugs and the induction of AMA by Leung, Patrick S.C, Wang, Jinjun, Naiyanetr, Phornnop, Kenny, Thomas P, Lam, Kit S, Kurth, Mark J, Gershwin, M. Eric

“…Abstract Environmental stimulation is a major factor in the initiation and perpetuation of autoimmune diseases. We have addressed this issue and focused on…”
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Autotaxin, Pruritus and Primary Biliary Cholangitis (PBC) by Sun, Ying, Zhang, Weici, Evans, Jilly F, Floreani, Annarosa, Zou, Zhengsheng, Nishio, Yukiko, Qi, Ruizhao, Leung, Patrick S.C, Bowlus, Christopher L, Gershwin, M. Eric

“…Abstract Autotaxin (ATX) is a 125-kD type II ectonucleotide pyrophosphatase/phosphodiesterase (ENPP2 or NPP2) originally discovered as an unknown “autocrine…”
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Gastrointestinal Immune Response to the Shrimp Allergen Tropomyosin: Histological and Immunological Analysis in an Animal Model of Shrimp Tropomyosin Hypersensitivity by Lam, Yin Fan, Tong, Ka Kui, Kwan, Kin Ming, Tsuneyama, Koichi, Shu, Shang-An, Leung, Patrick S C, Chu, Ka Hou

“…Shellfish hypersensitivity is among the most common food allergies. A murine model of IgE-mediated shrimp allergy has been established in our laboratory. The…”
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Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis by Chen, Richy C.Y., Naiyanetr, Phornnop, Shu, Shang‐An, Wang, Jinjun, Yang, Guo‐Xiang, Kenny, Thomas P., Guggenheim, Kathryn C., Butler, Jeffrey D., Bowlus, Christopher, Tao, Mi‐Hua, Kurth, Mark J., Ansari, Aftab A., Kaplan, Marshall, Coppel, Ross L., Lleo, Ana, Gershwin, M. Eric, Leung, Patrick S.C.

“…Antimitochondrial antibodies (AMAs) directed against the lipoyl domain of the E2 subunit of pyruvate dehydrogenase (PDC‐E2) are detected in 95% of patients…”
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The immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1) by Guo, Can-Jie, Leung, Patrick S.C., Zhang, Weici, Ma, Xiong, Gershwin, M. Eric

“…Autoimmune Polyglandular Syndrome type 1 (APS-1) is a subtype of the autoimmune polyendocrine syndrome characterized by the simultaneous or sequential…”
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IL‐12/Th1 and IL‐23/Th17 biliary microenvironment in primary biliary cirrhosis: Implications for therapy by Yang, Chen‐Yen, Ma, Xiong, Tsuneyama, Koichi, Huang, Shanshan, Takahashi, Toru, Chalasani, Naga P., Bowlus, Christopher L., Yang, Guo‐Xiang, Leung, Patrick S.C., Ansari, Aftab A., Wu, Linda, Coppel, Ross L., Gershwin, M. Eric

“…The interleukin (IL)‐12/IL‐23‐mediated Th1/Th17 signaling pathway has been associated with the etiopathogenesis of primary biliary cirrhosis (PBC). To address…”
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The myristoylated alanine-rich C-kinase substrates (MARCKS): A membrane-anchored mediator of the cell function by Chen, Zhilei, Zhang, Weici, Selmi, Carlo, Ridgway, William M., Leung, Patrick S.C., Zhang, Fengchun, Gershwin, M. Eric

“…The myristoylated alanine-rich C-kinase substrate (MARCKS) and the MARCKS-related protein (MARCKSL1) are ubiquitous, highly conserved membrane-associated…”
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Overcoming Shellfish Allergy: How Far Have We Come? by Wai, Christine Y Y, Leung, Nicki Y H, Chu, Ka Hou, Leung, Patrick S C, Leung, Agnes S Y, Wong, Gary W K, Leung, Ting Fan

“…Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the…”
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The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex‐biased autoimmunity by Bae, Heekyong R., Hodge, Deborah L., Yang, Guo‐Xiang, Leung, Patrick S.C., Chodisetti, Sathi Babu, Valencia, Julio C., Sanford, Michael, Fenimore, John M., Rahman, Ziaur S.M., Tsuneyama, Koichi, Norman, Gary L., Gershwin, M. Eric, Young, Howard A.

“…We have reported on a murine model of autoimmune cholangitis, generated by altering the AU‐rich element (ARE) by deletion of the interferon gamma (IFN‐γ) 3'…”
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Primary biliary cirrhosis and the nuclear pore complex by Duarte-Rey, Carolina, Bogdanos, Dimitrios, Yang, Chen-Yen, Roberts, Krista, Leung, Patrick S.C, Anaya, Juan-Manuel, Worman, Howard J, Gershwin, M. Eric

“…Abstract Experimental models of autoimmune diseases have led to the conclusion that an immune response to nuclear antigens is a sentinel marker for loss of…”
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Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? by Leung, Patrick S.C, Lam, Kit, Kurth, Mark J, Coppel, Ross L, Gershwin, M. Eric

“…The serologic hallmark of primary biliary cirrhosis (PBC) is the presence of antimitochondrial autoantibodies (AMAs) directed against the E2 subunit of the…”
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Recurrence of disease following organ transplantation in autoimmune liver disease and systemic lupus erythematosus by Tanaka, Atsushi, Kono, Hajime, Leung, Patrick S.C., Gershwin, M. Eric

“…•Organ transplantation is the most effective treatment for end-stage autoimmune diseases.•Disease recurrence after organ transplantation is a major clinical…”
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Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity by Naiyanetr, Phornnop, Butler, Jeffrey D, Meng, Liping, Pfeiff, Janice, Kenny, Thomas P, Guggenheim, Kathryn G, Reiger, Roman, Lam, Kit, Kurth, Mark J, Ansari, Aftab A, Coppel, Ross L, López-Hoyos, Marcos, Gershwin, M. Eric, Leung, Patrick S.C

“…Abstract Our laboratory has hypothesized that xenobiotic modification of the native lipoyl moiety of the major mitochondrial autoantigen, the E2 subunit of the…”
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Ongoing activation of autoantigen‐specific B cells in primary biliary cirrhosis by Zhang, Jun, Zhang, Weici, Leung, Patrick S.C., Bowlus, Christopher L., Dhaliwal, Sandeep, Coppel, Ross L., Ansari, Aftab A., Yang, Guo‐Xiang, Wang, Jinjun, Kenny, Thomas P., He, Xiao‐Song, Mackay, Ian R., Gershwin, M. Eric

“…The serologic hallmark of primary biliary cirrhosis (PBC), the antimitochondrial response to the E2 component of the pyruvate dehydrogenase complex (PDC‐E2),…”
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Shotgun proteomics: Identification of unique protein profiles of apoptotic bodies from biliary epithelial cells by Lleo, Ana, Zhang, Weici, McDonald, W. Hayes, Seeley, Erin H., Leung, Patrick S.C., Coppel, Ross L., Ansari, Aftab A., Adams, David H., Afford, Simon, Invernizzi, Pietro, Gershwin, M. Eric

“…Shotgun proteomics is a powerful analytic method to characterize complex protein mixtures in combination with multidimensional liquid chromatography‐tandem…”
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