Search Results - "Leung, S"

Is metformin still the most efficacious first‐line oral hypoglycaemic drug in treating type 2 diabetes? A network meta‐analysis of randomized controlled trials by Jia, Y., Lao, Y., Zhu, H., Li, N., Leung, S.‐W.

“…Summary Objectives The objective of the study is to compare the efficacy of hypoglycaemic drugs for type 2 diabetes mellitus (T2DM) by network meta‐analysis of…”
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Methyl Effects on Protein–Ligand Binding by Leung, Cheryl S, Leung, Siegfried S. F, Tirado-Rives, Julian, Jorgensen, William L

“…The effects of addition of a methyl group to a lead compound on biological activity are examined. A literature analysis of >2000 cases reveals that an activity…”
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Is Ocean Acidification Really a Threat to Marine Calcifiers? A Systematic Review and Meta‐Analysis of 980+ Studies Spanning Two Decades by Leung, Jonathan Y. S., Zhang, Sam, Connell, Sean D.

“…Ocean acidification is considered detrimental to marine calcifiers, but mounting contradictory evidence suggests a need to revisit this concept. This…”
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New Frontiers in Computer-Assisted Career Guidance Systems (CACGS): Implications From Career Construction Theory by Leung, S Alvin

“…This article addresses the use of computer-assisted career guidance systems (CACGS) in career interventions. Major CACGS developed in the past decades were…”
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A particulate-scale investigation of cemented sand behavior by Wang, Y.-H, Leung, S.-C

“…In this paper, triaxial tests and numerical simulations using the discrete element method (DEM) are combined to explore the underlying mechanisms of the unique…”
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Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series by Kommoss, S., McConechy, M.K., Kommoss, F., Leung, S., Bunz, A., Magrill, J., Britton, H., Kommoss, F., Grevenkamp, F., Karnezis, A., Yang, W., Lum, A., Krämer, B., Taran, F., Staebler, A., Lax, S., Brucker, S.Y., Huntsman, D.G., Gilks, C.B., McAlpine, J.N., Talhouk, A.

“…We have previously developed and confirmed a pragmatic molecular classifier for endometrial cancers; ProMisE (Proactive Molecular Risk Classifier for…”
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A clinically applicable molecular-based classification for endometrial cancers by Talhouk, A, McConechy, M K, Leung, S, Li-Chang, H H, Kwon, J S, Melnyk, N, Yang, W, Senz, J, Boyd, N, Karnezis, A N, Huntsman, D G, Gilks, C B, McAlpine, J N

“…Background: Classification of endometrial carcinomas (ECs) by morphologic features is inconsistent, and yields limited prognostic and predictive information. A…”
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Constraints on the chemical enrichment history of the Perseus Cluster of galaxies from high-resolution X-ray spectroscopy by Simionescu, A, Nakashima, S, Yamaguchi, H, Matsushita, K, Mernier, F, Werner, N, Tamura, T, Nomoto, K, de Plaa, J, Leung, S-C, Bamba, A, Bulbul, E, Eckart, M E, Ezoe, Y, Fabian, A C, Fukazawa, Y, Gu, L, Ichinohe, Y, Ishigaki, M N, Kaastra, J S, Kilbourne, C, Kitayama, T, Leutenegger, M, Loewenstein, M, Maeda, Y, Miller, E D, Mushotzky, R F, Noda, H, Pinto, C, Porter, F S, Safi-Harb, S, Sato, K, Takahashi, T, Ueda, S, Zha, S

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Endothelium‐dependent hyperpolarization: age, gender and blood pressure, do they matter? by Leung, S. W. S., Vanhoutte, P. M.

“…Under physiological conditions, the endothelium generates vasodilator signals [prostacyclin, nitric oxide NO and endothelium‐dependent hyperpolarization…”
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Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function by Ramezanpour, M, Schmidt, M L, Bodnariuc, I, Kulkarni, J A, Leung, S S W, Cullis, P R, Thewalt, J L, Tieleman, D P

“…Lipid nanoparticles (LNPs) composed of ionizable cationic lipids are currently the leading systems for siRNA delivery in liver disease, with the major…”
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Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study by Kendzerska, Tetyana, Gershon, Andrea S, Hawker, Gillian, Leung, Richard S, Tomlinson, George

“…Obstructive sleep apnea (OSA) has been reported to be a risk factor for cardiovascular (CV) disease. Although the apnea-hypopnea index (AHI) is the most…”
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Computational and experimental approaches for investigating nanoparticle-based drug delivery systems by Ramezanpour, M., Leung, S.S.W., Delgado-Magnero, K.H., Bashe, B.Y.M., Thewalt, J., Tieleman, D.P.

“…Most therapeutic agents suffer from poor solubility, rapid clearance from the blood stream, a lack of targeting, and often poor translocation ability across…”
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Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections by Leung, Sharon S. Y., Parumasivam, Thaigarajan, Gao, Fiona G., Carrigy, Nicholas B., Vehring, Reinhard, Finlay, Warren H., Morales, Sandra, Britton, Warwick J., Kutter, Elizabeth, Chan, Hak-Kim

“…Purpose The potential of aerosol phage therapy for treating lung infections has been demonstrated in animal models and clinical studies. This work compared the…”
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Three-dimensional models of core-collapse supernovae from low-mass progenitors with implications for Crab by Stockinger, G, Janka, H-T, Kresse, D, Melson, T, Ertl, T, Gabler, M, Gessner, A, Wongwathanarat, A, Tolstov, A, Leung, S-C, Nomoto, K, Heger, A

“…ABSTRACT We present 3D full-sphere supernova simulations of non-rotating low-mass (∼9 M⊙) progenitors, covering the entire evolution from core collapse through…”
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Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1 by Au Yeung, Chi Lam, Co, Ngai-Na, Tsuruga, Tetsushi, Yeung, Tsz-Lun, Kwan, Suet-Ying, Leung, Cecilia S., Li, Yong, Lu, Edward S., Kwan, Kenny, Wong, Kwong-Kwok, Schmandt, Rosemarie, Lu, Karen H., Mok, Samuel C.

“…Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum. However, the omental stromal cell-derived molecular determinants that…”
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Smart biosensors for multiplexed and fully integrated point-of-care diagnostics by Romeo, A, Leung, T S, Sánchez, S

“…Point-of-care diagnostics (PoC) and personalised medicine are highly valuable for the improvement of world health. Smartphone PoC platforms which precisely…”
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Consensus on precision medicine for metastatic cancers: a report from the MAP conference by Swanton, C., Soria, J.-C., Bardelli, A., Biankin, A., Caldas, C., Chandarlapaty, S., de Koning, L., Dive, C., Feunteun, J., Leung, S.-Y., Marais, R., Mardis, E.R., McGranahan, N., Middleton, G., Quezada, S.A., Rodón, J., Rosenfeld, N., Sotiriou, C., André, F.

“…Recent advances in biotechnologies have led to the development of multiplex genomic and proteomic analyses for clinical use. Nevertheless, guidelines are…”
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LAG-3+ tumor infiltrating lymphocytes in breast cancer: clinical correlates and association with PD-1/PD-L1+ tumors by Burugu, S., Gao, D., Leung, S., Chia, S.K., Nielsen, T.O.

“…Novel immune checkpoint blockade strategies are being evaluated in clinical trials and include targeting the lymphocyte activation gene 3 (LAG-3) checkpoint,…”
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Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020 by Wu, Peng, Hao, Xinxin, Lau, Eric H Y, Wong, Jessica Y, Leung, Kathy S M, Wu, Joseph T, Cowling, Benjamin J, Leung, Gabriel M

“…A novel coronavirus (2019-nCoV) causing severe acute respiratory disease emerged recently in Wuhan, China. Information on reported cases strongly indicates…”
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Overcoming Shellfish Allergy: How Far Have We Come? by Wai, Christine Y Y, Leung, Nicki Y H, Chu, Ka Hou, Leung, Patrick S C, Leung, Agnes S Y, Wong, Gary W K, Leung, Ting Fan

“…Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the…”
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