Search Results - "Leung, Rainbow Wing Hei"

Targeting AXL induces tumor-intrinsic immunogenic response in tyrosine kinase inhibitor-resistant liver cancer by Xie, Yunong, Wu, Haofeng, He, Yimiao, Liu, Linglin, Huang, Ianto Bosheng, Zhou, Lei, Lin, Cheuk-Yin, Leung, Rainbow Wing-Hei, Loh, Jia-Jian, Lee, Terence Kin-Wah, Ding, Jin, Man, Kwan, Ma, Stephanie, Tong, Man

“…Hepatocellular carcinoma (HCC) is an aggressive malignancy without effective therapeutic approaches. Here, we evaluate the tumor-intrinsic mechanisms that…”
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Wnt/β-Catenin Signaling as a Driver of Stemness and Metabolic Reprogramming in Hepatocellular Carcinoma by Leung, Rainbow Wing Hei, Lee, Terence Kin Wah

“…Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide due to its high rates of tumor recurrence and metastasis. Aberrant Wnt/β-catenin…”
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Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma by Leung, Carmen Oi Ning, Yang, Yang, Leung, Rainbow Wing Hei, So, Karl Kam Hei, Guo, Hai Jun, Lei, Martina Mang Leng, Muliawan, Gregory Kenneth, Gao, Yuan, Yu, Qian Qian, Yun, Jing Ping, Ma, Stephanie, Zhao, Qian, Lee, Terence Kin Wah

“…Increasing evidence has demonstrated that drug resistance can be acquired in cancer cells by kinase rewiring, which is an obstacle for efficient cancer…”
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Hampering Stromal Cells in the Tumor Microenvironment as a Therapeutic Strategy to Destem Cancer Stem Cells by Chung, Katherine Po Sin, Leung, Rainbow Wing Hei, Lee, Terence Kin Wah

“…Cancer stem cells (CSCs) within the tumor bulk play crucial roles in tumor initiation, recurrence and therapeutic resistance. In addition to intrinsic…”
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Identification of KCTD17 as a RAS stabilizer in hepatocellular carcinoma by Leung, Rainbow Wing Hei, Lee, Terence Kin Wah

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EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma by Leung, Hoi Wing, Leung, Carmen Oi Ning, Lau, Eunice Y, Chung, Katherine Po Sin, Mok, Etienne H, Lei, Martina Mang Leng, Leung, Rainbow Wing Hei, Tong, Man, Keng, Vincent W, Ma, Cong, Zhao, Qian, Ng, Irene Oi Lin, Ma, Stephanie, Lee, Terence K

“…The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer…”
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UBE2T: A new molecular regulator of cancer stemness in hepatocellular carcinoma by Leung, Rainbow Wing Hei, Ho, Nicole Pui Yu, Leung, Carmen Oi Ning, Lee, Terence Kin Wah

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Abstract 395: Resistance to tyrosine kinase inhibitor confers an immunosuppressive microenvironment and cross-resistance to immunotherapy through AXL/PDPK1 axis in liver cancer by Xie, Yunong, Huang, Bosheng, Yu, Huajian, Loh, Jia-Jian, Leung, Rainbow Wing-Hei, Lee, Terence, Ma, Stephanie, Tong, Man

“…Abstract Systemic therapy is the current standard of care for unresectable advanced hepatocellular carcinoma (HCC), the most malignant form of liver cancer…”
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SCYL3, as a novel binding partner and regulator of ROCK2, promotes hepatocellular carcinoma progression by Lei, Martina Mang Leng, Leung, Carmen Oi Ning, Lau, Eunice Yuen Ting, Leung, Rainbow Wing Hei, Ma, Victor Wan San, Tong, Man, Lu, Yin Ying, Huang, Chen Yang, Zhu, Qiao Hua, Ng, Irene Oi Lin, Ma, Stephanie, Lee, Terence Kin Wah

“…SCY1-like pseudokinase 3 (SCYL3) was identified as a binding partner of ezrin, implicating it in metastasis. However, the clinical relevance and functional…”
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