Search Results - "Leung, Preston"

Development of a machine learning model for early prediction of plasma leakage in suspected dengue patients by Zargari Marandi, Ramtin, Leung, Preston, Sigera, Chathurani, Murray, Daniel Dawson, Weeratunga, Praveen, Fernando, Deepika, Rodrigo, Chaturaka, Rajapakse, Senaka, MacPherson, Cameron Ross

“…At least a third of dengue patients develop plasma leakage with increased risk of life-threatening complications. Predicting plasma leakage using laboratory…”
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Associations of functional human leucocyte antigen class I groups with HIV viral load in a heterogeneous cohort by Zucco, Adrian G, Bennedbæk, Marc, Ekenberg, Christina, Gabrielaite, Migle, Leung, Preston, Polizzotto, Mark N, Kan, Virginia, Murray, Daniel D, Lundgren, Jens D, MacPherson, Cameron R

“…Human leucocyte antigen (HLA) class I alleles are the main host genetic factors involved in controlling HIV-1 viral load (VL). Nevertheless, HLA diversity has…”
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Adaptation of Oxford Nanopore technology for hepatitis C whole genome sequencing and identification of within-host viral variants by Riaz, Nasir, Leung, Preston, Barton, Kirston, Smith, Martin A, Carswell, Shaun, Bull, Rowena, Lloyd, Andrew R, Rodrigo, Chaturaka

“…Hepatitis C (HCV) and many other RNA viruses exist as rapidly mutating quasi-species populations in a single infected host. High throughput characterization of…”
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Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection by Cai, Curtis, Samir, Jerome, Pirozyan, Mehdi R., Adikari, Thiruni N., Gupta, Money, Leung, Preston, Hughes, Brendan, Van der Byl, Willem, Rizzetto, Simone, Elthala, Auda, Keoshkerian, Elizabeth, Palgen, Jean-Louis, Peters, Timothy, Nguyen, Thi H. O., Louie, Raymond, Kedzierska, Katherine, Gaudieri, Silvana, Bull, Rowena A., Lloyd, Andrew R., Luciani, Fabio

“…T cell exhaustion is a hallmark of hepatitis C virus (HCV) infection and limits protective immunity in chronic viral infections and cancer. Limited knowledge…”
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Conserved epitopes with high HLA-I population coverage are targets of CD8+ T cells associated with high IFN-γ responses against all dengue virus serotypes by Adikari, Thiruni N., Di Giallonardo, Francesca, Leung, Preston, Grifoni, Alba, Sette, Alex, Weiskopf, Daniela, Bull, Rowena A., Luciani, Fabio

“…Cytotoxic CD8 + T cells are key for immune protection against viral infections. The breadth and cross-reactivity of these responses are important against…”
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Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring by Youngson, Neil, Lecomte, Virginie, Maloney, Christopher, Leung, Preston, Liu, Jia, Hesson, Luke, Luciani, Fabio, Krause, Lutz, Morris, Margaret

“…There is now strong evidence that the paternal contribution to offspring phenotype at fertilisation is more than just DNA. However, the identity and mechanisms…”
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The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-naïve participants by Mørup, Sara Bohnstedt, Leung, Preston, Reilly, Cavan, Sherman, Brad T, Chang, Weizhong, Milojevic, Maja, Milinkovic, Ana, Liappis, Angelike, Borgwardt, Line, Petoumenos, Kathy, Paredes, Roger, Mistry, Shweta S, MacPherson, Cameron R, Lundgren, Jens, Helleberg, Marie, Reekie, Joanne, Murray, Daniel D

“…Human genetic contribution to HIV progression remains inadequately explained. The type 1 interferon (IFN) pathway is important for host control of HIV and…”
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Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort by Dos Santos, Quenia, Leung, Preston, Thorball, Christian W, Ledergerber, Bruno, Fellay, Jacques, MacPherson, Cameron R, Hornum, Mads, Terrones-Campos, Cynthia, Rasmussen, Allan, Gustafsson, Finn, Perch, Michael, Sørensen, Søren S, Ekenberg, Christina, Lundgren, Jens D, Feldt-Rasmussen, Bo, Reekie, Joanne

“…Type 2 diabetes mellitus (T2DM) can be multifactorial where both genetics and environmental factors play a role. We aimed to investigate the use of polygenic…”
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Evolution of within-host variants of the hepatitis C virus by Riaz, Nasir, Leung, Preston, Bull, Rowena A., Lloyd, Andrew R., Rodrigo, Chaturaka

“…Comprehensive investigation of the within-host evolution of hepatitis C virus (HCV) variants has been difficult without high coverage deep sequencing data and…”
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Association between TET2 genetic variation and viral load in people living with HIV by Murray, Daniel D., Grund, Birgit, MacPherson, Cameron, Ekenberg, Christina, Zucco, Adrian, Reekie, Joanne, Dominguez-Dominguez, Lourdes, Leung, Preston, Fusco, Dahlene, Gras, Julien, Gerstoft, Jan, Helleberg, Marie, Borges, Álvaro H., Polizzotto, Mark, Lundgren, Jens D.

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Association between ten-eleven methylcytosine dioxygenase 2 genetic variation and viral load in people with HIV by Murray, Daniel D., Grund, Birgit, MacPherson, Cameron R., Ekenberg, Christina, Zucco, Adrian G., Reekie, Joanne, Dominguez-Dominguez, Lourdes, Leung, Preston, Fusco, Dahlene, Gras, Julien, Gerstoft, Jan, Helleberg, Marie, Borges, Álvaro H., Polizzotto, Mark N., Lundgren, Jens D.

“…Identifying genetic factors that influence HIV-pathogenesis is critical for understanding disease pathways. Previous studies have suggested a role for the…”
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Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies by Walker, Melanie R., Leung, Preston, Eltahla, Auda A., Underwood, Alexander, Abayasingam, Arunasingam, Brasher, Nicholas A., Li, Hui, Wu, Bing-Ru, Maher, Lisa, Luciani, Fabio, Lloyd, Andrew R., Bull, Rowena A.

“…Hepatitis C virus (HCV) is one of very few viruses that are either naturally cleared, or alternatively persist to cause chronic disease. Viral diversity and…”
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Higher abundance of enterovirus A species in the gut of children with islet autoimmunity by Kim, Ki Wook, Horton, Jessica L., Pang, Chi Nam Ignatius, Jain, Komal, Leung, Preston, Isaacs, Sonia R., Bull, Rowena A., Luciani, Fabio, Wilkins, Marc R., Catteau, Jacki, Lipkin, W. Ian, Rawlinson, William D., Briese, Thomas, Craig, Maria E.

“…Enteroviruses (EVs) are prime candidate environmental triggers of islet autoimmunity (IA), with potential as vaccine targets for type 1 diabetes prevention…”
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Early Dysglycemia Is Detectable Using Continuous Glucose Monitoring in Very Young Children at Risk of Type 1 Diabetes by Haynes, Aveni, Tully, Alexandra, Smith, Grant J, Penno, Megan A S, Craig, Maria E, Wentworth, John M, Huynh, Tony, Colman, Peter G, Soldatos, Georgia, Anderson, Amanda J, McGorm, Kelly J, Oakey, Helena, Couper, Jennifer J, Davis, Elizabeth A

“…Continuous glucose monitoring (CGM) can detect early dysglycemia in older children and adults with presymptomatic type 1 diabetes (T1D) and predict risk of…”
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Single-Dose Vaccination with a Hepatotropic Adeno-associated Virus Efficiently Localizes T Cell Immunity in the Liver with the Potential To Confer Rapid Protection against Hepatitis C Virus by Mekonnen, Zelalem A, Grubor-Bauk, Branka, English, Kieran, Leung, Preston, Masavuli, Makutiro G, Shrestha, Ashish C, Bertolino, Patrick, Bowen, David G, Lloyd, Andrew R, Gowans, Eric J, Wijesundara, Danushka K

“…Hepatitis C virus (HCV) is a significant contributor to the global disease burden, and development of an effective vaccine is required to eliminate HCV…”
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Transmitted/Founder Viruses Rapidly Escape from CD8+ T Cell Responses in Acute Hepatitis C Virus Infection by Bull, Rowena A, Leung, Preston, Gaudieri, Silvana, Deshpande, Pooja, Cameron, Barbara, Walker, Melanie, Chopra, Abha, Lloyd, Andrew R, Luciani, Fabio

“…The interaction between hepatitis C virus (HCV) and cellular immune responses during very early infection is critical for disease outcome. To date, the impact…”
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1162. A data-driven approach to predict plasma leakage using explainable machine learning by Marandi, Ramtin Zargari, Leung, Preston, Sigera, Chathurani, Murray, Daniel Dawson, Weeratunga, Praveen, Fernando, Deepika, Rodrigo, Chaturaka, Rajapakse, Senaka, MacPherson, Cameron

“…Abstract Background Dengue could cause complications with an estimated 10,000 deaths per annum. It mostly affects low- and middle-income countries such as Sri…”
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Understanding the complex evolution of rapidly mutating viruses with deep sequencing: Beyond the analysis of viral diversity by Leung, Preston, Eltahla, Auda A., Lloyd, Andrew R., Bull, Rowena A., Luciani, Fabio

“…•Deep sequencing data provide unprecedented resolution in studying epidemics of rapidly mutating viruses in large population.•Next generation sequencing can…”
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Single molecule, near full-length genome sequencing of dengue virus by Adikari, Thiruni N., Riaz, Nasir, Sigera, Chathurani, Leung, Preston, Valencia, Braulio M., Barton, Kirston, Smith, Martin A., Bull, Rowena A., Li, Hui, Luciani, Fabio, Weeratunga, Praveen, Thein, Tun-Linn, Lim, Vanessa W. X., Leo, Yee-Sin, Rajapakse, Senaka, Fink, Katja, Lloyd, Andrew R., Fernando, Deepika, Rodrigo, Chaturaka

“…Current methods for dengue virus (DENV) genome amplification, amplify parts of the genome in at least 5 overlapping segments and then combine the output to…”
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A Bioinformatics Pipeline for the Analyses of Viral Escape Dynamics and Host Immune Responses during an Infection by Leung, Preston, Bull, Rowena, Lloyd, Andrew, Luciani, Fabio

“…Rapidly mutating viruses, such as hepatitis C virus (HCV) and HIV, have adopted evolutionary strategies that allow escape from the host immune response via…”
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