Search Results - "Leung, Peter C. K"

Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1 by Wang, Xiaoyan, Zhang, Xinyue, Dang, Yujie, Li, Duan, Lu, Gang, Chan, Wai-Yee, Leung, Peter C K, Zhao, Shidou, Qin, Yingying, Chen, Zi-Jiang

“…The genetic etiology of premature ovarian insufficiency (POI) has been well established to date, however, the role of long noncoding RNAs (lncRNAs) in POI is…”
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Fibroblast growth factor 2 induces E-cadherin down-regulation via PI3K/Akt/mTOR and MAPK/ERK signaling in ovarian cancer cells by Lau, Man-Tat, So, Wai-Kin, Leung, Peter C K

“…Fibroblast growth factor 2 (FGF2) is produced by ovarian cancer cells and it has been suggested to play an important role in tumor progression. In this study,…”
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Activin A, B, and AB Increase Human Trophoblast Cell Invasion by Up-regulating N-Cadherin by Li, Yan, Klausen, Christian, Cheng, Jung-Chien, Zhu, Hua, Leung, Peter C. K

“…Context: Inhibin β-subunits and activin receptors are expressed by human trophoblast cells. Although activin A has been shown to enhance human trophoblast cell…”
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BMP15 Suppresses Progesterone Production by Down-Regulating StAR via ALK3 in Human Granulosa Cells by Chang, Hsun-Ming, Cheng, Jung-Chien, Klausen, Christian, Leung, Peter C. K

“…In addition to somatic cell-derived growth factors, oocyte-derived growth differentiation factor (GDF)9 and bone morphogenetic protein (BMP)15 play essential…”
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Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia by DING, Guo-Lian, WANG, Fang-Fang, LEUNG, Peter C. K, SHENG, Jian-Zhong, HUANG, He-Feng, JING SHU, SHEN TIAN, YING JIANG, DAN ZHANG, NING WANG, QIONG LUO, YU ZHANG, FAN JIN

“…Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of diabetes in offspring. However, the mechanisms involved and the…”
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TGF-β1 Up-Regulates Connective Tissue Growth Factor Expression in Human Granulosa Cells through Smad and ERK1/2 Signaling Pathways by Cheng, Jung-Chien, Chang, Hsun-Ming, Fang, Lanlan, Sun, Ying-Pu, Leung, Peter C K

“…Connective tissue growth factor (CTGF), which is also called CCN2, is a secreted matricellular protein. CTGF regulates various important cellular functions by…”
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Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia by Liu, Mingxi, Niu, Yue, Ma, Kongyang, Leung, Peter C. K, Chen, Zi-Jiang, Wei, Daimin, Li, Yan

“…Abstract Background Preeclampsia (PE) is a leading cause of maternal and perinatal mortality and morbidity worldwide, but effective early prediction remains a…”
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A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells by Qu, Fan, Wang, Fang-Fang, Yin, Rong, Ding, Guo-Lian, El-prince, Mohamed, Gao, Qian, Shi, Bi-Wei, Pan, Hui-Hui, Huang, Yi-Ting, Jin, Min, Leung, Peter C. K., Sheng, Jian-Zhong, Huang, He-Feng

“…The objective of this study was to explore whether hyperandrogenism induces epigenetic alterations of peroxisome proliferator-activated receptor gamma 1…”
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Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells by Luo, Xiaoyan, Chang, Hsun-Ming, Yi, Yuyin, Sun, Yingpu, Leung, Peter C K

“…Bone morphogenetic protein 2 (BMP2), growth differentiation factor 8 (GDF8) and their functional receptors are expressed in human ovarian follicles, and these…”
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TGF-β1 Induces COX-2 Expression and PGE2 Production in Human Granulosa Cells Through Smad Signaling Pathways by Fang, Lanlan, Chang, Hsun-Ming, Cheng, Jung-Chien, Leung, Peter C. K, Sun, Ying-Pu

“…Context: Cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) production have been shown to play key roles in the regulation of ovulation. The TGF-β…”
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TGF-beta induces serous borderline ovarian tumor cell invasion by activating EMT but triggers apoptosis in low-grade serous ovarian carcinoma cells by Cheng, Jung-Chien, Auersperg, Nelly, Leung, Peter C K

“…Apoptosis in ovarian surface epithelial (OSE) cells is induced by transforming growth factor-beta (TGF-β). However, high-grade serous ovarian carcinomas (HGC)…”
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AP-1 Transcription Factors c-FOS and c-JUN Mediate GnRH-Induced Cadherin-11 Expression and Trophoblast Cell Invasion by Peng, Bo, Zhu, Hua, Ma, Liyang, Wang, Yan-ling, Klausen, Christian, Leung, Peter C. K

“…GnRH is expressed in first-trimester human placenta and increases cell invasion in extravillous cytotrophoblasts (EVTs). Invasive phenotypes have been reported…”
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EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells? by Cheng, Jung-Chien, Auersperg, Nelly, Leung, Peter C K

“…In high-grade ovarian cancer cultures, it has been shown that epidermal growth factor (EGF) induces cell invasion by activating an epithelial-mesenchymal…”
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EGF-like Growth Factors Induce COX-2–Derived PGE2 Production Through ERK1/2 in Human Granulosa Cells by Fang, Lanlan, Cheng, Jung-Chien, Chang, Hsun-Ming, Sun, Ying-Pu, Leung, Peter C. K

“…Context: Aberrant regulation of ovulation is one of the major causes of infertility. In animal models, 3 epidermal growth factor (EGF)-like growth factors,…”
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TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome by Fang, Lanlan, Li, Yiran, Wang, Sijia, Li, Yuxi, Chang, Hsun-Ming, Yi, Yuyin, Yan, Yang, Thakur, Avinash, Leung, Peter C. K., Cheng, Jung-Chien, Sun, Ying-Pu

“…Ovarian hyperstimulation syndrome (OHSS) is one of the most serious and iatrogenic complications that can occur during in vitro fertilization treatment…”
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The Human Gonadotropin-Inhibitory Hormone Ortholog RFamide-Related Peptide-3 Suppresses Gonadotropin-Induced Progesterone Production in Human Granulosa Cells by Oishi, Hajime, Klausen, Christian, Bentley, George E, Osugi, Tomohiro, Tsutsui, Kazuyoshi, Gilks, C. Blake, Yano, Tetsu, Leung, Peter C. K

“…RFamide-related peptide-3 (RFRP-3), a mammalian ortholog of avian gonadotropin-inhibitory hormone, has pronounced inhibitory effects on reproduction in a…”
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Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells by Chang, Hsun-Ming, Bai, Long, Zhu, Yi-Min, Leung, Peter C K

“…Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation. As a member of…”
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EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells by Li, Yuxi, Chang, Hsun-Ming, Zhu, Hua, Sun, Ying-Pu, Leung, Peter C K

“…The epidermal growth factor (EGF)-like factors, comprising amphiregulin (AREG), betacellulin (BTC), and epiregulin (EREG), play a critical role in regulating…”
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Expression of long noncoding RNAs in the ovarian granulosa cells of women with diminished ovarian reserve using high-throughput sequencing by Dong, Li, Xin, Xin, Chang, Hsun-Ming, Leung, Peter C. K, Yu, Chen, Lian, Fang, Wu, Haicui

“…Abstract Background Infertility is a global reproductive-health problem, and diminished ovarian reserve (DOR) is one of the common causes of female…”
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Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring by Lin, Xian-Hua, Gao, Ling, Tian, Shen, Klausen, Christian, Guo, Meng-Xi, Gao, Qian, Liu, Miao-E., Wang, Hui, Wu, Dan-Dan, Zhou, Cheng-Liang, Yang, Jing, Meng, Ye, Liu, Ye, Xu, Gu-Feng, Tan, Ya-Jing, Ullah, Kamran, Zhu, Yi-Min, Fraser, William D., Sheng, Jian-Zhong, Leung, Peter C. K., Muglia, Louis J., Wu, Yan-Ting, Huang, He-Feng

“…Maternal metabolism dysregulation during pregnancy predisposes offspring to major diseases, including hypertension, in later life, but the mechanism involved…”
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