Search Results - "Leung, P S"

Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin–angiotensin system in mice by Cheng, Q., Boucher, B. J., Leung, P. S.

“…Aims/hypothesis Vitamin D is necessary for normal insulin action and suppresses renin production. Increased renin–angiotensin system (RAS) activity causes…”
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Inhibition of the sodium glucose co-transporter-2: its beneficial action and potential combination therapy for type 2 diabetes mellitus by Chen, L. H., Leung, P. S.

“…Sodium glucose co‐transporter‐2 (SGLT2) inhibitors are an emerging class of glucose‐lowering drugs in the management of type 2 diabetes mellitus (T2DM). In…”
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Generic maximum power point tracking controller for small-scale wind turbines by Narayana, M., Putrus, G.A., Jovanovic, M., Leung, P.S., McDonald, S.

“…The output power of a wind energy conversion system (WECS) is maximized if the wind rotor is driven at an optimal rotational speed for a particular wind speed…”
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Pathogen infections and primary biliary cholangitis by Tanaka, A., Leung, P. S. C., Gershwin, M. E.

“…Summary Primary biliary cholangitis (PBC) is a multi‐factorial disease caused by the interaction of both genetic predisposition and environmental triggers…”
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Calcitriol Reduces Hepatic Triglyceride Accumulation and Glucose Output Through Ca2+/CaMKKβ/AMPK Activation Under Insulin-Resistant Conditions in Type 2 Diabetes Mellitus by Cheng, S, So, W Y, Zhang, D, Cheng, Q, Boucher, B J, Leung, P S

“…The present study was designed to investigate the effects of calcitriol (the active hormonal metabolite of vitamin D) on hepatic metabolic abnormalities in…”
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A novel method for manufacturing sintered aluminium heat pipes (SAHP) by Ameli, M., Agnew, B., Leung, P.S., Ng, B., Sutcliffe, C.J., Singh, J., McGlen, R.

“…This work is the product of an ongoing research project in the Faculty of Engineering and Environment of Northumbria University in collaboration with…”
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A novel role for vitamin D: modulation of expression and function of the local renin–angiotensin system in mouse pancreatic islets by Cheng, Q., Li, Y. C., Boucher, B. J., Leung, P. S.

“…Aims/hypothesis The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system…”
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Effects of combining linagliptin treatment with BI-38335, a novel SGLT2 inhibitor, on pancreatic islet function and inflammation in db/db mice by Chen, L, Klein, T, Leung, P S

“…Dipeptidyl peptidase-4 (DPP-4) inhibitors enhance incretin actions and beta-cell function. Concurrently, sodium-glucose co-transporter 2 (SGLT2) inhibitors…”
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Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice by So, W Y, Cheng, Q, Xu, A, Lam, K S L, Leung, P S

“…Fibroblast growth factor (FGF) 21 is an endocrine factor that normalizes glucose homeostasis and reduces insulin resistance in diabetes. Although the pancreas…”
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Yes-Associated Protein 1 Exhibits Oncogenic Property in Gastric Cancer and Its Nuclear Accumulation Associates with Poor Prognosis by WEI KANG, TONG, Joanna H. M, SUNG, Joseph J. Y, TO, Ka-Fai, CHAN, Anthony W. H, LEE, Tin-Lap, LUNG, Raymond W. M, LEUNG, Patrick P. S, SO, Ken K. Y, KAICHUN WU, DAIMING FAN, JUN YU

“…Yes-associated protein 1 (YAP1) is a multifunctional protein that can interact with different transcription factors to activate gene expression. The role of…”
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Identification of a novel bat papillomavirus by metagenomics by Tse, Herman, Tsang, Alan K L, Tsoi, Hoi-Wah, Leung, Andy S P, Ho, Chi-Chun, Lau, Susanna K P, Woo, Patrick C Y, Yuen, Kwok-Yung

“…The discovery of novel viruses in animals expands our knowledge of viral diversity and potentially emerging zoonoses. High-throughput sequencing (HTS)…”
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Validation of various windmill brake state models used by blade element momentum calculation by Pratumnopharat, P., Leung, P.S.

“…The concept of windmill brake state model is considered in this paper. Blade Element Momentum (BEM) calculation often calculates the value of thrust…”
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Seven Quassinoids from Fructus Bruceae with Cytotoxic Effects on Pancreatic Adenocarcinoma Cell Lines by Zhao, M., Lau, S. T., Leung, P. S., Che, C. T., Lin, Z. X.

“…Our previous studies showed that the alcohol extract of the fruit of Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic…”
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Mechanisms of protective effects induced by blockade of the renin-angiotensin system: novel role of the pancreatic islet angiotensin-generating system in Type 2 diabetes by Leung, P. S.

“…Large clinical trials have shown that inhibition of the renin–angiotensin system (RAS) can delay and/or prevent the onset of Type 2 diabetes mellitus (T2DM) in…”
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Current progress in stem cell research and its potential for islet cell transplantation by Leung, P S, Ng, K Y

“…Diabetes is characterized by insulin deficiency concomitant with hyperglycemia due to reduced islet cell mass and/or dysfunction. Currently, insulin…”
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Long-term oxidation of newly developed HIPIMS and PVD coatings with neural network prediction modelling by Danaher, S., Dudziak, T., Datta, P.K., Hasan, R., Leung, P.S.

“…► TiAlYN/CrN+Al2O3 had a better oxidation resistance than the TiAlCr coating. ► Interlayer thermal expansion mismatch is paramount in oxidation behaviour. ►…”
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Endogenous interleukin‐22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice by Yang, G.‐X., Sun, Y., Tsuneyama, K., Zhang, W., Leung, P. S. C., He, X.‐S., Ansari, A. A., Bowlus, C., Ridgway, W. M., Gershwin, M. E.

“…Summary During chronic inflammation, interleukin (IL)‐22 expression is up‐regulated in both CD4 and CD8 T cells, exerting a protective role in infections…”
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Review article: pancreatic renin–angiotensin systems in health and disease by Skipworth, J. R. A., Szabadkai, G., Olde Damink, S. W. M., Leung, P. S., Humphries, S. E., Montgomery, H. E.

“…Aliment Pharmacol Ther 2011; 34: 840–852 Summary Background  In addition to the circulating (endocrine) renin–angiotensin system (RAS), local renin–angiotensin…”
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Role of the RAS in pancreatic cancer by Lau, Sin Ting, Leung, Po Sing

“…Angiotensin II (Ang II), a main effector peptide of the renin-angiotensin system (RAS), mediates a hormonal action in the maintenance of blood pressure and…”
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The multi‐hit hypothesis of primary biliary cirrhosis: polyinosinic‐polycytidylic acid (poly I:C) and murine autoimmune cholangitis by Ambrosini, Y. M., Yang, G.‐X., Zhang, W., Tsuda, M., Shu, S., Tsuneyama, K., Leung, P. S. C., Ansari, A. A., Coppel, R. L., Gershwin, M. E.

“…Summary A void in understanding primary biliary cirrhosis (PBC) is the absence of appropriate animal models. Our laboratory has studied a murine model of…”
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