Search Results - "Leung, Miguel Ricardo"

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    A dynamic basal complex modulates mammalian sperm movement by Khanal, Sushil, Leung, Miguel Ricardo, Royfman, Abigail, Fishman, Emily L., Saltzman, Barbara, Bloomfield-Gadêlha, Hermes, Zeev-Ben-Mordehai, Tzviya, Avidor-Reiss, Tomer

    Published in Nature communications (21-06-2021)
    “…Reproductive success depends on efficient sperm movement driven by axonemal dynein-mediated microtubule sliding. Models predict sliding at the base of the tail…”
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    Journal Article
  3. 3

    The multi‐scale architecture of mammalian sperm flagella and implications for ciliary motility by Leung, Miguel Ricardo, Roelofs, Marc C, Ravi, Ravi Teja, Maitan, Paula, Henning, Heiko, Zhang, Min, Bromfield, Elizabeth G, Howes, Stuart C, Gadella, Bart M, Bloomfield‐Gadêlha, Hermes, Zeev‐Ben‐Mordehai, Tzviya

    Published in The EMBO journal (01-04-2021)
    “…Motile cilia are molecular machines used by a myriad of eukaryotic cells to swim through fluid environments. However, available molecular structures represent…”
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    Journal Article
  4. 4

    Looking back and looking forward: contributions of electron microscopy to the structural cell biology of gametes and fertilization by Ravi, Ravi Teja, Leung, Miguel Ricardo, Zeev-Ben-Mordehai, Tzviya

    Published in Open biology (01-09-2020)
    “…Mammalian gametes-the sperm and the egg-represent opposite extremes of cellular organization and scale. Studying the ultrastructure of gametes is crucial to…”
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    Journal Article
  5. 5

    Membrane Remodeling and Matrix Dispersal Intermediates During Mammalian Acrosomal Exocytosis by Leung, Miguel Ricardo, Ravi, Ravi Teja, Gadella, Bart M, Zeev-Ben-Mordehai, Tzviya

    “…To become fertilization-competent, mammalian sperm must undergo a complex series of biochemical and morphological changes in the female reproductive tract…”
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    Journal Article
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    A convolutional autoencoder approach for mining features in cellular electron cryo-tomograms and weakly supervised coarse segmentation by Zeng, Xiangrui, Leung, Miguel Ricardo, Zeev-Ben-Mordehai, Tzviya, Xu, Min

    Published in Journal of structural biology (01-05-2018)
    “…Cellular electron cryo-tomography enables the 3D visualization of cellular organization in the near-native state and at submolecular resolution. However, the…”
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    Journal Article
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    Cryo‐electron microscopy of cholinesterases, present and future by Leung, Miguel Ricardo, Zeev‐Ben‐Mordehai, Tzviya

    Published in Journal of neurochemistry (01-09-2021)
    “…Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) exist in a variety of oligomeric forms, each with defined cellular and subcellular distributions…”
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    Journal Article
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    Structural specializations of the sperm tail by Leung, Miguel Ricardo, Zeng, Jianwei, Wang, Xiangli, Roelofs, Marc C., Huang, Wei, Zenezini Chiozzi, Riccardo, Hevler, Johannes F., Heck, Albert J.R., Dutcher, Susan K., Brown, Alan, Zhang, Rui, Zeev-Ben-Mordehai, Tzviya

    Published in Cell (22-06-2023)
    “…Sperm motility is crucial to reproductive success in sexually reproducing organisms. Impaired sperm movement causes male infertility, which is increasing…”
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    Journal Article
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    Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly by Leung, Miguel Ricardo, van Bezouwen, Laura S., Schopfer, Lawrence M., Sussman, Joel L., Silman, Israel, Lockridge, Oksana, Zeev-Ben-Mordehai, Tzviya

    “…The quaternary structures of the cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), are essential for their localization and…”
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    Journal Article
  12. 12

    Structural Cell Biology of Mammalian Sperm by Leung, Miguel Ricardo Rilloraza

    Published 01-01-2020
    “…Reflecting the sheer diversity of reproductive modes and fertilization arenas, sperm are among the most structurally specialized and structurally diverse…”
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    Dissertation
  13. 13

    A convolutional autoencoder approach for mining features in cellular electron cryo-tomograms and weakly supervised coarse segmentation by Zeng, Xiangrui, Leung, Miguel Ricardo, Zeev-Ben-Mordehai, Tzviya, Xu, Min

    Published 28-12-2017
    “…Cellular electron cryo-tomography enables the 3D visualization of cellular organization in the near-native state and at submolecular resolution. However, the…”
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    Journal Article