Search Results - "Leung, Miguel Ricardo"
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In-cell structures of conserved supramolecular protein arrays at the mitochondria–cytoskeleton interface in mammalian sperm
Published in Proceedings of the National Academy of Sciences - PNAS (09-11-2021)“…Mitochondria–cytoskeleton interactions modulate cellular physiology by regulating mitochondrial transport, positioning, and immobilization. However, there is…”
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2
A dynamic basal complex modulates mammalian sperm movement
Published in Nature communications (21-06-2021)“…Reproductive success depends on efficient sperm movement driven by axonemal dynein-mediated microtubule sliding. Models predict sliding at the base of the tail…”
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3
The multi‐scale architecture of mammalian sperm flagella and implications for ciliary motility
Published in The EMBO journal (01-04-2021)“…Motile cilia are molecular machines used by a myriad of eukaryotic cells to swim through fluid environments. However, available molecular structures represent…”
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4
Looking back and looking forward: contributions of electron microscopy to the structural cell biology of gametes and fertilization
Published in Open biology (01-09-2020)“…Mammalian gametes-the sperm and the egg-represent opposite extremes of cellular organization and scale. Studying the ultrastructure of gametes is crucial to…”
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Membrane Remodeling and Matrix Dispersal Intermediates During Mammalian Acrosomal Exocytosis
Published in Frontiers in cell and developmental biology (10-12-2021)“…To become fertilization-competent, mammalian sperm must undergo a complex series of biochemical and morphological changes in the female reproductive tract…”
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6
Bicarbonate-Stimulated Membrane Reorganization in Stallion Spermatozoa
Published in Frontiers in cell and developmental biology (17-11-2021)“…Classical in vitro fertilization (IVF) is still poorly successful in horses. This lack of success is thought to be due primarily to inadequate capacitation of…”
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A convolutional autoencoder approach for mining features in cellular electron cryo-tomograms and weakly supervised coarse segmentation
Published in Journal of structural biology (01-05-2018)“…Cellular electron cryo-tomography enables the 3D visualization of cellular organization in the near-native state and at submolecular resolution. However, the…”
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8
Cryo‐electron microscopy of cholinesterases, present and future
Published in Journal of neurochemistry (01-09-2021)“…Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) exist in a variety of oligomeric forms, each with defined cellular and subcellular distributions…”
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Structural specializations of the sperm tail
Published in Cell (22-06-2023)“…Sperm motility is crucial to reproductive success in sexually reproducing organisms. Impaired sperm movement causes male infertility, which is increasing…”
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10
The remarkable sperm mitochondrial sheath: insights from cryo-electron tomography
Published in Biophysical journal (11-02-2022)Get full text
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Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly
Published in Proceedings of the National Academy of Sciences - PNAS (26-12-2018)“…The quaternary structures of the cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), are essential for their localization and…”
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Structural Cell Biology of Mammalian Sperm
Published 01-01-2020“…Reflecting the sheer diversity of reproductive modes and fertilization arenas, sperm are among the most structurally specialized and structurally diverse…”
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Dissertation -
13
A convolutional autoencoder approach for mining features in cellular electron cryo-tomograms and weakly supervised coarse segmentation
Published 28-12-2017“…Cellular electron cryo-tomography enables the 3D visualization of cellular organization in the near-native state and at submolecular resolution. However, the…”
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Journal Article