Search Results - "Leung, Keith K. H"

Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia by Wang, Cheng, Tan, Zhijia, Niu, Ben, Tsang, Kwok Yeung, Tai, Andrew, Chan, Wilson C W, Lo, Rebecca L K, Leung, Keith K H, Dung, Nelson W F, Itoh, Nobuyuki, Zhang, Michael Q, Chan, Danny, Cheah, Kathryn Song Eng

“…The integrated stress response (ISR) is activated by diverse forms of cellular stress, including endoplasmic reticulum (ER) stress, and is associated with…”
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Sox2 is required for sensory organ development in the mammalian inner ear by Cheah, Kathryn S. E, Kiernan, Amy E, Pelling, Anna L, Leung, Keith K. H, Tang, Anna S. P, Bell, Donald M, Tease, Charles, Lovell-Badge, Robin, Steel, Karen P

“…Sensory hair cells and their associated non-sensory supporting cells in the inner ear are fundamental for hearing and balance. They arise from a common…”
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SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression by Leung, Victor Y L, Gao, Bo, Leung, Keith K H, Melhado, Ian G, Wynn, Sarah L, Au, Tiffany Y K, Dung, Nelson W F, Lau, James Y B, Mak, Angel C Y, Chan, Danny, Cheah, Kathryn S E

“…Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic…”
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Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells by Cheung, Martin, Chan, Danny, Sham, Mai Har, Leung, Keith K. H., Liu, Jessica Aijia, Wang, Yinxiang, Cheah, Kathryn S. E.

“…Previous studies have demonstrated the ability of reprogramming endochondral bone into induced pluripotent stem (iPS) cells, but whether similar phenomenon…”
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SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms by Szeto, Irene Y Y, Chu, Daniel K H, Chen, Peikai, Chu, Ka Chi, Au, Tiffany Y K, Leung, Keith K H, Huang, Yong-Heng, Wynn, Sarah L, Mak, Angel C Y, Chan, Ying-Shing, Chan, Wood Yee, Jauch, Ralf, Fritzsch, Bernd, Sham, Mai Har, Lovell-Badge, Robin, Cheah, Kathryn S E

“…The in vivo mechanisms underlying dominant syndromes caused by mutations in SRY-Box Transcription Factor 9 ( ) and ( ) transcription factors, when they either…”
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Utility of HoxB2 enhancer-mediated Cre activity for functional studies in the developing inner ear by Szeto, Irene Y.Y., Leung, Keith K.H., Sham, Mai Har, Cheah, Kathryn S.E.

“…The rhombomere 4(r4)‐restricted expression of the mouse Hoxb2 gene is regulated by a 1.4‐kb enhancer‐containing fragment. Here, we showthat transgenic mouse…”
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Different cis-Regulatory DNA Elements Mediate Developmental Stage- and Tissue-Specific Expression of the Human COL2A1 Gene in Transgenic Mice by Keith K. H. Leung, Ng, Ling Jim, Ken K. Y. Ho, Patrick P. L. Tam, Kathryn S. E. Cheah

“…Expression of the type II collagen gene (human COL2A1, mouse Col2a1) heralds the differentiation of chondrocytes. It is also expressed in progenitor cells of…”
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Circling, Deafness, and Yellow Coat Displayed by Yellow Submarine (Ysb) and Light Coat and Circling (Lcc) Mice with Mutations on Chromosome 3 by Dong, Shuo, Leung, Keith K.H., Pelling, Anna L., Lee, Patrick Y.T., Tang, Anna S.P., Heng, Henry H.Q., Tsui, Lap C., Tease, Charles, Fisher, Graham, Steel, Karen P., Cheah, Kathryn S.E.

“…We describe here two mouse mutants, yellow submarine (Ysb) and light coat and circling (Lcc). Ysb arose as the result of insertions of a transgene, pAA2, into…”
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SOX9 Governs Differentiation Stage-Specific Gene Expression in Growth Plate Chondrocytes via Direct Concomitant Transactivation and Repression: e1002356 by Leung, Victor YL, Gao, Bo, Leung, Keith KH, Melhado, Ian G, Wynn, Sarah L, Au, Tiffany YK, Dung, Nelson WF, Lau, James YB, Mak, Angel CY, Chan, Danny, Cheah, Kathryn SE

“…Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic…”
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Human COL2A1-Directed SV40 T Antigen Expression in Transgenic and Chimeric Mice Results in Abnormal Skeletal Development by Kathryn S. E. Cheah, Levy, Alison, Trainor, Paul A., Albert W. K. Wai, Kuffner, Tamara, So, Chi Leung, Keith K. H. Leung, Lovell-Badge, Robin H., Patrick P. L. Tam

“…The ability of SV40 T antigen to cause abnormalities in cartilage development in transgenic mice and chimeras has been tested. The cis-regulatory elements of…”
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