Search Results - "Leung, Justin W.C."

Modularized Functions of the Fanconi Anemia Core Complex by Huang, Yaling, Leung, Justin W.C., Lowery, Megan, Matsushita, Nobuko, Wang, Yucai, Shen, Xi, Huong, Do, Takata, Minoru, Chen, Junjie, Li, Lei

“…The Fanconi anemia (FA) core complex provides the essential E3 ligase function for spatially defined FANCD2 ubiquitination and FA pathway activation. Of the…”
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Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion by Leung, Justin W.C, Chung, Stephen S.M, Chung, Sookja K

“…Abstract Endothelin-1 (ET-1) is up-regulated in the endothelial cells and astrocytes under ischemia. Transgenic mice with astrocytic ET-1 over-expression…”
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Modularized Functions of the Fanconi Anemia Core Complex by Huang, Yaling, Leung, Justin W.C., Lowery, Megan, Matsushita, Nobuko, Wang, Yucai, Shen, Xi, Huong, Do, Takata, Minoru, Chen, Junjie, Li, Lei

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ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair by Leung, Justin W C, Makharashvili, Nodar, Agarwal, Poonam, Chiu, Li-Ya, Pourpre, Renaud, Cammarata, Michael B, Cannon, Joe R, Sherker, Alana, Durocher, Daniel, Brodbelt, Jennifer S, Paull, Tanya T, Miller, Kyle M

“…Chromatin connects DNA damage response factors to sites of damaged DNA to promote the signaling and repair of DNA lesions. The histone H2A variants H2AX, H2AZ,…”
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CRISPR/Cas9 Gene Editing of Human Histone H2A Variant H2AX and MacroH2A by Leung, Justin W C, Emery, Lara E, Miller, Kyle M

“…Histone H2A variants play important roles in maintaining the integrity of the genome. For example, the histone variant H2AX is phosphorylated on Ser139 (called…”
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Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose by Sadhukhan, Ratan, Leung, Justin W. C., Garg, Sarthak, Krager, Kimberly J., Savenka, Alena V., Basnakian, Alexei G., Pathak, Rupak

“…Kruppel-like factor 2 (KLF2) is a positive transcriptional regulator of several endothelial protective molecules, including thrombomodulin (TM), a surface…”
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5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties by Huen, Michael S.Y, Leung, Justin W.C, Ng, Wah, Lui, W.S, Chan, Michelle N.S, Tze-Fei Wong, J, Xue, Hong

“…As part of an effort to identify naturally occurring GABA A receptor benzodiazepine binding site (BDS) ligands from traditional medicinal herbs, we previously…”
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UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair by Lee, Seong-Ok, Kelliher, Jessica L., Song, Wan, Tengler, Kyle, Sarkar, Aradhan, Dray, Eloise, Leung, Justin W.C.

“…The ubiquitin signaling pathway is crucial for the DNA damage response pathway. More specifically, RNF168 is integral in regulating DNA repair proteins at…”
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Enhancing scanning electrochemical microscopy's potential to probe dynamic co-culture systems via hyperspectral assisted-imaging by Goines, Sondrica, Deng, Mingchu, Glasscott, Matthew W, Leung, Justin W C, Dick, Jeffrey E

“…Precise determination of boundaries in co-culture systems is difficult to achieve with scanning electrochemical microscopy alone. Thus, biological scanning…”
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ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination by Lee, Doohyung, Apelt, Katja, Lee, Seong-Ok, Chan, Hsin-Ru, Luijsterburg, Martijn S, Leung, Justin W C, Miller, Kyle M

“…Abstract An inability to repair DNA double-strand breaks (DSBs) threatens genome integrity and can contribute to human diseases, including cancer. Mammalian…”
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LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation by West, Kirk L, Kelliher, Jessica L, Xu, Zhanzhan, An, Liwei, Reed, Megan R, Eoff, Robert L, Wang, Jiadong, Huen, Michael S Y, Leung, Justin W C

“…Abstract The tumor suppressor protein 53BP1 plays key roles in response to DNA double-strand breaks (DSBs) by serving as a master scaffold at the damaged…”
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Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin by Dong, Chao, West, Kirk L., Tan, Xin Yi, Li, Junshi, Ishibashi, Toyotaka, Yu, Cheng-han, Sy, Shirley M. H., Leung, Justin W. C., Huen, Michael S. Y.

“…DNA double-strand breaks (DSBs) trigger transient pausing of nearby transcription, an emerging ATM-dependent response that suppresses chromosomal instability…”
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Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination by Kelliher, Jessica L., West, Kirk L., Gong, Qingguo, Leung, Justin W. C.

“…Histone ubiquitination plays an important role in the DNA damage response (DDR) pathway. RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15)…”
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Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs by Ketkar, Amit, Smith, Lane, Johnson, Callie, Richey, Alyssa, Berry, Makayla, Hartman, Jessica H, Maddukuri, Leena, Reed, Megan R, Gunderson, Julie E C, Leung, Justin W C, Eoff, Robert L

“…Abstract We previously reported that human Rev1 (hRev1) bound to a parallel-stranded G-quadruplex (G4) from the c-MYC promoter with high affinity. We have…”
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Sae2/CtIP prevents R-loop accumulation in eukaryotic cells by Makharashvili, Nodar, Arora, Sucheta, Yin, Yizhi, Fu, Qiong, Wen, Xuemei, Lee, Ji-Hoon, Kao, Chung-Hsuan, Leung, Justin Wc, Miller, Kyle M, Paull, Tanya T

“…The Sae2/CtIP protein is required for efficient processing of DNA double-strand breaks that initiate homologous recombination in eukaryotic cells. Sae2/CtIP is…”
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Regulation of Chromatin Architecture by the PWWP Domain-Containing DNA Damage-Responsive Factor EXPAND1/MUM1 by Huen, Michael S.Y., Huang, Jun, Leung, Justin W.C., Sy, Shirley M.-H., Leung, Ka Man, Ching, Yick-Pang, Tsao, Sai Wah, Chen, Junjie

“…Dynamic changes of chromatin structure facilitate diverse biological events, including DNA replication, repair, recombination, and gene transcription. Recent…”
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A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation by Richards, Mark W., Leung, Justin W.C., Roe, S. Mark, Li, Kaiyi, Chen, Junjie, Bayliss, Richard

“…Mcph1 is mutated in autosomal recessive primary microcephaly and premature chromosome condensation (PCC) syndrome. Increased chromosome condensation is a…”
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Regulation of chromatin architecture by the PWWP domain-containing DNA damage responsive factor EXPAND1 by Huen, Michael S.Y., Huang, Jun, Leung, Justin W.C., Leung, Ka Man, Ching, Yick-Pang, Tsao, Sai Wah, Chen, Junjie

“…Dynamic changes of chromatin structure facilitate diverse biological events, including DNA replication, repair, recombination, and gene transcription. Recent…”
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Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina by Cheung, Simon S F, Leung, Justin W C, Lam, Amy K M, Lam, Karen S L, Chung, Stephen S M, Lo, Amy C Y, Chung, Sookja K

“…The level of endothelin-1 (ET-1), a potent vasoconstrictor, was associated with retinopathy under ischemia. The effects of endothelial endothelin-1 (ET-1)…”
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Naturally occurring 2′-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands by Huen, Michael S.Y., Hui, Kwok-Min, Leung, Justin W.C., Sigel, Erwin, Baur, Roland, Wong, J.Tze-Fei, Xue, Hong

“…Screening of traditional medicines has proven invaluable to drug development and discovery. Utilizing activity-guided purification, we previously reported the…”
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