Search Results - "Leung, Joseph C.K."

Kidney injury molecule-1: More than just an injury marker of tubular epithelial cells? by Lim, Ai Ing, Tang, Sydney C.W., Lai, Kar Neng, Leung, Joseph C.K.

“…Regardless of the original causes and etiology, the progression to renal function declines follows a final common pathway associated with tubulointerstitial…”
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The PAR-1 antagonist vorapaxar ameliorates kidney injury and tubulointerstitial fibrosis by Lok, Sarah W Y, Yiu, Wai Han, Li, Hongyu, Xue, Rui, Zou, Yixin, Li, Bin, Chan, Kam Wa, Chan, Loretta Y Y, Leung, Joseph C K, Lai, Kar Neng, Tang, Sydney C W

“…Protease-activated receptor (PAR)-1 has emerged as a key profibrotic player in various organs including kidney. PAR-1 activation leads to deposition of…”
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Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells by Lim, Ai Ing, Chan, Loretta Y.Y., Lai, Kar Neng, Tang, Sydney C.W., Chow, Chui Wa, Lam, Man Fai, Leung, Joseph C.K.

“…Tubulointerstitial injury is a common pathway in progressive renal impairment and human proximal tubular epithelial cells (PTEC) play a crucial role in this…”
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Recent advances in the understanding and management of IgA nephropathy by Lai, Kar Neng, Leung, Joseph C K, Tang, Sydney C W

“…Since its first description in 1968, IgA nephropathy has remained the most common form of primary glomerulonephritis leading to chronic kidney disease in…”
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Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy by MIAO LIN, WAI HAN YIU, HAO JIA WU, CHAN, Loretta Y. Y, LEUNG, Joseph C. K, WO SHING AU, KWOK WAH CHAN, KAR NENG LAI, TANG, Sydney C. W

“…Inflammation contributes to the tubulointerstitial lesions of diabetic nephropathy. Toll-like receptors (TLRs) modulate immune responses and inflammatory…”
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MEDIATORS OF INFLAMMATION AND FIBROSIS by Lai, Kar Neng, Tang, Sydney C.W, Leung, Joseph C.K

“…Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, PR China Correspondence to: K.N. Lai,…”
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Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress by Yiu, Wai Han, Wong, Dickson W L, Wu, Hao Jia, Li, Rui Xi, Yam, Irene, Chan, Loretta Y Y, Leung, Joseph C K, Lan, Hui Yao, Lai, Kar Neng, Tang, Sydney C W

“…Kallistatin is a serine protease inhibitor with anti-inflammatory, anti-angiogenic, and anti-oxidative properties. Since oxidative stress plays a critical role…”
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Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy by Leung, Joseph C.K., Lai, Kar Neng, Tang, Sydney C.W.

“…IgA nephropathy (IgAN), a common primary glomerulonephritis worldwide, is associated with a substantial risk of progression to end-stage renal failure. The…”
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The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy by Lin, Miao, Yiu, Wai Han, Li, Rui Xi, Wu, Hao Jia, Wong, Dickson W L, Chan, Loretta Y Y, Leung, Joseph C K, Lai, Kar Neng, Tang, Sydney C W

“…We recently showed that Toll-like receptor (TLR) TLR4 was overexpressed in the human diabetic kidney, which could promote tubular inflammation. Here we…”
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Protective role of kallistatin in renal fibrosis via modulation of Wnt/β-catenin signaling by Yiu, Wai Han, Li, Ye, Lok, Sarah W Y, Chan, Kam Wa, Chan, Loretta Y Y, Leung, Joseph C K, Lai, Kar Neng, Tsu, James H L, Chao, Julie, Huang, Xiao-Ru, Lan, Hui Yao, Tang, Sydney C W

“…Kallistatin is a multiple functional serine protease inhibitor that protects against vascular injury, organ damage and tumor progression. Kallistatin treatment…”
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Long-term study of mycophenolate mofetil treatment in IgA nephropathy by Tang, Sydney C.W., Tang, Anthony W.C., Wong, Sunny S.H., Leung, Joseph C.K., Ho, Yiu Wing, Lai, Kar Neng

“…Since the efficacy of mycophenolate mofetil (MMF) to treat immunoglobulin A (IgA) nephropathy is controversial, we extended our original study by following 40…”
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Inflammation in peritoneal dialysis by Lai, Kar Neng, Leung, Joseph C K

“…During peritoneal dialysis, peritoneal cells are repeatedly exposed to a non-physiological hypertonic environment with high glucose content and low pH. Current…”
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Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy by Tang, Sydney, Leung, Joseph C.K., Chan, Loretta Y.Y., Lui, Yun Hoi, Tang, Colin S.O., Kan, Chi Hang, Ho, Yiu Wing, Lai, Kar Neng

“…Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy. Mycophenolate mofetil (MMF) is increasingly used to treat primary glomerulopathies…”
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Tubule-specific deletion of LincRNA-p21ameliorates lipotoxic kidney injury by Li, Bin, Leung, Joseph C K, Chan, Loretta Y Y, Li, Hong-Yu, Yiu, Wai-Han, Lok, Sarah W Y, Xue, Rui, Zou, Yi-Xin, Chen, Wei, Lai, Kar-Neng, Tang, Sydney C W

“…Lipotoxicity has been implicated in the pathogenesis of obesity-related kidney damage and propagates chronic kidney injury like diabetic kidney disease;…”
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Novel mechanisms of tubulointerstitial injury in IgA nephropathy: a new therapeutic paradigm in the prevention of progressive renal failure by Chan, Loretta Y Y, Leung, Joseph C K, Lai, Kar Neng

“…IgA nephropathy (IgAN) runs a highly variable clinical course with frequent involvement of tubulointerstitial damage. Notably, renal progression correlates…”
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Lamivudine in hepatitis B-associated membranous nephropathy by Tang, Sydney, Lai, Fernand Mac-Moune, Lui, Yun Hoi, Tang, Colin S.O., Kung, Nelson N.S., Wing Ho, Yiu, Chan, Kwok Wah, Leung, Joseph C.K., Neng Lai, Kar

“…Lamivudine in hepatitis B-associated membranous nephropathy. Although lamivudine is effective for treatment of chronic hepatitis B (HBV) infection, its…”
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A Study of the Clinical and Biochemical Profile of Peritoneal Dialysis Fluid Low in Glucose Degradation Products by Lai, Kar Neng, Lam, Man Fai, Leung, Joseph C K, Chan, Loretta Y, Lam, Christopher W K, Chan, Iris H S, Chan, Hoi Wong, Li, Chun Sang, Wong, Sunny S H, Ho, Yiu Wing, Cheuk, Au, Tong, Matthew K L, Tang, Sydney C W

“…Although peritoneal dialysis (PD) is a widely accepted form of renal replacement therapy, concerns remain regarding the bioincompatible nature of standard PD…”
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Additive effect of PPAR-γ agonist and ARB in treatment of experimental IgA nephropathy by Lai, Kar Neng, Chan, Loretta Y. Y., Guo, Hong, Tang, Sydney C. W., Leung, Joseph C. K.

“…Our recent in vitro study demonstrated peroxisome proliferator-activated receptor-γ (PPAR−γ) agonist potentiated the anti-inflammatory effect of angiotensin…”
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Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal Dialysis by Lai, Kar Neng, Leung, Joseph C. K.

“…Adipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated…”
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Crosstalk between peroxisome proliferator-activated receptor-γ and angiotensin II in renal tubular epithelial cells in IgA nephropathy by Xiao, Jing, Leung, Joseph C.K, Chan, Loretta Y.Y, Tang, Sydney C.W, Lai, Kar Neng

“…Abstract Our recent study suggested that peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist attenuates inflammatory response in activated tubular…”
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