Search Results - "Leung, J Y Y"

Robust deep learning-based protein sequence design using ProteinMPNN by Dauparas, J, Anishchenko, I, Bennett, N, Bai, H, Ragotte, R J, Milles, L F, Wicky, B I M, Courbet, A, de Haas, R J, Bethel, N, Leung, P J Y, Huddy, T F, Pellock, S, Tischer, D, Chan, F, Koepnick, B, Nguyen, H, Kang, A, Sankaran, B, Bera, A K, King, N P, Baker, D

“…Although deep learning has revolutionized protein structure prediction, almost all experimentally characterized de novo protein designs have been generated…”
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A clinical prediction score using age at diagnosis and saline infusion test parameters can predict aldosterone-producing adenoma from idiopathic adrenal hyperplasia by Leung, H. T., Woo, Y. C., Fong, C. H. Y., Tan, K. C. B., Lau, E. Y. F., Chan, K. W., Leung, J. Y. Y.

“…Purpose Accurate subtyping of the primary aldosteronism into aldosterone-producing adenoma (APA) and idiopathic adrenal hyperplasia (IAH) is important to…”
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Olfactory ensheathing cells are attracted to, and can endocytose, bacteria by Leung, J. Y. K, Chapman, J. A, Harris, J. A, Hale, D, Chung, R. S, West, A. K, Chuah, M. I

“…Olfactory ensheathing cells (OECs) have been shown previously to express Toll-like receptors and to respond to bacteria by translocating nuclear factor-κB from…”
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A role for Myc in facilitating transcription activation by E2F1 by Leung, J Y, Ehmann, G L, Giangrande, P H, Nevins, J R

“…Previous work has demonstrated that E2F proteins regulate the expression of various genes encoding proteins essential for DNA replication and cell-cycle…”
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Minimizing maximum lateness of jobs in inventory constrained scheduling by Briskorn, D, Leung, J Y-T

“…This paper focuses on a machine scheduling problem having applications in truck scheduling at transshipment terminals. Jobs increase and decrease,…”
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De novo design of high-affinity binders of bioactive helical peptides by Vázquez Torres, Susana, Leung, Philip J. Y., Venkatesh, Preetham, Lutz, Isaac D., Hink, Fabian, Huynh, Huu-Hien, Becker, Jessica, Yeh, Andy Hsien-Wei, Juergens, David, Bennett, Nathaniel R., Hoofnagle, Andrew N., Huang, Eric, MacCoss, Michael J., Expòsit, Marc, Lee, Gyu Rie, Bera, Asim K., Kang, Alex, De La Cruz, Joshmyn, Levine, Paul M., Li, Xinting, Lamb, Mila, Gerben, Stacey R., Murray, Analisa, Heine, Piper, Korkmaz, Elif Nihal, Nivala, Jeff, Stewart, Lance, Watson, Joseph L., Rogers, Joseph M., Baker, David

“…Many peptide hormones form an α-helix on binding their receptors 1 – 4 , and sensitive methods for their detection could contribute to better clinical…”
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Cohort Profile: Hong Kong Department of Health Elderly Health Service Cohort by Schooling, C M, Chan, W M, Leung, S L, Lam, T H, Lee, S Y, Shen, C, Leung, J Y, Leung, G M

“…The Department of Health Elderly Health Service Cohort in Hong Kong was set up to promote understanding of ageing in a global context, to exploit the role of…”
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Orally consumed cannabinoids provide long-lasting relief of allodynia in a mouse model of chronic neuropathic pain by Abraham, Antony D, Leung, Edward J Y, Wong, Brenden A, Rivera, Zeena M G, Kruse, Lauren C, Clark, Jeremy J, Land, Benjamin B

“…Chronic pain affects a significant percentage of the United States population, and available pain medications like opioids have drawbacks that make long-term…”
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Effects of hypoxia on biofilms and subsequently larval settlement of benthic invertebrates by Cheung, S.G., Chan, C.Y.S., Po, B.H.K., Li, A.L., Leung, J.Y.S., Qiu, J.W., Ang, P.O., Thiyagarajan, V., Shin, P.K.S., Chiu, J.M.Y.

“…•Hypoxia altered the biofilm bacterial community composition.•Biofilms treated with hypoxia resulted in different benthic communities.•The hypoxic treatment…”
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Acute hypoxic exposure affects gamete quality and subsequent fertilization success and embryonic development in a serpulid polychaete by Shin, P.K.S., Leung, J.Y.S., Qiu, J.W., Ang, P.O., Chiu, J.M.Y., Thiyagarajan, V., Cheung, S.G.

“…•Sperm swimming activity dropped under hypoxia but not the egg size, complexity and viability.•Fertilization success was strongly associated with sperm…”
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Hypoxia induces abnormal larval development and affects biofilm–larval interaction in the serpulid polychaete Hydroides elegans by Shin, P.K.S., Leung, J.Y.S., Qiu, J.W., Ang, P.O., Chiu, J.M.Y., Thiyagarajan, V., Cheung, S.G.

“…•The effect of hypoxia on larval development and settlement of H. elegans was studied.•Larval development was delayed and more malformed larvae were found…”
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Effect of parental hypoxic exposure on embryonic development of the offspring of two serpulid polychaetes: Implication for transgenerational epigenetic effect by Leung, J.Y.S., Cheung, S.G., Qiu, J.W., Ang, P.O., Chiu, J.M.Y., Thiyagarajan, V., Shin, P.K.S.

“…•We studied parental hypoxic exposure effect on Hydroides elegans and Hydroides diramphus.•Gamete production, but not quality, was reduced after 2-week hypoxic…”
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Single batch machine scheduling with deliveries by Cheng, B.-Y., Leung, J.Y.-T., Li, K., Yang, S.-L.

“…We consider the problem of scheduling a set of n jobs on a single batch machine, where several jobs can be processed simultaneously. Each job j has a…”
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Glucose Transporters and FDG Uptake in Untreated Primary Human Non-Small Cell Lung Cancer by Brown, Raya S, Leung, Jennifer Y, Kison, Paul V, Zasadny, Kenneth R, Flint, Andrew, Wahl, Richard L

“…PET imaging of malignant tumors with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) as a tracer is a noninvasive diagnostic and prognostic tool that measures…”
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Effect of berberine on cardiovascular disease risk factors: abridged secondary publication by Zhao, J, Ip, D K M, Leung, J Y Y, Vackova, D, He, X, Schooling, C M

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Migrant status and childhood hospitalizations for asthma and other wheezing disorders by Leung, J. Y. Y., Leung, G. M., Schooling, C. M.

“…Summary Background In developed Western settings, asthma is more prevalent among second‐generation compared to first‐generation migrants. However, these…”
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Mode of delivery and childhood hospitalizations for asthma and other wheezing disorders by Leung, J. Y. Y., Li, A. M., Leung, G. M., Schooling, C. M.

“…Summary Background Observationally, delivery by Caesarean section is associated with higher risk of childhood asthma and wheeze in developed Western settings,…”
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HLA-B38:02:01 predicts carbimazole/methimazole-induced agranulocytosis by Cheung, C-L, Sing, C-W, Tang, CSM, Cheng, VKF, Pirmohamed, M, Choi, C-H, Hung, C-S, Lau, EY-F, Lee, KF, Mak, MW-H, Leung, JYY, Wong, T-W, Ho, AYY, Chan, K-W, Hung, VHF, Tam, V, Siu, S-C, Pang, H-K, Wat, WZ-M, Lee, HH-Y, Chung, C-T, Hue, RS-M, Sham, P-C, Cheung, BMY, Wong, ICK, Tan, KCB, Kung, AWC

“…Thioamides antithyroid‐drugs (ATDs) are important in hyperthyroid disease management. Identification of the susceptibility locus of ATD‐induced agranulocytosis…”
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Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways by Leung, Y.K.J., Pankhurst, M., Dunlop, S.A., Ray, S., Dittmann, J., Eaton, E.D., Palumaa, P., Sillard, R., Chuah, M.I., West, A.K., Chung, R.S.

“…Following central nervous system injury, astrocytes rapidly respond by undergoing a stereotypical pattern of molecular and morphological alterations termed…”
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TNF-α promoter single nucleotide polymorphisms are markers of human ancestry by Baena, A, Leung, J Y, Sullivan, A D, Landires, I, Vasquez-Luna, N, Quiñones-Berrocal, J, Fraser, P A, Uko, G P, Delgado, J C, Clavijo, O P, Thim, S, Meshnick, S R, Nyirenda, T, Yunis, E J, Goldfeld, A E

“…We present a map of single nucleotide polymorphisms (SNPs) in the human tumor necrosis factor (TNF)-alpha promoter based upon exploratory sequencing of 333…”
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