Search Results - "Leung, Ivanhoe"

Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery by Huang, Renjie, Leung, Ivanhoe K H

“…Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein…”
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Substrate specificity of polyphenol oxidase by McLarin, Mark-Anthony, Leung, Ivanhoe K H

“…The ubiquitous type-3 copper enzyme polyphenol oxidase (PPO) has found itself the subject of profound inhibitor research due to its role in fruit and vegetable…”
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Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target by Eurtivong, Chatchakorn, Leung, Euphemia, Sharma, Nabangshu, Leung, Ivanhoe K H, Reynisson, Jóhannes

“…Phosphatidylcholine-specific phospholipase C (PC-PLC) is an enzyme that catalyzes the formation of the important secondary messengers phosphocholine and…”
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MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance by Son, Soo Jung, Huang, Renjie, Squire, Christopher J., Leung, Ivanhoe K.H.

“…•MCR-1 is a phosphoethanolamine transferase that causes polymyxin resistance, an alarming global antibiotic resistance threat.•Zinc ions are critical for MCR-1…”
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Characterisation and optimisation of a novel laccase from Sulfitobacter indolifex for the decolourisation of organic dyes by Sharma, Nabangshu, Leung, Ivanhoe K.H.

“…Laccases are multi‑copper oxidases that possess the potential for industrial wastewater treatments. In this study, a putative laccase from Sulfitobacter…”
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Discovery of novel Hsp90 C-terminal domain inhibitors that disrupt co-chaperone binding by Mak, Oi Wei, Sharma, Nabangshu, Reynisson, Jóhannes, Leung, Ivanhoe K.H.

“…[Display omitted] Heat shock protein 90 (Hsp90) is an essential molecular chaperone that performs vital stress-related and housekeeping functions in cells and…”
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Synthesis of the Azepinobisindole Alkaloid Iheyamine A Enabled by a Cross-Mannich Reaction by Lindsay, Ashley C, Leung, Ivanhoe K. H, Sperry, Jonathan

“…The total synthesis of the azepinobisindole alkaloid iheyamine A is described. The successful strategy hinged on an intermolecular cross-Mannich reaction…”
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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases by Chowdhury, Rasheduzzaman, Yeoh, Kar Kheng, Tian, Ya-Min, Hillringhaus, Lars, Bagg, Eleanor A, Rose, Nathan R, Leung, Ivanhoe K H, Li, Xuan S, Woon, Esther C Y, Yang, Ming, McDonough, Michael A, King, Oliver N, Clifton, Ian J, Klose, Robert J, Claridge, Timothy D W, Ratcliffe, Peter J, Schofield, Christopher J, Kawamura, Akane

“…Mutations in isocitrate dehydrogenases (IDHs) have a gain‐of‐function effect leading to R (−)‐2‐hydroxyglutarate ( R‐ 2HG) accumulation. By using biochemical,…”
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A Critical Update on the Synthesis of Carboxylated Polymers of Intrinsic Microporosity (C-PIMs) by Santoso, Bagus, Yanaranop, Paam, Kang, Hong, Leung, Ivanhoe K. H, Jin, Jianyong

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Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials by Yeh, Tzu-Lan, Leissing, Thomas M, Abboud, Martine I, Thinnes, Cyrille C, Atasoylu, Onur, Holt-Martyn, James P, Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T, Leung, Ivanhoe K H, Morcrette, Helen, Clifton, Ian J, Claridge, Timothy D W, Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J, Chowdhury, Rasheduzzaman, Pugh, Christopher W, Schofield, Christopher J

“…Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1-3) causes upregulation of HIF, thus…”
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Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain by Chan, Mun Chiang, Atasoylu, Onur, Hodson, Emma, Tumber, Anthony, Leung, Ivanhoe K H, Chowdhury, Rasheduzzaman, Gómez-Pérez, Verónica, Demetriades, Marina, Rydzik, Anna M, Holt-Martyn, James, Tian, Ya-Min, Bishop, Tammie, Claridge, Timothy D W, Kawamura, Akane, Pugh, Christopher W, Ratcliffe, Peter J, Schofield, Christopher J

“…As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the…”
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Targeting mRNA translation in Parkinson’s disease by Correddu, Danilo, Leung, Ivanhoe K.H.

“…[Display omitted] •Parkinson’s disease (PD) is one of the most common neurodegenerative disorders.•Mutations in the genes that are involved in translation are…”
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases by Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Tian, Ya-Min, Abboud, Martine I., Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P., Pugh, Christopher W., Ratcliffe, Peter J., Claridge, Timothy D. W., Schofield, Christopher J.

“…The response to hypoxia in animals involves the expression of multiple genes regulated by the αβ-hypoxia-inducible transcription factors (HIFs). The…”
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Novel Thermophilic Bacterial Laccase for the Degradation of Aromatic Organic Pollutants by Sharma, Nabangshu, Leung, Ivanhoe K H

“…We identified a putative laccase from the thermophilic bacterium . The putative laccase was produced recombinantly and its ability to catalyse the degradation…”
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Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors by Shishodia, Shifali, Demetriades, Marina, Zhang, Dong, Tam, Nok Yin, Maheswaran, Pratheesh, Clunie-O’Connor, Caitlin, Tumber, Anthony, Leung, Ivanhoe K. H, Ng, Yi Min, Leissing, Thomas M, El-Sagheer, Afaf H, Salah, Eidarus, Brown, Tom, Aik, Wei Shen, McDonough, Michael A, Schofield, Christopher J

“…FTO catalyzes the Fe­(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N 6-methyladenosine (m6A) in mRNA…”
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An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant by Correddu, Danilo, Sharma, Nabangshu, Kaur, Simranjeet, Varnava, Kyriakos G, Mbenza, Naasson M, Sarojini, Vijayalekshmi, Leung, Ivanhoe K H

“…An investigation using recombinant ribosomal proteins and synthetic peptide models was conducted to uncover the effect of the introduction of a negative charge…”
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Assays to Study Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (PHD2), a Key Human Oxygen Sensing Protein by Chan, Yan Ying, Mbenza, Naasson M, Chan, Mun Chiang, Leung, Ivanhoe K H

“…Molecular oxygen is essential for all multicellular life forms. In humans, the hypoxia-inducible factor (HIF) prolyl hydroxylase domain-containing enzymes…”
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Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2 by Bhusal, Ram Prasad, Jiao, Wanting, Kwai, Brooke X. C., Reynisson, Jóhannes, Collins, Annabelle J., Sperry, Jonathan, Bashiri, Ghader, Leung, Ivanhoe K. H.

“…Isocitrate lyase is important for lipid utilisation by Mycobacterium tuberculosis but its ICL2 isoform is poorly understood. Here we report that binding of the…”
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A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold by Li-Zhulanov, Nikolai, Zakharenko, Alexandra, Chepanova, Arina, Patel, Jinal, Zafar, Ayesha, Volcho, Konstantin, Salakhutdinov, Nariman, Reynisson, Jóhannes, Leung, Ivanhoe, Lavrik, Olga

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the…”
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Targeting isocitrate lyase for the treatment of latent tuberculosis by Bhusal, Ram Prasad, Bashiri, Ghader, Kwai, Brooke X.C., Sperry, Jonathan, Leung, Ivanhoe K.H.

“…•Isocitrate lyase (ICL) is essential to growth and survival of Mycobacterium tuberculosis (Mtb).•ICL is involved in Mtb glyoxylate and methylisocitrate cycles,…”
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