Search Results - "Leung, Isabel"

Personality, self-appraisals, and body conscious emotions as predictors of symptoms of body dysmorphia and restrictive disordered eating by Du Rocher, Andrew R., Anderson, Carrie-Anne, Ashkar, Yasmin, Leung, Isabel, Lynch, Hayley, Shah, Maya, Vincent, Abigail, Watkinson, Katie

“…Anorexia nervosa and body dysmorphic disorder are often co-morbid and relate to distortions in the perception of self-appearance. It has been proposed that…”
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De novo design of potent and selective mimics of IL-2 and IL-15 by Silva, Daniel-Adriano, Yu, Shawn, Ulge, Umut Y., Spangler, Jamie B., Jude, Kevin M., Labão-Almeida, Carlos, Ali, Lestat R., Quijano-Rubio, Alfredo, Ruterbusch, Mikel, Leung, Isabel, Biary, Tamara, Crowley, Stephanie J., Marcos, Enrique, Walkey, Carl D., Weitzner, Brian D., Pardo-Avila, Fátima, Castellanos, Javier, Carter, Lauren, Stewart, Lance, Riddell, Stanley R., Pepper, Marion, Bernardes, Gonçalo, Dougan, Michael, Garcia, K. Christopher, Baker, David

“…© 2019 Springer Nature limited. All rights reserved. We describe a de novo computational approach for designing proteins that recapitulate the binding sites of…”
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A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents by Leung, Isabel, Jarvik, Nick, Sidhu, Sachdev S.

“…We report the design, construction, and validation of a highly diverse phage-displayed naïve ubiquitin variant (Ubv) library. We first conducted a mutation…”
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Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21 by Leung, Isabel, Dekel, Ayelet, Shifman, Julia M., Sidhu, Sachdev S.

“…A detailed understanding of the molecular mechanisms whereby ubiquitin (Ub) recognizes enzymes in the Ub proteasome system is crucial for understanding the…”
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Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function by Salter, Alexander I, Rajan, Anusha, Kennedy, Jacob J, Ivey, Richard G, Shelby, Sarah A, Leung, Isabel, Templeton, Megan L, Muhunthan, Vishaka, Voillet, Valentin, Sommermeyer, Daniel, Whiteaker, Jeffrey R, Gottardo, Raphael, Veatch, Sarah L, Paulovich, Amanda G, Riddell, Stanley R

“…Chimeric antigen receptor (CAR)-modified T cell therapy is effective in treating lymphomas, leukemias, and multiple myeloma in which the tumor cells express…”
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A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy by Quijano-Rubio, Alfredo, Bhuiyan, Aladdin M., Yang, Huilin, Leung, Isabel, Bello, Elisa, Ali, Lestat R., Zhangxu, Kevin, Perkins, Jilliane, Chun, Jung-Ho, Wang, Wentao, Lajoie, Marc J., Ravichandran, Rashmi, Kuo, Yun-Huai, Dougan, Stephanie K., Riddell, Stanley R., Spangler, Jamie B., Dougan, Michael, Silva, Daniel-Adriano, Baker, David

“…The therapeutic potential of recombinant cytokines has been limited by the severe side effects of systemic administration. We describe a strategy to reduce the…”
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Abstract 2222: Engineered variants of Neo-2/15 potently expand CAR-T cells and promote antitumor activity in lymphoma and solid tumor mouse models by Leung, Isabel, Templeton, Megan, Rubio, Alfredo, Walkey, Carl, Silva, Daniel-Adriano, Riddell, Stanley

“…Abstract Chimeric antigen receptor (CAR) T cells have achieved remarkable success as therapies for B cell malignancies, but failure might occur due to…”
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NOTCH1 signaling during CD4+ T-cell activation alters transcription factor networks and enhances antigen responsiveness by Wilkens, Alec B., Fulton, Elena C., Pont, Margot J., Cole, Gabriel O., Leung, Isabel, Stull, Sylvia M., Hart, Matthew R., Bernstein, Irwin D., Furlan, Scott N., Riddell, Stanley R.

“…•NOTCH1 signaling restricts naïve CD4+ T-cell differentiation and enhances CD4+ CAR-T proliferation and helper function.•NOTCH1 signaling programs distinct…”
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Ubiquitin Engineering: Understanding Ubiquitin Recognition and Generating Affinity Reagents by Leung, Isabel

“…Protein-protein interactions are necessary for virtually all biological processes. There have been tremendous efforts to document the diversity of molecular…”
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375 In vivo generation of universal CAR T cells that mediate durable anti-tumor immunity through combinatorial targeting with bispecific small molecule adapters by Mittelsteadt, Kristen, Leung, Isabel, Lynch, Kelsey, Chu, Haiyan, Chang-Chih, Wu, Shin, Seungjin, Larson, Ryan, Scharenberg, Andrew, Ryu, Byoung, Beitz, Laurie

“…BackgroundChimeric antigen receptor (CAR) T cell therapies have demonstrated limited efficacy against solid tumors, in part due to challenges overcoming solid…”
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Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function by Leung, Isabel, Templeton, Megan L., Lo, Yun, Rajan, Anusha, Stull, Sylvia M., Garrison, Sarah M., Salter, Alexander I., Smythe, Kimberly S., Correnti, Colin E., Srivastava, Shivani, Yeung, Cecilia C. S., Riddell, Stanley R.

“…•Bispecific CAR T cells circumvent outgrowth of antigen-negative tumor cells in vivo.•Tandem and bicistronic CARs have reduced sensitivity to single-antigen…”
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