Search Results - "Leung, Irene W L"

Enhanced antibody half-life improves in vivo activity by Karki, Sher, Leung, Irene W L, Horton, Holly M, Chamberlain, Aaron K, Roopenian, Derry C, Desjarlais, John R, Lazar, Greg A, Zalevsky, Jonathan, Sproule, Thomas J

“…Improved affinity for the neonatal Fc receptor (FcRn) is known to extend antibody half-life in vivo. However, this has never been linked with enhanced…”
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Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus by Horton, Holly M, Chu, Seung Y, Ortiz, Elizabeth C, Pong, Erik, Cemerski, Saso, Leung, Irene W L, Jacob, Noam, Zalevsky, Jonathan, Desjarlais, John R, Stohl, William, Szymkowski, David E

“…Engagement of the low-affinity Ab receptor FcγRIIb downregulates B cell activation, and its dysfunction is associated with autoimmunity in mice and humans. We…”
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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody by Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD

“…Background Sequestration of IgE to prevent its binding to high-affinity IgE receptor FcϵRI on basophils and mast cells is an effective therapy for allergic…”
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Engineering Fully Human Monoclonal Antibodies from Murine Variable Regions by Bernett, Matthew J., Karki, Sher, Moore, Gregory L., Leung, Irene W.L., Chen, Hsing, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Zalevsky, Jonathan, Muchhal, Umesh S., Desjarlais, John R., Lazar, Greg A.

“…Fully human monoclonal antibodies (mAbs) derived from transgenic mice or human antibody libraries are the current state of the art for reducing the…”
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The impact of Fc engineering on an anti-CD19 antibody: increased Fcγ receptor affinity enhances B-cell clearing in nonhuman primates by Zalevsky, Jonathan, Leung, Irene W.L., Karki, Sher, Chu, Seung Y., Zhukovsky, Eugene A., Desjarlais, John R., Carmichael, David F., Lawrence, Chris E.

“…CD19, a B cell–restricted receptor critical for B-cell development, is expressed in most B-cell malignancies. The Fc-engineered anti-CD19 antibody, XmAb5574,…”
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Abstract 5000: Immunotherapy with anti-PSMA x anti-CD3 bispecific antibody stimulates potent killing of a human prostate cancer cell line and target-mediated T cell activation in monkeys: A potential therapy for prostate cancer by Chu, Seung Y., Pong, Erik W. K., Rashid, Rumana, Chen, Hsing, Chan, Emily W., Phung, Sheryl, Endo, Nancy A., Ardila, Maria C., Bonzon, Christine, Leung, Irene W. L., Muchhal, Umesh S., Moore, Gregory L., Bernett, Matthew J., Desjarlais, John R., Szymkowski, David E.

“…PSMA (Prostate-Specific Membrane Antigen) is a promising therapeutic target in prostate cancer. Exploiting the high and selective expression of PSMA in the…”
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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIlb with Fc-engineered antibody by CHU, Seung Y, HORTON, Holly M, SZYMKOWSKI, David E, DESJARLAIS, John R, PONG, Erik, LEUNG, Irene W. L, HSING CHEN, NGUYEN, Duc-Hanh, BAUTISTA, Cristina, MUCHHAL, Umesh S, BERNETT, Matthew J, MOORE, Gregory L

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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and Fc[gamma]RIIb with Fc-engineered antibody by Chu, Seung Y, Horton, Holly M, Pong, Erik, Leung, Irene WL, Chen, Hsing, Nguyen, Duc-Hanh, Bautista, Cristina, Muchhal, Umesh S, Bernett, Matthew J, Moore, Gregory L, Szymkowski, David E, Desjarlais, John R

“…Background Sequestration of IgE to prevent its binding to high-affinity IgE receptor FcεRI on basophils and mast cells is an effective therapy for allergic…”
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The impact of Fc engineering on an anti-CD19 antibody: increased Fcgamma receptor affinity enhances B-cell clearing in nonhuman primates by Zalevsky, Jonathan, Leung, Irene W L, Karki, Sher, Chu, Seung Y, Zhukovsky, Eugene A, Desjarlais, John R, Carmichael, David F, Lawrence, Chris E

“…CD19, a B cell-restricted receptor critical for B-cell development, is expressed in most B-cell malignancies. The Fc-engineered anti-CD19 antibody, XmAb5574,…”
Get full text