Search Results - "Leung, Eleanor"

The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening by Vella, Peter, Hussein, Waleed M., Leung, Eleanor W.W., Clayton, Daniel, Ollis, David L., Mitić, Nataša, Schenk, Gerhard, McGeary, Ross P.

“…The emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of β-lactam antibiotics is particularly concerning for the future…”
Get full text

Applications of 19F-NMR in Fragment-Based Drug Discovery by Norton, Raymond, Leung, Eleanor, Chandrashekaran, Indu, MacRaild, Christopher

“…19 F-NMR has proved to be a valuable tool in fragment-based drug discovery. Its applications include screening libraries of fluorinated fragments, assessing…”
Get full text

Promiscuous 2‑Aminothiazoles (PrATs): A Frequent Hitting Scaffold by Devine, Shane M, Mulcair, Mark D, Debono, Cael O, Leung, Eleanor W. W, Nissink, J. Willem M, Lim, San Sui, Chandrashekaran, Indu R, Vazirani, Mansha, Mohanty, Biswaranjan, Simpson, Jamie S, Baell, Jonathan B, Scammells, Peter J, Norton, Raymond S, Scanlon, Martin J

“…We have identified a class of molecules, known as 2-aminothiazoles (2-ATs), as frequent-hitting fragments in biophysical binding assays. This was exemplified…”
Get full text

Applications of (19)F-NMR in Fragment-Based Drug Discovery by Norton, Raymond S, Leung, Eleanor W W, Chandrashekaran, Indu R, MacRaild, Christopher A

“…(19)F-NMR has proved to be a valuable tool in fragment-based drug discovery. Its applications include screening libraries of fluorinated fragments, assessing…”
Get full text

Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein–Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase by Harjani, Jitendra R, Yap, Beow Keat, Leung, Eleanor W. W, Lucke, Andrew, Nicholson, Sandra E, Scanlon, Martin J, Chalmers, David K, Thompson, Philip E, Norton, Raymond S, Baell, Jonathan B

“…SPRY domain-containing suppressor of cytokine signaling box protein (SPSB) 2-deficient macrophages have been found to exhibit prolonged expression of inducible…”
Get full text

Fragment-based and structure-guided discovery of perforin inhibitors by Jose, Jiney, Law, Ruby H.P., Leung, Eleanor W.W., Wai, Dorothy C.C., Akhlaghi, Hedieh, Chandrashekaran, Indu R., Caradoc-Davies, Tom T., Voskoboinik, Ilia, Feutrill, John, Middlemiss, David, Jeevarajah, Devadharshini, Bashtannyk-Puhalovich, Tanya, Giddens, Anna C., Lee, Tet Woo, Jamieson, Stephen M.F., Trapani, Joseph A., Whisstock, James C., Spicer, Julie A., Norton, Raymond S.

“…Perforin is a pore-forming protein whose normal function enables cytotoxic T and natural killer (NK) cells to kill virus-infected and transformed cells…”
Get full text

A Potent Cyclic Peptide Targeting SPSB2 Protein as a Potential Anti-infective Agent by Yap, Beow Keat, Leung, Eleanor W. W, Yagi, Hiromasa, Galea, Charles A, Chhabra, Sandeep, Chalmers, David K, Nicholson, Sandra E, Thompson, Philip E, Norton, Raymond S

“…The protein SPSB2 mediates proteosomal degradation of inducible nitric oxide synthase (iNOS). Inhibitors of SPSB2–iNOS interaction may prolong the lifetime of…”
Get full text

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria by Chang, Shih Chieh, Galea, Charles A., Leung, Eleanor W.W., Tajhya, Rajeev B., Beeton, Christine, Pennington, Michael W., Norton, Raymond S.

“…The polypeptide toxin ShK is a potent blocker of Kv1.3 potassium channels, which play a crucial role in the activation of human effector memory T-cells (TEM)…”
Get full text

The Single Disulfide-Directed β‑Hairpin Fold. Dynamics, Stability, and Engineering by Chittoor, Balasubramanyam, Krishnarjuna, Bankala, Morales, Rodrigo A. V, MacRaild, Christopher A, Sadek, Maiada, Leung, Eleanor W. W, Robinson, Samuel D, Pennington, Michael W, Norton, Raymond S

“…Grafting bioactive peptide sequences onto small cysteine-rich scaffolds is a promising strategy for enhancing their stability and value as novel peptide-based…”
Get full text

A Cyclic Peptide Inhibitor of the iNOS–SPSB Protein–Protein Interaction as a Potential Anti-Infective Agent by Sadek, Maiada M, Barlow, Nicholas, Leung, Eleanor W. W, Williams-Noonan, Billy J, Yap, Beow Keat, Shariff, Fairolniza Mohd, Caradoc-Davies, Tom T, Nicholson, Sandra E, Chalmers, David K, Thompson, Philip E, Law, Ruby H. P, Norton, Raymond S

“…SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4 interact with inducible nitric oxide synthase (iNOS), causing the iNOS to be…”
Get full text

Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N‑Terminus of SOCS5 by Chandrashekaran, Indu R, Mohanty, Biswaranjan, Linossi, Edmond M, Dagley, Laura F, Leung, Eleanor W. W, Murphy, James M, Babon, Jeffrey J, Nicholson, Sandra E, Norton, Raymond S

“…SOCS5 can negatively regulate both JAK/STAT and EGF-receptor pathways and has therefore been implicated in regulating both the immune response and…”
Get full text

Conformational Changes in a Plant Ketol-Acid Reductoisomerase upon Mg2+ and NADPH Binding as Revealed by Two Crystal Structures by Leung, Eleanor W.W., Guddat, Luke W.

“…Ketol-acid reductoisomerase (KARI; EC 1.1.1.86) is an enzyme in the branched-chain amino acid biosynthesis pathway where it catalyzes the conversion of…”
Get full text

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes by Yagi, Hiromasa, Conroy, Paul J., Leung, Eleanor W.W., Law, Ruby H.P., Trapani, Joseph A., Voskoboinik, Ilia, Whisstock, James C., Norton, Raymond S.

“…Natural killer cells and cytotoxic T-lymphocytes deploy perforin and granzymes to kill infected host cells. Perforin, secreted by immune cells, binds target…”
Get full text

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding by Quek, Adam J.H., Mazzitelli, Blake A., Wu, Guojie, Leung, Eleanor W.W., Caradoc-Davies, Tom T., Lloyd, Gordon J., Jeevarajah, Devadharshini, Conroy, Paul J., Sanderson-Smith, Martina, Yuan, Yue, Ayinuola, Yetunde A., Castellino, Francis J., Whisstock, James C., Law, Ruby H.P.

“…Plasminogen (Plg)-binding M protein (PAM) is a group A streptococcal cell surface receptor that is crucial for bacterial virulence. Previous studies revealed…”
Get full text

Redox‐stable cyclic peptide inhibitors of the SPSB2–iNOS interaction by Yap, Beow Keat, Harjani, Jitendra R., Leung, Eleanor W. W., Nicholson, Sandra E., Scanlon, Martin J., Chalmers, David K., Thompson, Philip E., Baell, Jonathan B., Norton, Raymond S.

“…SPSB2 mediates the proteasomal degradation of iNOS. Inhibitors of SPSB2–iNOS interaction are expected to prolong iNOS lifetime and thereby enhance killing of…”
Get full text

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9 by Bayly-Jones, Charles, Ho, Bill H. T., Lau, Corinna, Leung, Eleanor W. W., D’Andrea, Laura, Lupton, Christopher J., Ekkel, Susan M., Venugopal, Hariprasad, Whisstock, James C., Mollnes, Tom E., Spicer, Bradley A., Dunstone, Michelle A.

“…The Membrane Attack Complex (MAC) is responsible for forming large β-barrel channels in the membranes of pathogens, such as gram-negative bacteria. Off-target…”
Get full text

Identification and characterization of an unusual metallo-β-lactamase from Serratia proteamaculans by Vella, Peter, Miraula, Manfredi, Phelan, Emer, Leung, Eleanor W. W., Ely, Fernanda, Ollis, David L., McGeary, Ross P., Schenk, Gerhard, Mitić, Nataša

“…Metallo-β-lactamases (MBLs) are a family of metalloenzymes that are capable of hydrolyzing β-lactam antibiotics and are an important means by which bacterial…”
Get full text

Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue by Drane, Stephen B., Robinson, Samuel D., MacRaild, Christopher A., Chhabra, Sandeep, Chittoor, Balasubramanyam, Morales, Rodrigo A.V., Leung, Eleanor W.W., Belgi, Alessia, Espino, Samuel S., Olivera, Baldomero M., Robinson, Andrea J., Chalmers, David K., Norton, Raymond S.

“…In natural proteins and peptides, amino acids exist almost invariably as l-isomers. There are, however, several examples of naturally-occurring peptides…”
Get full text

Defining the interaction of perforin with calcium and the phospholipid membrane by Traore, Daouda A K, Brennan, Amelia J, Law, Ruby H P, Dogovski, Con, Perugini, Matthew A, Lukoyanova, Natalya, Leung, Eleanor W W, Norton, Raymond S, Lopez, Jamie A, Browne, Kylie A, Yagita, Hideo, Lloyd, Gordon J, Ciccone, Annette, Verschoor, Sandra, Trapani, Joseph A, Whisstock, James C, Voskoboinik, Ilia

“…Following its secretion from cytotoxic lymphocytes into the immune synapse, perforin binds to target cell membranes through its Ca(2+)-dependent C2 domain…”
Get more information

Randomized Trial of Dose-Dense Versus Conventionally Scheduled and Sequential Versus Concurrent Combination Chemotherapy as Postoperative Adjuvant Treatment of Node-Positive Primary Breast Cancer: First Report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741 by CITRON, Marc L, BERRY, Donald A, PEREZ, Edith A, CARPENTER, John, HURD, David, HOLLAND, James F, SMITH, Barbara L, SARTOR, Carolyn I, LEUNG, Eleanor H, ABRAMS, Jeffrey, SCHILSKY, Richard L, MUSS, Hyman B, CIRRINCIONE, Constance, NORTON, Larry, HUDIS, Clifford, WINER, Eric P, GRADISHAR, William J, DAVIDSON, Nancy E, MARTINO, Silvana, LIVINGSTON, Robert, INGLE, James N

“…Using a 2 x 2 factorial design, we studied the adjuvant chemotherapy of women with axillary node-positive breast cancer to compare sequential doxorubicin (A),…”
Get full text