Search Results - "Leung, Cecilia S."

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1 by Au Yeung, Chi Lam, Co, Ngai-Na, Tsuruga, Tetsushi, Yeung, Tsz-Lun, Kwan, Suet-Ying, Leung, Cecilia S., Li, Yong, Lu, Edward S., Kwan, Kenny, Wong, Kwong-Kwok, Schmandt, Rosemarie, Lu, Karen H., Mok, Samuel C.

“…Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum. However, the omental stromal cell-derived molecular determinants that…”
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Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis by Yeung, Tsz-Lun, Leung, Cecilia S, Yip, Kay-Pong, Au Yeung, Chi Lam, Wong, Stephen T C, Mok, Samuel C

“…Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late stage, with a 5-yr survival rate of <30%. The majority of ovarian…”
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Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance by Leung, Cecilia S, Yeung, Tsz-Lun, Yip, Kay-Pong, Wong, Kwong-Kwok, Ho, Samuel Y, Mangala, Lingegowda S, Sood, Anil K, Lopez-Berestein, Gabriel, Sheng, Jianting, Wong, Stephen Tc, Birrer, Michael J, Mok, Samuel C

“…The molecular mechanism by which cancer-associated fibroblasts (CAFs) confer chemoresistance in ovarian cancer is poorly understood. The purpose of the present…”
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ELF3 is a negative regulator of epithelial-mesenchymal transition in ovarian cancer cells by Yeung, Tsz-Lun, Leung, Cecilia S, Wong, Kwong-Kwok, Gutierrez-Hartmann, Arthur, Kwong, Joseph, Gershenson, David M, Mok, Samuel C

“…Transcription factors are master switches for various biochemical pathways. However, transcription factors involved in the pathogenesis of ovarian cancer have…”
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Identification of FGFR4 as a Potential Therapeutic Target for Advanced-Stage, High-Grade Serous Ovarian Cancer by ZAID, Tarrik M, YEUNG, Tsz-Lun, SOOD, Anil K, WONG, Kwong-Kwok, BIRRER, Michael J, MOK, Samuel C, THOMPSON, Melissa S, LEUNG, Cecilia S, HARDING, Tom, CO, Ngai-Na, SCHMANDT, Rosie S, KWAN, Suet-Ying, RODRIGUEZ-AGUAY, Cristian, LOPEZ-BERESTEIN, Gabriel

“…To evaluate the prognostic value of fibroblast growth factor receptor 4 (FGFR4) protein expression in patients with advanced-stage, high-grade serous ovarian…”
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Targeting Stromal-Cancer Cell Crosstalk Networks in Ovarian Cancer Treatment by Yeung, Tsz-Lun, Leung, Cecilia S, Li, Fuhai, Wong, Stephen S T, Mok, Samuel C

“…Ovarian cancer is a histologically, clinically, and molecularly diverse disease with a five-year survival rate of less than 30%. It has been estimated that…”
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TGF-β Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment is by YEUNG, Tsz-Lun, LEUNG, Cecilia S, WONG, Kwong-Kwok, SAMIMI, Goli, THOMPSON, Melissa S, JINSONG LIU, ZAID, Tarrik M, GHOSH, Sue, BIRRER, Michael J, MOK, Samuel C

“…TGF-β has limited effects on ovarian cancer cells, but its contributions to ovarian tumor growth might be mediated through elements of the tumor…”
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Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer by Yeung, Tsz-Lun, Leung, Cecilia S, Yip, Kay-Pong, Sheng, Jianting, Vien, Long, Bover, Laura C, Birrer, Michael J, Wong, Stephen T C, Mok, Samuel C

“…Recent studies demonstrate the role of the tumor microenvironment in tumor progression. However, strategies used to overcome the malignant phenotypes of cancer…”
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Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential by Leung, Cecilia S., Yeung, Tsz-Lun, Yip, Kay-Pong, Pradeep, Sunila, Balasubramanian, Lavanya, Liu, Jinsong, Wong, Kwong-Kwok, Mangala, Lingegowda S., Armaiz-Pena, Guillermo N., Lopez-Berestein, Gabriel, Sood, Anil K., Birrer, Michael J., Mok, Samuel C.

“…Ovarian cancer is the most lethal gynaecologic malignancy in the United States, and advanced serous ovarian adenocarcinoma is responsible for most ovarian…”
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Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer by Yeung, Tsz-Lun, Sheng, Jianting, Leung, Cecilia S, Li, Fuhai, Kim, Jaeyeon, Ho, Samuel Y, Matzuk, Martin M, Lu, Karen H, Wong, Stephen T C, Mok, Samuel C

“…Bulk tumor tissue samples are used for generating gene expression profiles in most research studies, making it difficult to decipher the stroma-cancer…”
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Abstract 4145: Stromal heterogeneity and immune response in ovarian cancer by Yeung, Tsz-Lun, Leung, Cecilia S., Wong, Kwong-Kwok, Mok, Samuel C.

“…Abstract Ovarian cancer is the most lethal gynecologic malignancy in the US. Our group and others has shown that CD8+ lymphocyte infiltration in the ovarian…”
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ISG15 Promotes ERK1 ISGylation, CD8+ T Cell Activation and Suppresses Ovarian Cancer Progression by Yeung, Tsz-Lun, Tsai, Ching Chou, Leung, Cecilia S, Au Yeung, Chi-Lam, Thompson, Melissa S, Lu, Karen H, Freedman, Ralph S, Birrer, Michael J, Wong, Kwong-Kwok, Mok, Samuel C

“…Increased number of tumor-infiltrating CD8+ lymphocytes is associated with improved survival in patients with advanced stage high grade serous ovarian cancer…”
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Intra-arterial revascularisation therapy for acute ischaemic stroke: initial experience in a Hong Kong hospital by Wong, Edward H C, Yu, Simon C H, Lau, Alexander Y L, Hui, Venus S W, Leung, Cecilia S F, Hui, Joyce W Y, Siu, Deyond Y W, Abrigo, Jill M, Lee, K T, Graham, Colin A, Wong, Lawrence K S, Leung, Thomas W H

“…To assess the outcome of acute ischaemic stroke patients who received intra-arterial therapy in our unit. Case series. A tertiary hospital in Hong Kong…”
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CAF reprogramming inhibits ovarian cancer progression by Yeung, Tsz-Lun, Leung, Cecilia S, Mok, Samuel C

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THEO concept mission: Testing the Habitability of Enceladus’s Ocean by MacKenzie, Shannon M., Caswell, Tess E., Phillips-Lander, Charity M., Stavros, E. Natasha, Hofgartner, Jason D., Sun, Vivian Z., Powell, Kathryn E., Steuer, Casey J., O’Rourke, Joseph G., Dhaliwal, Jasmeet K., Leung, Cecilia W.S., Petro, Elaine M., Wynne, J. Judson, Phan, Samson, Crismani, Matteo, Krishnamurthy, Akshata, John, Kristen K., DeBruin, Kevin, Budney, Charles J., Mitchell, Karl L.

“…Saturn’s moon Enceladus offers a unique opportunity in the search for life and habitable environments beyond Earth, a key theme of the National Research…”
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Abstract 2232: A novel immune checkpoint regulator in the ovarian cancer microenvironment by Borgogno, Sammy Ferri, Yeung, Tsz-Lun, Leung, Cecilia S., Yeung, Chi Lam Au, Zhu, Ying, Wong, Stephen T., Mok, Samuel C.

“…Abstract High-grade serous ovarian cancer (HGSC) is the most lethal gynecologic malignancy, accounting for 70-80% of ovarian cancer deaths worldwide. Despite…”
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Abstract B045: A novel immune checkpoint regulator in the ovarian cancer microenvironment by Borgogno, Sammy Ferri, Yeung, Tsz-Lun, Leung, Cecilia S, Yeung, Chi Lam Au, Zhu, Ying, Wong, Stephen T, Mok, Samuel C

“…Abstract High-grade serous ovarian cancer (HGSC) is the most lethal gynecologic malignancy, accounting for 70–80% of ovarian cancer deaths worldwide. Despite…”
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Multimodal computed tomography evaluation before thrombolysis in acute ischaemic stroke by Leung, Thomas W, Lam, Wynnie W M, Yu, Simon C H, Leung, Cecilia S F, Soo, Yannie O Y, Wong, Lawrence K S

“…Currently, when stroke patients are offered thrombolytic therapy, their ischaemic stroke subtypes are usually unknown. Given the risk of haemorrhage that…”
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Abstract 5066: Reprogramming the TGF-beta signaling in cancer-associated fibroblasts inhibits ovarian cancer progression by Yeung, Tsz-Lun, Leung, Cecilia S., Wong, Kwong-Kwok, Mok, Samuel C.

“…Abstract Ovarian cancer is the most lethal gynecologic malignancy in the US. While major research efforts have been dedicated to identify disease related genes…”
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Abstract LB-214: The immunosuppressive roles of ovarian stromal tumor microenvironment by Yeung, Tsz-Lun, Leung, Cecilia S., Wong, Kwong-Kwok, Birrer, Michael J., Wong, Stephen T., Lu, Karen H., Mok, Samuel C.

“…Abstract Ovarian cancer is the most lethal gynecologic malignancy in the US. Our group and others has shown that CD8+ lymphocyte infiltration in the ovarian…”
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