Search Results - "Leung, Carol S"

Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas by Tsai, Ming-Han, Raykova, Ana, Klinke, Olaf, Bernhardt, Katharina, Gärtner, Kathrin, Leung, Carol S., Geletneky, Karsten, Sertel, Serkan, Münz, Christian, Feederle, Regina, Delecluse, Henri-Jacques

“…The Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence greatly varies around the world. A poorly explored hypothesis is that particular…”
Get full text

Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection by Chijioke, Obinna, Müller, Anne, Feederle, Regina, Barros, Mario Henrique M., Krieg, Carsten, Emmel, Vanessa, Marcenaro, Emanuela, Leung, Carol S., Antsiferova, Olga, Landtwing, Vanessa, Bossart, Walter, Moretta, Alessandro, Hassan, Rocio, Boyman, Onur, Niedobitek, Gerald, Delecluse, Henri-Jacques, Capaul, Riccarda, Münz, Christian

“…Primary infection with the human oncogenic Epstein-Barr virus (EBV) can result in infectious mononucleosis (IM), a self-limiting disease caused by massive…”
Get full text

Analysis of ROR1 Protein Expression in Mice with Reconstituted Human Immune System Components by Leung, Carol

“…Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal antigen expressed on multiple tumors and has no significant expression on normal human…”
Get full text

Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display by Leung, Carol S, Haigh, Tracey A, Mackay, Laura K, Rickinson, Alan B, Taylor, Graham S

“…Whereas exogenously acquired proteins are the major source of antigens feeding the MHC class II pathway in antigen-presenting cells, some endogenously…”
Get full text

Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral IRF3 Modulates Major Histocompatibility Complex Class II (MHC-II) Antigen Presentation through MHC-II Transactivator-Dependent and -Independent Mechanisms: Implications for Oncogenesis by Zuo, Jianmin, Hislop, Andrew D, Leung, Carol S, Sabbah, Shereen, Rowe, Martin

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
Get full text

Vaccination against the Epstein–Barr virus by Rühl, Julia, Leung, Carol S., Münz, Christian

“…Epstein–Barr virus (EBV) was the first human tumor virus being discovered and remains to date the only human pathogen that can transform cells in vitro…”
Get full text

Nuclear shelter: The influence of subcellular location on the processing of antigens by macroautophagy by Leung, Carol S., Taylor, Graham S.

“…CD4 + T cells recognize peptides displayed by MHC II molecules on the surface of specialized antigen-presenting cells (APCs). These peptides are generally…”
Get full text

T cell detection of a B-cell tropic virus infection: newly-synthesised versus mature viral proteins as antigen sources for CD4 and CD8 epitope display by Mackay, Laura K, Long, Heather M, Brooks, Jill M, Taylor, Graham S, Leung, Carol S, Chen, Adrienne, Wang, Fred, Rickinson, Alan B

“…Viruses that naturally infect cells expressing both MHC I and MHC II molecules render themselves potentially visible to both CD8+ and CD4+ T cells through the…”
Get full text

Heterologous prime-boost vaccination protects against EBV antigen-expressing lymphomas by Rühl, Julia, Citterio, Carmen, Engelmann, Christine, Haigh, Tracey, Dzionek, Andrzej, Dreyer, Johannes, Khanna, Rajiv, Taylor, Graham S, Wilson, Joanna B, Leung, Carol S, Münz, Christian

“…The Epstein-Barr virus (EBV) is one of the predominant tumor viruses in humans, but so far no therapeutic or prophylactic vaccination against this transforming…”
Get full text

Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection by Chijioke, Obinna, Müller, Anne, Feederle, Regina, Barros, Mario Henrique M., Krieg, Carsten, Emmel, Vanessa, Marcenaro, Emanuela, Leung, Carol S., Antsiferova, Olga, Landtwing, Vanessa, Bossart, Walter, Moretta, Alessandro, Hassan, Rocio, Boyman, Onur, Niedobitek, Gerald, Delecluse, Henri-Jacques, Capaul, Riccarda, Münz, Christian

Get full text

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1 by Peng, Ruoshi, Wang, Chris Kedong, Wang‐Kan, Xuan, Idorn, Manja, Kjær, Majken, Zhou, Felix Y, Fiil, Berthe Katrine, Timmermann, Frederik, Orozco, Susana L, McCarthy, Julia, Leung, Carol S, Lu, Xin, Bagola, Katrin, Rehwinkel, Jan, Oberst, Andrew, Maelfait, Jonathan, Paludan, Søren R, Gyrd‐Hansen, Mads

“…ZBP1 is an interferon‐induced cytosolic nucleic acid sensor that facilitates antiviral responses via RIPK3. Although ZBP1‐mediated programmed cell death is…”
Get full text

CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice by Meixlsperger, Sonja, Leung, Carol S., Rämer, Patrick C., Pack, Maggi, Vanoaica, Liliana D., Breton, Gaëlle, Pascolo, Steve, Salazar, Andres M., Dzionek, Andrzej, Schmitz, Jürgen, Steinman, Ralph M., Münz, Christian

“…Functional differences between human dendritic cell (DC) subsets and the potential benefits of targeting them with vaccines remain poorly defined. Here we…”
Get full text

Endogenous Antigen Presentation of MHC Class II Epitopes through Non-Autophagic Pathways by Leung, Carol S K

“…Antigenic peptides presented by major histocompatibility complex (MHC) class II molecules are generally derived from exogenous proteins acquired by antigen…”
Get full text

Robust T-cell stimulation by Epstein-Barr virus–transformed B cells after antigen targeting to DEC-205 by Leung, Carol S., Maurer, Michael A., Meixlsperger, Sonja, Lippmann, Anne, Cheong, Cheolho, Zuo, Jianmin, Haigh, Tracey A., Taylor, Graham S., Münz, Christian

“…DEC-205 is a type I transmembrane multilectin receptor that is predominantly expressed on dendritic cells (DCs). Therefore, previous studies primarily focused…”
Get full text

Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity by Maurer, Michael A, Rakocevic, Goran, Leung, Carol S, Quast, Isaak, Lukačišin, Martin, Goebels, Norbert, Münz, Christian, Wardemann, Hedda, Dalakas, Marinos, Lünemann, Jan D

“…The B cell-depleting IgG1 monoclonal antibody rituximab can persistently suppress disease progression in some patients with autoimmune diseases. However, the…”
Get full text

Mice with human immune system components as in vivo models for infections with human pathogens by Rämer, Patrick C, Chijioke, Obinna, Meixlsperger, Sonja, Leung, Carol S, Münz, Christian

“…Many pathogens relevant to human disease do not infect other animal species. Therefore, animal models that reconstitute or harbor human tissues are explored as…”
Get full text

Heterologous prime-boost vaccination protects from EBV antigen expressing lymphomas by Rühl, Julia, Citterio, Carmen, Engelmann, Christine, Haigh, Tracey A, Dzionek, Andrzej, Dreyer, Johannes H, Khanna, Rajiv, Taylor, Graham S, Wilson, Joanna B, Leung, Carol S, Münz, Christian

“…The Epstein Barr virus (EBV) is one of the predominant tumor viruses in humans, but so far no therapeutic or prophylactic vaccination against this transforming…”
Get full text

T Cell Detection of a B-Cell Tropic Virus Infection: Newly-Synthesised versus Mature Viral Proteins as Antigen Sources for CD4 and CD8 Epitope Display: e1000699 by Mackay, Laura K, Long, Heather M, Brooks, Jill M, Taylor, Graham S, Leung, Carol S, Chen, Adrienne, Wang, Fred, Rickinson, Alan B

“…Viruses that naturally infect cells expressing both MHC I and MHC II molecules render themselves potentially visible to both CD8+ and CD4+ T cells through the…”
Get full text