Search Results - "Leube, Rudolf E."

Keratin intermediate filaments: intermediaries of epithelial cell migration by Yoon, Sungjun, Leube, Rudolf E

“…Migration of epithelial cells is fundamental to multiple developmental processes, epithelial tissue morphogenesis and maintenance, wound healing and…”
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Hemidesmosome-Related Keratin Filament Bundling and Nucleation by Moch, Marcin, Leube, Rudolf E

“…The epithelial cytoskeleton encompasses actin filaments, microtubules, and keratin intermediate filaments. They are interconnected and attached to the…”
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Intermediate filaments and the regulation of focal adhesion by Leube, Rudolf E, Moch, Marcin, Windoffer, Reinhard

“…Focal adhesions are localized actin filament-anchoring signalling centres at the cell–extracellular matrix interface. The currently emerging view is that they…”
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Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia by Windoffer, Reinhard, Beil, Michael, Magin, Thomas M, Leube, Rudolf E

“…Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are abundant in epithelia and form cytoskeletal networks that contribute to…”
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Keratins as the main component for the mechanical integrity of keratinocytes by Ramms, Lena, Fabris, Gloria, Windoffer, Reinhard, Schwarz, Nicole, Springer, Ronald, Zhou, Chen, Lazar, Jaroslav, Stiefel, Simone, Hersch, Nils, Schnakenberg, Uwe, Magin, Thomas M., Leube, Rudolf E., Merkel, Rudolf, Hoffmann, Bernd

“…Keratins are major components of the epithelial cytoskeleton and are believed to play a vital role for mechanical integrity at the cellular and tissue level…”
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Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosis by Gordon, Sarah L, Leube, Rudolf E, Cousin, Michael A

“…The integral synaptic vesicle (SV) protein synaptophysin forms ∼10% of total SV protein content, but has no known function in SV physiology. Synaptobrevin…”
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An Assessment of the Mechanophysical and Hormonal Impact on Human Endometrial Epithelium Mechanics and Receptivity by Sternberg, Anna K, Izmaylova, Liubov, Buck, Volker U, Classen-Linke, Irmgard, Leube, Rudolf E

“…The endometrial epithelium and underlying stroma undergo profound changes to support and limit embryo adhesion and invasion, which occur in the secretory phase…”
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Structural and regulatory functions of keratins by Magin, Thomas M., Vijayaraj, Preethi, Leube, Rudolf E.

“…The diversity of epithelial functions is reflected by the expression of distinct keratin pairs that are responsible to protect epithelial cells against…”
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Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart by Moazzen, Hoda, Venger, Kateryna, Kant, Sebastian, Leube, Rudolf E., Krusche, Claudia A.

“…Cardiac morphogenesis relies on intricate intercellular signaling. Altered signaling impacts cardiac function and is detrimental to embryonic survival. Here we…”
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Identification of a Novel Link between the Intermediate Filament Organizer IFO-1 and Cholesterol Metabolism in the Caenorhabditis elegans Intestine by Coch, Richard A., Geisler, Florian, Annibal, Andrea, Antebi, Adam, Leube, Rudolf E.

“…The intestine is an organ essential to organismal nutrient absorption, metabolic control, barrier function and immunoprotection. The intestine consists of 20…”
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Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions by Geisler, Florian, Remmelzwaal, Sanne, Jankowski, Vera, Schmidt, Ruben, Boxem, Mike, Leube, Rudolf E

“…Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization…”
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Intermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and Function by Schwarz, Nicole, Leube, Rudolf E

“…Intermediate filaments together with actin filaments and microtubules form the cytoskeleton, which is a complex and highly dynamic 3D network. Intermediate…”
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Dissection of keratin network formation, turnover and reorganization in living murine embryos by Schwarz, Nicole, Windoffer, Reinhard, Magin, Thomas M., Leube, Rudolf E.

“…Epithelial functions are fundamentally determined by cytoskeletal keratin network organization. However, our understanding of keratin network plasticity is…”
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A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity by Kumar, Vinod, Bouameur, Jamal-Eddine, Bär, Janina, Rice, Robert H, Hornig-Do, Hue-Tran, Roop, Dennis R, Schwarz, Nicole, Brodesser, Susanne, Thiering, Sören, Leube, Rudolf E, Wiesner, Rudolf J, Vijayaraj, Preethi, Brazel, Christina B, Heller, Sandra, Binder, Hans, Löffler-Wirth, Henry, Seibel, Peter, Magin, Thomas M

“…Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth. The…”
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Measuring the regulation of keratin filament network dynamics by Moch, Marcin, Herberich, Gerlind, Aach, Til, Leube, Rudolf E., Windoffer, Reinhard

“…The organization of the keratin intermediate filament cytoskeleton is closely linked to epithelial function. To study keratin network plasticity and its…”
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Desmosomes in Cell Fate Determination: From Cardiogenesis to Cardiomyopathy by Moazzen, Hoda, Bolaji, Mistura Dolapo, Leube, Rudolf E

“…Desmosomes play a vital role in providing structural integrity to tissues that experience significant mechanical tension, including the heart. Deficiencies in…”
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Effects of Plectin Depletion on Keratin Network Dynamics and Organization by Moch, Marcin, Windoffer, Reinhard, Schwarz, Nicole, Pohl, Raphaela, Omenzetter, Andreas, Schnakenberg, Uwe, Herb, Fabian, Chaisaowong, Kraisorn, Merhof, Dorit, Ramms, Lena, Fabris, Gloria, Hoffmann, Bernd, Merkel, Rudolf, Leube, Rudolf E

“…The keratin intermediate filament cytoskeleton protects epithelial cells against various types of stress and is involved in fundamental cellular processes such…”
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Cortical tension regulates desmosomal morphogenesis by Moch, Marcin, Schieren, Jana, Leube, Rudolf E.

“…Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are…”
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Desmoglein 2-Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function by Kant, Sebastian, Holthöfer, Bastian, Magin, Thomas M, Krusche, Claudia A, Leube, Rudolf E

“…The desmosomal cadherin desmoglein 2 (Dsg2) localizes to the intercalated disc coupling adjacent cardiomyocytes. Desmoglein 2 gene (DSG2) mutations cause…”
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Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor by Vijayaraj, Preethi, Kröger, Cornelia, Reuter, Ursula, Windoffer, Reinhard, Leube, Rudolf E, Magin, Thomas M

“…Keratin intermediate filament proteins form cytoskeletal scaffolds in epithelia, the disruption of which affects cytoarchitecture, cell growth, survival, and…”
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