Search Results - "Letvin, Norman L."

Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genes by Reddi, Tejaswini S, Merkl, Philipp E, Lim, So-Yon, Letvin, Norman L, Knipe, David M

“…Intrinsic resistance is a crucial line of defense against virus infections, and members of the Tripartite Ring Interaction Motif (TRIM) family of proteins are…”
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Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2 by Liao, Hua-Xin, Bonsignori, Mattia, Alam, S. Munir, McLellan, Jason S., Tomaras, Georgia D., Moody, M. Anthony, Kozink, Daniel M., Hwang, Kwan-Ki, Chen, Xi, Tsao, Chun-Yen, Liu, Pinghuang, Lu, Xiaozhi, Parks, Robert J., Montefiori, David C., Ferrari, Guido, Pollara, Justin, Rao, Mangala, Peachman, Kristina K., Santra, Sampa, Letvin, Norman L., Karasavvas, Nicos, Yang, Zhi-Yong, Dai, Kaifan, Pancera, Marie, Gorman, Jason, Wiehe, Kevin, Nicely, Nathan I., Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Tartaglia, James, Sinangil, Faruk, Kim, Jerome H., Michael, Nelson L., Kepler, Thomas B., Kwong, Peter D., Mascola, John R., Nabel, Gary J., Pinter, Abraham, Zolla-Pazner, Susan, Haynes, Barton F.

“…The RV144 HIV-1 trial of the canary pox vector (ALVAC-HIV) plus the gp120 AIDSVAX B/E vaccine demonstrated an estimated efficacy of 31%, which correlated…”
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Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor by Pegu, Amarendra, Yang, Zhi-yong, Boyington, Jeffrey C, Wu, Lan, Ko, Sung-Youl, Schmidt, Stephen D, McKee, Krisha, Kong, Wing-Pui, Shi, Wei, Chen, Xuejun, Todd, John-Paul, Letvin, Norman L, Huang, Jinghe, Nason, Martha C, Hoxie, James A, Kwong, Peter D, Connors, Mark, Rao, Srinivas S, Mascola, John R, Nabel, Gary J

“…HIV-1 infection depends on effective viral entry mediated by the interaction of its envelope (Env) glycoprotein with specific cell surface receptors…”
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Whole-Genome Association Study of Major Determinants for Host Control of HIV-1 by Fellay, Jacques, Shianna, Kevin V, Ge, Dongliang, Colombo, Sara, Ledergerber, Bruno, Weale, Mike, Zhang, Kunlin, Gumbs, Curtis, Castagna, Antonella, Cossarizza, Andrea, Cozzi-Lepri, Alessandro, De Luca, Andrea, Easterbrook, Philippa, Francioli, Patrick, Mallal, Simon, Martinez-Picado, Javier, Miro, José M, Obel, Niels, Smith, Jason P, Wyniger, Josiane, Descombes, Patrick, Antonarakis, Stylianos E, Letvin, Norman L, McMichael, Andrew J, Haynes, Barton F, Telenti, Amalio, Goldstein, David B

“…Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for…”
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Copy number variation of KIR genes influences HIV-1 control by Pelak, Kimberly, Need, Anna C, Fellay, Jacques, Shianna, Kevin V, Feng, Sheng, Urban, Thomas J, Ge, Dongliang, De Luca, Andrea, Martinez-Picado, Javier, Wolinsky, Steven M, Martinson, Jeremy J, Jamieson, Beth D, Bream, Jay H, Martin, Maureen P, Borrow, Persephone, Letvin, Norman L, McMichael, Andrew J, Haynes, Barton F, Telenti, Amalio, Carrington, Mary, Goldstein, David B, Alter, Galit

“…A genome-wide screen for large structural variants showed that a copy number variant (CNV) in the region encoding killer cell immunoglobulin-like receptors…”
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Correlates of Immune Protection and the Development of a Human Immunodeficiency Virus Vaccine by Letvin, Norman L.

“…Because established vaccine technologies are not likely to provide protection against human immunodeficiency virus (HIV) infection, efforts are being focused…”
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Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1 by Keele, Brandon F, Li, Hui, Learn, Gerald H, Hraber, Peter, Giorgi, Elena E, Grayson, Truman, Sun, Chuanxi, Chen, Yalu, Yeh, Wendy W, Letvin, Norman L, Mascola, John R, Nabel, Gary J, Haynes, Barton F, Bhattacharya, Tanmoy, Perelson, Alan S, Korber, Bette T, Hahn, Beatrice H, Shaw, George M

“…We recently developed a novel strategy to identify transmitted HIV-1 genomes in acutely infected humans using single-genome amplification and a model of random…”
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Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids by Panas, Michael W., Jain, Paras, Yang, Hui, Mitra, Shimontini, Biswas, Debasis, Wattam, Alice Rebecca, Letvin, Norman L., Jacobs, William R.

“…Significance A mutant strain of Mycobacterium smegmatis mc ²155 provided the first plasmid transformation platform for any mycobacteria. It has since been used…”
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Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes by Gillard, Geoffrey O, Bivas-Benita, Maytal, Hovav, Avi-Hai, Grandpre, Lauren E, Panas, Michael W, Seaman, Michael S, Haynes, Barton F, Letvin, Norman L

“…While immunological memory has long been considered the province of T- and B-lymphocytes, it has recently been reported that innate cell populations are…”
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Moving Forward in HIV Vaccine Development by Letvin, Norman L

“…Clinical trial results of a vaccine regimen to prevent HIV infection show modest protection and suggest that changes are needed in the direction of future…”
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A critical role for CD8 T cells in a nonhuman primate model of tuberculosis by Chen, Crystal Y, Huang, Dan, Wang, Richard C, Shen, Ling, Zeng, Gucheng, Yao, Shuyun, Shen, Yun, Halliday, Lisa, Fortman, Jeff, McAllister, Milton, Estep, Jim, Hunt, Robert, Vasconcelos, Daphne, Du, George, Porcelli, Steven A, Larsen, Michelle H, Jacobs, Jr, William R, Haynes, Barton F, Letvin, Norman L, Chen, Zheng W

“…The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell-mediated protection against tuberculosis in mice…”
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Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys by Letvin, Norman L, Rao, Srinivas S, Montefiori, David C, Seaman, Michael S, Sun, Yue, Lim, So-Yon, Yeh, Wendy W, Asmal, Mohammed, Gelman, Rebecca S, Shen, Ling, Whitney, James B, Seoighe, Cathal, Lacerda, Miguel, Keating, Sheila, Norris, Philip J, Hudgens, Michael G, Gilbert, Peter B, Buzby, Adam P, Mach, Linh V, Zhang, Jinrong, Balachandran, Harikrishnan, Shaw, George M, Schmidt, Stephen D, Todd, John-Paul, Dodson, Alan, Mascola, John R, Nabel, Gary J

“…The RV144 vaccine trial in Thailand demonstrated that an HIV vaccine could prevent infection in humans and highlights the importance of understanding…”
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Antigenicity and Immunogenicity of RV144 Vaccine AIDSVAX Clade E Envelope Immunogen Is Enhanced by a gp120 N-Terminal Deletion by Alam, S Munir, Liao, Hua-Xin, Tomaras, Georgia D, Bonsignori, Mattia, Tsao, Chun-Yen, Hwang, Kwan-Ki, Chen, Haiyan, Lloyd, Krissey E, Bowman, Cindy, Sutherland, Laura, Jeffries, Jr, Thomas L, Kozink, Daniel M, Stewart, Shelley, Anasti, Kara, Jaeger, Frederick H, Parks, Robert, Yates, Nicole L, Overman, R Glenn, Sinangil, Faruk, Berman, Phillip W, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Karasavva, Nicos, Rerks-Ngarm, Supachai, Kim, Jerome H, Michael, Nelson L, Zolla-Pazner, Susan, Santra, Sampa, Letvin, Norman L, Harrison, Stephen C, Haynes, Barton F

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Toll-Like Receptor 7/8 (TLR7/8) and TLR9 Agonists Cooperate To Enhance HIV-1 Envelope Antibody Responses in Rhesus Macaques by Moody, M Anthony, Santra, Sampa, Vandergrift, Nathan A, Sutherland, Laura L, Gurley, Thaddeus C, Drinker, Mark S, Allen, Ashley A, Xia, Shi-Mao, Meyerhoff, R Ryan, Parks, Robert, Lloyd, Krissey E, Easterhoff, David, Alam, S Munir, Liao, Hua-Xin, Ward, Brandy M, Ferrari, Guido, Montefiori, David C, Tomaras, Georgia D, Seder, Robert A, Letvin, Norman L, Haynes, Barton F

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Antibody-Dependent Cell-Mediated Cytotoxicity in Simian Immunodeficiency Virus-Infected Rhesus Monkeys by YUE SUN, ASMAL, Mohammed, LANE, Sophie, PERMAR, Sallie R, SCHMIDT, Stephen D, MASCOLA, John R, LETVIN, Norman L

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Low-Dose Mucosal Simian Immunodeficiency Virus Infection Restricts Early Replication Kinetics and Transmitted Virus Variants in Rhesus Monkeys by JINYAN LIU, KEELE, Brandon F, LETVIN, Norman L, HAHN, Beatrice H, SHAW, George M, BAROUCH, Dan H, HUI LI, KEATING, Sheila, NORRIS, Philip J, CARVILLE, Angela, MANSFIELD, Keith G, TOMARAS, Georgia D, HAYNES, Barton F, KOLODKIN-GAL, Dror

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Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates by Saunders, Kevin O., Nicely, Nathan I., Wiehe, Kevin, Bonsignori, Mattia, Meyerhoff, R. Ryan, Parks, Robert, Walkowicz, William E., Aussedat, Baptiste, Wu, Nelson R., Cai, Fangping, Vohra, Yusuf, Park, Peter K., Eaton, Amanda, Go, Eden P., Sutherland, Laura L., Scearce, Richard M., Barouch, Dan H., Zhang, Ruijun, Von Holle, Tarra, Overman, R. Glenn, Anasti, Kara, Sanders, Rogier W., Moody, M. Anthony, Kepler, Thomas B., Korber, Bette, Desaire, Heather, Santra, Sampa, Letvin, Norman L., Nabel, Gary J., Montefiori, David C., Tomaras, Georgia D., Liao, Hua-Xin, Alam, S. Munir, Danishefsky, Samuel J., Haynes, Barton F.

“…Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third…”
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Efficiency of Cell-Free and Cell-Associated Virus in Mucosal Transmission of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus by Kolodkin-Gal, Dror, Hulot, Sandrine L, Korioth-Schmitz, Birgit, Gombos, Randi B, Zheng, Yi, Owuor, Joshua, Lifton, Michelle A, Ayeni, Christian, Najarian, Robert M, Yeh, Wendy W, Asmal, Mohammed, Zamir, Gideon, Letvin, Norman L

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Effect of Preexisting Immunity to Adenovirus Human Serotype 5 Antigens on the Immune Responses of Nonhuman Primates to Vaccine Regimens Based on Human- or Chimpanzee-Derived Adenovirus Vectors by McCoy, Kimberly, Tatsis, Nia, Korioth-Schmitz, Birgit, Lasaro, Marcio O, Hensley, Scott E, Lin, Shih-Wen, Li, Yan, Giles-Davis, Wynetta, Cun, Ann, Zhou, Dongming, Xiang, Zhiquan, Letvin, Norman L, Ertl, Hildegund C J

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Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies by Ma, Ben-Jiang, Alam, S Munir, Go, Eden P, Lu, Xiaozhi, Desaire, Heather, Tomaras, Georgia D, Bowman, Cindy, Sutherland, Laura L, Scearce, Richard M, Santra, Sampa, Letvin, Norman L, Kepler, Thomas B, Liao, Hua-Xin, Haynes, Barton F

“…The HIV-1 gp41 envelope (Env) membrane proximal external region (MPER) is an important vaccine target that in rare subjects can elicit neutralizing antibodies…”
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