Search Results - "Letterio, J J"

LOCC: a novel visualization and scoring of cutoffs for continuous variables with hepatocellular carcinoma prognosis as an example by Luo, George, Chen, Toby, Letterio, John J

“…The interpretation of large datasets, such as The Cancer Genome Atlas (TCGA), for scientific and research purposes, remains challenging despite their public…”
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Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity by Dorand, R. Dixon, Nthale, Joseph, Myers, Jay T., Barkauskas, Deborah S., Avril, Stefanie, Chirieleison, Steven M., Pareek, Tej K., Abbott, Derek W., Stearns, Duncan S., Letterio, John J., Huang, Alex Y., Petrosiute, Agne

“…Cancers often evade immune surveillance by adopting peripheral tissue–tolerance mechanisms, such as the expression of programmed cell death ligand 1 (PD-L1),…”
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Estimating the prevalence and risk of COVID-19 among international travelers and evacuees of Wuhan through modeling and case reports by Luo, George, McHenry, Michael L, Letterio, John J

“…Coronavirus disease 2019 (COVID-19) started in Wuhan, China and has spread through other provinces and countries through infected travelers. On January 23rd,…”
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Alex's Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011 by Ostrom, Quinn T, de Blank, Peter M, Kruchko, Carol, Petersen, Claire M, Liao, Peter, Finlay, Jonathan L, Stearns, Duncan S, Wolff, Johannes E, Wolinsky, Yingli, Letterio, John J, Barnholtz-Sloan, Jill S

“…The CBTRUS Statistical Report: Alex's Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United…”
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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response by Roberts, Anita B, Ashcroft, Gillian S, Yang, Xiao, Glick, Adam B, Weinstein, Michael, Letterio, John J, Mizel, Diane E, Anzano, Mario, Greenwell-Wild, Teresa, Wahl, Sharon M, Deng, Chuxia

“…The generation of animals lacking SMAD proteins, which transduce signals from transforming growth factor-beta (TGF-beta), has made it possible to explore the…”
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REGULATION OF IMMUNE RESPONSES BY TGF-β by Letterio, John J, Roberts, Anita B

“…The transforming growth factor β (TGF-β) family of proteins are a set of pleiotropic secreted signaling molecules with unique and potent immunoregulatory…”
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Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase by Choi, Sung Hee, Huang, Alex Y., Letterio, John J., Kim, Byung-Gyu

“…Immune cells and the cytokines they produce are important mediators of the transition from colitis to colon cancer, but the mechanisms mediating this disease…”
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The synthetic oleanane triterpenoid CDDO‐2P‐Im binds GRP78/BiP to induce unfolded protein response‐mediated apoptosis in myeloma by Luo, George, Aldridge, Kristin, Chen, Toby, Aslot, Vivek, Kim, Byung‐Gyu, Han, Eun Hyang, Singh, Neelima, Li, Sai, Xiao, Tsan Sam, Sporn, Michael B., Letterio, John J.

“…Synthetic oleanane triterpenoids (SOTs) are small molecules with broad anticancer properties. A recently developed SOT,…”
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Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence by Terabe, Masaki, Matsui, So, Park, Jong-Myun, Mamura, Mizuko, Noben-Trauth, Nancy, Donaldson, Debra D, Chen, Wanjun, Wahl, Sharon M, Ledbetter, Steven, Pratt, Bruce, Letterio, John J, Paul, William E, Berzofsky, Jay A

“…Our previous work demonstrated that cytotoxic T lymphocyte (CTL)-mediated tumor immunosurveillance of the 15-12RM tumor could be suppressed by a…”
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Overexpression of VEGF in the MOPC 315 Plasmacytoma Induces Tumor Immunity in Mice by Kim, Byung-Gyu, Choi, Sung Hee, Letterio, John J, Song, Jie-Young, Huang, Alex Y

“…Vascular endothelial growth factor (VEGF) has important effects on hematopoietic and immune cells. A link between VEGF expression, tumor progression, and…”
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TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia by Letterio, John J

“…Transforming growth factor-beta (TGF-beta) plays an essential role in regulating the homeostasis of cells in the lymphoid lineage. TGF-beta signaling is not…”
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Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis by Pareek, Tej K., Belkadi, Abdelmadjid, Kesavapany, Sashi, Zaremba, Anita, Loh, Sook L., Bai, Lianhua, Cohen, Mark L., Meyer, Colin, Liby, Karen T., Miller, Robert H., Sporn, Michael B., Letterio, John J.

“…Inflammatory cytokines and endogenous anti-oxidants are variables affecting disease progression in multiple sclerosis (MS). Here we demonstrate the dual…”
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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β by Yang, Xiao, Letterio, John J., Lechleider, Robert J., Chen, Lin, Hayman, Russ, Gu, Hua, Roberts, Anita B., Deng, Chuxia

“…SMAD3 is one of the intracellular mediators that transduces signals from transforming growth factor‐β (TGF‐β) and activin receptors. We show that SMAD3 mutant…”
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IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent by Kaviratne, Mallika, Hesse, Matthias, Leusink, Mary, Cheever, Allen W, Davies, Stephen J, McKerrow, James H, Wakefield, Lalage M, Letterio, John J, Wynn, Thomas A

“…Fibrosis is a characteristic feature in the pathogenesis of a wide spectrum of diseases. Recently, it was suggested that IL-13-dependent fibrosis develops…”
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Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4 by Choi, Sung Hee, Barker, Emily C., Gerber, Kyle J., Letterio, John J., Kim, Byung-Gyu

“…The cyclin-dependent kinase inhibitor p27 Kip1 is a tumor suppressor whose intrinsic activity in cancer cells correlates with tumor aggressiveness,…”
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The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells by LIBY, Karen, VOONG, Nga, WILLIAMS, Charlotte R, RISINGSONG, Renee, ROYCE, Darlene B, HONDA, Tadashi, GRIBBLE, Gordon W, SPORN, Michael B, LETTERIO, John J

“…Purpose: Excessive activity of the transcription factors known as signal transducers and activators of transcription (STAT) contributes to the development and…”
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Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma by Lin, Ying-Wei, Nichols, Rebecca A., Letterio, John J., Aplan, Peter D.

“…NOTCH1 is frequently mutated in human precursor T-cell lymphoblastic leukemia/lymphoma (pre-T LBL). In the current study, we found that 13 of 19 cell lines and…”
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Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis by Kullberg, Marika C, Jankovic, Dragana, Gorelick, Peter L, Caspar, Patricia, Letterio, John J, Cheever, Allen W, Sher, Alan

“…We have previously demonstrated that interleukin (IL)-10-deficient (IL-10 knockout [KO]) but not wild-type (WT) mice develop colitis after infection with…”
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Loss of Smad3 in Acute T-Cell Lymphoblastic Leukemia by Wolfraim, Lawrence A, Fernandez, Tania M, Mamura, Mizuko, Fuller, Walter L, Kumar, Rajesh, Cole, Diane E, Byfield, Stacey, Felici, Angelina, Flanders, Kathleen C, Walz, Thomas M, Roberts, Anita B, Aplan, Peter D, Balis, Frank M, Letterio, John J

“…Smad3 is a signaling molecule that has a key role in the cascade evoked by the binding of transforming growth factor β, a tumor suppressor, to its receptor on…”
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Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects by Yang, Yu-An, Dukhanina, Oksana, Tang, Binwu, Mamura, Mizuko, Letterio, John J, MacGregor, Jennifer, Patel, Sejal C, Khozin, Shahram, Liu, Zi-Yao, Green, Jeffrey, Anver, Miriam R, Merlino, Glenn, Wakefield, Lalage M

“…TGF-betas play diverse and complex roles in many biological processes. In tumorigenesis, they can function either as tumor suppressors or as pro-oncogenic…”
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