Search Results - "Lettau, Marcus"

Intra- and Extracellular Effector Vesicles From Human T And NK Cells: Same-Same, but Different? by Lettau, Marcus, Janssen, Ottmar

“…Cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells utilize an overlapping effector arsenal for the elimination of target cells. It was initially…”
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Shedding of endogenous MHC class I‐related chain molecules A and B from different human tumor entities: Heterogeneous involvement of the “a disintegrin and metalloproteases” 10 and 17 by Chitadze, Guranda, Lettau, Marcus, Bhat, Jaydeep, Wesch, Daniela, Steinle, Alexander, Fürst, Daniel, Mytilineos, Joannis, Kalthoff, Holger, Janssen, Ottmar, Oberg, Hans‐Heinrich, Kabelitz, Dieter

“…The interaction of the MHC class I‐related chain molecules A and B (MICA and MICB) with the corresponding natural killer group 2, member D (NKG2D) receptor…”
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Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells by Serrano, Ruben, Lettau, Marcus, Zarobkiewicz, Michal, Wesch, Daniela, Peters, Christian, Kabelitz, Dieter

“…Ligands for Stimulator of Interferon Genes (STING) receptor are under investigation as adjuvants in cancer therapy. Multiple effects have been described,…”
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Degranulation of human cytotoxic lymphocytes is a major source of proteolytically active soluble CD26/DPP4 by Lettau, Marcus, Dietz, Michelle, Vollmers, Sarah, Armbrust, Fred, Peters, Christian, Dang, Thi Mai, Chitadze, Guranda, Kabelitz, Dieter, Janssen, Ottmar

“…Dipeptidyl peptidase 4 (DPP4, CD26) is a serine protease detected on several immune cells and on epithelial cells of various organs. Besides the membrane-bound…”
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Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10) by Ebsen, Henriette, Lettau, Marcus, Kabelitz, Dieter, Janssen, Ottmar

“…The a disintegrin and metalloproteases (ADAMs) play a pivotal role in the control of development, adhesion, migration, inflammation and cancer. Although…”
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Comparative Analysis of Extracellular Vesicles from Cytotoxic CD8 + αβ T Cells and γδ T Cells by Griesel, Lisa, Kaleja, Patrick, Tholey, Andreas, Lettau, Marcus, Janssen, Ottmar

“…Although belonging to different branches of the immune system, cytotoxic CD8 αβ T cells and γδ T cells utilize common cytolytic effectors including FasL,…”
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Analysis of Cytotoxic Granules and Constitutively Produced Extracellular Vesicles from Large Granular Lymphocytic Leukemia Cell Lines by Ploeger, Lara, Kaleja, Patrick, Tholey, Andreas, Lettau, Marcus, Janssen, Ottmar

“…Large granular lymphocyte leukemias (LGLLs) are rare lymphoproliferative malignancies caused by clonal expansion of granular lymphocytes. T-cell LGLL and…”
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TGF-β enhances the cytotoxic activity of Vδ2 T cells by Peters, Christian, Meyer, Annika, Kouakanou, Léonce, Feder, Julia, Schricker, Tim, Lettau, Marcus, Janssen, Ottmar, Wesch, Daniela, Kabelitz, Dieter

“…TGF-β is a pleiotropic cytokine with multiple roles in immunity. Apart from its suppressive activity, TGF-β is a driving cytokine in the differentiation of…”
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Chitosan nanoparticles as antigen vehicles to induce effective tumor specific T cell responses by Walter, Frederik, Winter, Elsa, Rahn, Sascha, Heidland, Judith, Meier, Saskia, Struzek, Anna-Maria, Lettau, Marcus, Philipp, Lisa-Marie, Beckinger, Silje, Otto, Lilli, Möller, Julia Luisa, Helm, Ole, Wesch, Daniela, Scherließ, Regina, Sebens, Susanne

“…Cancer vaccinations sensitize the immune system to recognize tumor-specific antigens de novo or boosting preexisting immune responses. Dendritic cells (DCs)…”
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Galectin-3 Released by Pancreatic Ductal Adenocarcinoma Suppresses γδ T Cell Proliferation but Not Their Cytotoxicity by Gonnermann, Daniel, Oberg, Hans-Heinrich, Lettau, Marcus, Peipp, Matthias, Bauerschlag, Dirk, Sebens, Susanne, Kabelitz, Dieter, Wesch, Daniela

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment with a dense desmoplastic stroma. The expression of…”
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Immunosurveillance by human γδ T lymphocytes: the emerging role of butyrophilins [version 1; peer review: 2 approved] by Kabelitz, Dieter, Lettau, Marcus, Janssen, Ottmar

“…In contrast to conventional T lymphocytes, which carry an αβ T-cell receptor and recognize antigens as peptides presented by major histocompatibility complex…”
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Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells by Lettau, Marcus, Armbrust, Fred, Dohmen, Katharina, Drews, Lisann, Poch, Tobias, Dietz, Michelle, Kabelitz, Dieter, Janssen, Ottmar

“…Abstract It is widely accepted that cytotoxic T and NK cells store effector proteins including granzymes, perforin and Fas ligand (FasL) in intracellular…”
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Histone Deacetylase Inhibitor Modulates NKG2D Receptor Expression and Memory Phenotype of Human Gamma/Delta T Cells Upon Interaction With Tumor Cells by Bhat, Jaydeep, Dubin, Samuel, Dananberg, Alexandra, Quabius, Elgar Susanne, Fritsch, Juergen, Dowds, C Marie, Saxena, Ankit, Chitadze, Guranda, Lettau, Marcus, Kabelitz, Dieter

“…The functional plasticity and anti-tumor potential of human γδ T cells have been widely studied. However, the epigenetic regulation of γδ T-cell/tumor cell…”
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NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors by Chitadze, Guranda, Lettau, Marcus, Luecke, Stefanie, Wang, Ting, Janssen, Ottmar, Fürst, Daniel, Mytilineos, Joannis, Wesch, Daniela, Oberg, Hans-Heinrich, Held-Feindt, Janka, Kabelitz, Dieter

“…The interaction of the MHC class I-related chain molecules A and B (MICA and MICB) and UL-16 binding protein (ULBP) family members expressed on tumor cells…”
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In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment by Chitadze, Guranda, Flüh, Charlotte, Quabius, Elgar Susanne, Freitag-Wolf, Sandra, Peters, Christian, Lettau, Marcus, Bhat, Jaydeep, Wesch, Daniela, Oberg, Hans-Heinrich, Luecke, Stefanie, Janssen, Ottmar, Synowitz, Michael, Held-Feindt, Janka, Kabelitz, Dieter

“…Despite aggressive treatment regimens based on surgery and radiochemotherapy, the prognosis of patients with grade IV glioblastoma multiforme (GBM) remains…”
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Nck adapter proteins: functional versatility in T cells by Lettau, Marcus, Pieper, Jennifer, Janssen, Ottmar

“…Nck is a ubiquitously expressed adapter protein that is almost exclusively built of one SH2 domain and three SH3 domains. The two isoproteins of Nck are…”
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Storage, expression and function of Fas ligand, the key death factor of immune cells by Lettau, Marcus, Paulsen, Maren, Kabelitz, Dieter, Janssen, Ottmar

“…The TNF family member Fas ligand (FasL) induces apoptosis in Fas-expressing cells and serves as a key death factor in the immune system. It is involved in the…”
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Stromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells through Lyn-driven extracellular vesicles by de Oliveira, Thaís Dolzany, Vom Stein, Alexander, Rebollido-Rios, Rocio, Lobastova, Liudmila, Lettau, Marcus, Janssen, Ottmar, Wagle, Prerana, Nguyen, Phuong-Hien, Hallek, Michael, Hansen, Hinrich P

“…In chronic lymphocytic leukemia (CLL), the tumor cells receive survival support from stromal cells through direct cell contact, soluble factors and…”
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Dominant T‐cell Receptor Delta Rearrangements in B‐cell Precursor Acute Lymphoblastic Leukemia: Leukemic Markers or Physiological γδ T Repertoire? by Kelm, Miriam, Darzentas, Franziska, Darzentas, Nikos, Kotrova, Michaela, Wessels, Wiebke, Bendig, Sonja, Baldus, Claudia D., Lettau, Marcus, Gökbuget, Nicola, Kabelitz, Dieter, Brüggemann, Monika, Chitadze, Guranda

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Chemotherapy‐induced release of ADAM17 bearing EV as a potential resistance mechanism in ovarian cancer by Hugendieck, Gerrit, Lettau, Marcus, Andreas, Svenja, Neumann, Sabrina, Reinhardt, Natalie, Arnold, Philipp, Theilig, Franziska, Bastian, Lorenz, Rogmans, Christoph, Weimer, Jörg P., Flörkemeier, Inken, Wesch, Daniela, Arnold, Norbert, Maass, Nicolai, Janssen, Ottmar, Bauerschlag, Dirk, Hedemann, Nina

“…Ovarian cancer (OvCa) is the gynaecological disorder with the poorest prognosis due to the fast development of chemoresistance. We sought to connect…”
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