Search Results - "Letko, Michael"

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses by Letko, Michael, Marzi, Andrea, Munster, Vincent

“…Over the past 20 years, several coronaviruses have crossed the species barrier into humans, causing outbreaks of severe, and often fatal, respiratory illness…”
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An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines by Seifert, Stephanie N, Bai, Shuangyi, Fawcett, Stephen, Norton, Elizabeth B, Zwezdaryk, Kevin J, Robinson, James, Gunn, Bronwyn, Letko, Michael

“…Spillover of sarbecoviruses from animals to humans has resulted in outbreaks of severe acute respiratory syndrome SARS-CoVs and the ongoing COVID-19 pandemic…”
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The Structural Interface between HIV-1 Vif and Human APOBEC3H by Ooms, Marcel, Letko, Michael, Simon, Viviana

“…Human APOBEC3H (A3H) is a cytidine deaminase that inhibits HIV-1 replication. To evade this restriction, the HIV-1 Vif protein binds A3H and mediates its…”
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Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection by Rosenke, Kyle, Meade-White, Kimberly, Letko, Michael, Clancy, Chad, Hansen, Frederick, Liu, Yanan, Okumura, Atsushi, Tang-Huau, Tsing-Lee, Li, Rong, Saturday, Greg, Feldmann, Friederike, Scott, Dana, Wang, Zhongde, Munster, Vincent, Jarvis, Michael A., Feldmann, Heinz

“…Following emergence in late 2019, SARS-CoV-2 rapidly became pandemic and is presently responsible for millions of infections and hundreds of thousands of…”
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Adaptive Evolution of MERS-CoV to Species Variation in DPP4 by Letko, Michael, Miazgowicz, Kerri, McMinn, Rebekah, Seifert, Stephanie N., Sola, Isabel, Enjuanes, Luis, Carmody, Aaron, van Doremalen, Neeltje, Munster, Vincent

“…Middle East Respiratory Syndrome Coronavirus (MERS-CoV) likely originated in bats and passed to humans through dromedary camels; however, the genetic…”
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Identification of the HIV-1 Vif and Human APOBEC3G Protein Interface by Letko, Michael, Booiman, Thijs, Kootstra, Neeltje, Simon, Viviana, Ooms, Marcel

“…Human cells express natural antiviral proteins, such as APOBEC3G (A3G), that potently restrict HIV replication. As a counter-defense, HIV encodes the accessory…”
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The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint by Guo, Hua, Li, Ang, Lin, Hao-Feng, Liu, Mei-Qin, Chen, Jing, Jiang, Ting-Ting, Li, Bei, Wang, Yi, Letko, Michael C, Peng, Wenjie, Shi, Zheng-Li

“…The spike protein on sarbecovirus virions contains two external, protruding domains: an N-terminal domain (NTD) with unclear function and a C-terminal domain…”
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Origin of the HIV-1 group O epidemic in western lowland gorillas by D’arc, Mirela, Ayouba, Ahidjo, Esteban, Amandine, Learn, Gerald H., Boué, Vanina, Liegeois, Florian, Etienne, Lucie, Tagg, Nikki, Leendertz, Fabian H., Boesch, Christophe, Madinda, Nadège F., Robbins, Martha M., Gray, Maryke, Cournil, Amandine, Ooms, Marcel, Letko, Michael, Simon, Viviana A., Sharp, Paul M., Hahn, Beatrice H., Delaporte, Eric, Ngole, Eitel Mpoudi, Peeters, Martine

“…Significance Understanding emerging disease origins is important to gauge future human infection risks. This is particularly true for the various forms of the…”
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A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters by van Doremalen, Neeltje, Lambe, Teresa, Sebastian, Sarah, Bushmaker, Trenton, Fischer, Robert, Feldmann, Friederike, Haddock, Elaine, Letko, Michael, Avanzato, Victoria A, Rissanen, Ilona, LaCasse, Rachel, Scott, Dana, Bowden, Thomas A, Gilbert, Sarah, Munster, Vincent

“…Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals…”
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The resistance of human APOBEC3H to HIV-1 NL4-3 molecular clone is determined by a single amino acid in Vif by Ooms, Marcel, Letko, Michael, Binka, Mawuena, Simon, Viviana

“…Some human APOBEC3 cytidine deaminases have antiviral activity against HIV-1 and other retroviruses. The single deaminase domain APOBEC3H (A3H) enzyme is…”
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Sequence determinants of human-cell entry identified in ACE2-independent bat sarbecoviruses: A combined laboratory and computational network science approach by Khaledian, Ehdieh, Ulusan, Sinem, Erickson, Jeffery, Fawcett, Stephen, Letko, Michael C., Broschat, Shira L.

“…The sarbecovirus subgenus of betacoronaviruses is widely distributed throughout bats and other mammals globally and includes human pathogens, SARS-CoV and…”
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Rousettus aegyptiacus Bats Do Not Support Productive Nipah Virus Replication by Seifert, Stephanie N, Letko, Michael C, Bushmaker, Trenton, Laing, Eric D, Saturday, Greg, Meade-White, Kimberly, van Doremalen, Neeltje, Broder, Christopher C, Munster, Vincent J

“…Abstract Nipah virus (NiV) is a bat-borne zoonotic pathogen that can cause severe respiratory distress and encephalitis upon spillover into humans. NiV is…”
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ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells by Guo, Hua, Li, Ang, Dong, Tian-Yi, Su, Jia, Yao, Yu-Lin, Zhu, Yan, Shi, Zheng-Li, Letko, Michael

“…Hundreds of sarbecoviruses have been found in bats, but only a fraction of them have the ability to infect cells using angiotensin-converting enzyme 2 (ACE2),…”
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HIV-1 Vif Adaptation to Human APOBEC3H Haplotypes by Ooms, Marcel, Brayton, Bonnie, Letko, Michael, Maio, Susan M., Pilcher, Christopher D., Hecht, Frederick M., Barbour, Jason D., Simon, Viviana

“…Several human APOBEC3 deaminases can inhibit HIV-1 replication in vitro. HIV-1 Vif counteracts this restriction by targeting APOBEC3 for proteasomal…”
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Serological Evidence for Henipa-like and Filo-like Viruses in Trinidad Bats by Schulz, Jonathan E, Seifert, Stephanie N, Thompson, John T, Avanzato, Victoria, Sterling, Spencer L, Yan, Lianying, Letko, Michael C, Matson, M Jeremiah, Fischer, Robert J, Tremeau-Bravard, Alexandre, Seetahal, Janine F R, Ramkissoon, Vernie, Foster, Jerome, Goldstein, Tracey, Anthony, Simon J, Epstein, Jonathan H, Laing, Eric D, Broder, Christopher C, Carrington, Christine V F, Schountz, Tony, Munster, Vincent J

“…Abstract Bat-borne zoonotic pathogens belonging to the family Paramxyoviridae, including Nipah and Hendra viruses, and the family Filoviridae, including Ebola…”
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Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Camel Populations, Southern Jordan, 2014-2018 by Holloway, Peter, Gibson, Matthew, van Doremalen, Neeltje, Nash, Stephen, Holloway, Tanja, Letko, Michael, Cardwell, Jacqueline M, Al Omari, Bilal, Al-Majali, Ahmad, Abu-Basha, Ehab, Mangtani, Punam, Munster, Vincent J, Guitian, Javier

“…After the first detection of Middle East respiratory syndrome coronavirus (MERS-CoV) in camels in Jordan in 2013, we conducted 2 consecutive surveys in…”
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Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study by Lombardi, Andrea, Butta, Giacomo M., Donnici, Lorena, Bozzi, Giorgio, Oggioni, Massimo, Bono, Patrizia, Matera, Malvina, Consonni, Dario, Ludovisi, Serena, Muscatello, Antonio, Ceriotti, Ferruccio, Conti, Matteo, Scaglioni, Susanna, Gallo, Greta, Scarpa, Edoardo, Letko, Michael, Abrignani, Sergio, Grifantini, Renata, De Francesco, Raffaele, Gori, Andrea, Manganaro, Lara, Bandera, Alessandra

“…Vaccines against COVID-19 are a powerful tool to control the current SARS-CoV-2 pandemic. A thorough description of their immunogenicity among people living…”
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Vif Proteins from Diverse Primate Lentiviral Lineages Use the Same Binding Site in APOBEC3G by Letko, Michael, Silvestri, Guido, Hahn, Beatrice H, Bibollet-Ruche, Frederick, Gokcumen, Omer, Simon, Viviana, Ooms, Marcel

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018 by van Doremalen, Neeltje, Letko, Michael, Fischer, Robert J, Bushmaker, Trenton, Schulz, Jonathan, Yinda, Claude K, Seifert, Stephanie N, Kim, Nam Joong, Hemida, Maged G, Kayali, Ghazi, Park, Wan Beom, Perera, Ranawaka A P M, Tamin, Azaibi, Thornburg, Natalie J, Tong, Suxiang, Queen, Krista, van Kerkhove, Maria D, Choi, Young Ki, Oh, Myoung-Don, Assiri, Abdullah M, Peiris, Malik, Gerber, Susan I, Munster, Vincent J

“…Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans and dromedary camels and is responsible for an ongoing outbreak of severe respiratory…”
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APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host by Krupp, Annabel, McCarthy, Kevin R, Ooms, Marcel, Letko, Michael, Morgan, Jennifer S, Simon, Viviana, Johnson, Welkin E

“…Cellular restriction factors, which render cells intrinsically resistant to viruses, potentially impose genetic barriers to cross-species transmission and…”
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