Search Results - "Lesty, Claude"
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Sex chromosome loss may represent a disease-associated clonal population in chronic lymphocytic leukemia
Published in Genes chromosomes & cancer (01-03-2014)“…Whether sex chromosome loss (SCL) is an age‐related phenomenon or a cytogenetic marker of hematological disease is unclear. To address this issue in chronic…”
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Dynamic Changes of Fibrin Architecture during Fibrin Formation and Intrinsic Fibrinolysis of Fibrin-rich Clots
Published in The Journal of biological chemistry (13-06-2003)“…Clotting and fibrinolysis are initiated simultaneously in vivo, and fibrinolysis usually occurs without any individualized lysis front (intrinsic…”
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3
Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages
Published in Leukemia research (01-01-2010)“…Abstract Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change…”
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4
Abnormal fibrin clot architecture in nephrotic patients is related to hypofibrinolysis: influence of plasma biochemical modifications: a possible mechanism for the high thrombotic tendency?
Published in Thrombosis and haemostasis (01-11-1999)“…Porosity, viscoelasticity and morphological properties of plasma fibrin from 16 nephrotic patients and 16 healthy volunteers were compared. Nephrotic patients…”
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5
Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53
Published in Blood (21-11-2019)“…B-cell prolymphocytic leukemia (B-PLL) is a rare hematological disorder whose underlying oncogenic mechanisms are poorly understood. Our cytogenetic and…”
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6
EGFR expression in pancreatic adenocarcinoma. Relationship to tumour morphology and cell adhesion proteins
Published in Journal of clinical pathology (01-04-2014)“…We aimed to study epidermal growth factor receptor (EGFR) expression in surgically resected pancreatic ductal adenocarcinomas (PDACs) by immunohistochemistry…”
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7
Mutational and cytogenetic analyses of 188 CLL patients with trisomy 12: A retrospective study from the French Innovative Leukemia Organization (FILO) working group
Published in Genes chromosomes & cancer (01-11-2018)“…Trisomy 12 (tri12) is the second most frequent chromosomal aberration (15%‐20%) in chronic lymphocytic leukemia (CLL). Tri12 confers an intermediate prognosis…”
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8
Primary vitreoretinal lymphomas display a remarkably restricted immunoglobulin gene repertoire
Published in Blood advances (14-04-2020)“…Primary vitreoretinal lymphoma (PVRL) is a high-grade lymphoma affecting the vitreous and/or the retina. The vast majority of cases are histopathologically…”
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Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53
Published in Blood (16-09-2019)“…Key Points B-PLL is tightly linked to MYC aberrations (translocation or gain) and 17p (TP53) deletion. Cases of B-PLL with MYC aberration and 17p (TP53)…”
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10
Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53
Published in Blood (16-09-2019)“…Key Points B-PLL is tightly linked to MYC aberrations (translocation or gain) and 17p (TP53) deletion. Cases of B-PLL with MYC aberration and 17p (TP53)…”
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11
Targeted Sequencing for Clinical Investigation in Chronic Lymphocytic Leukemia
Published in Blood (02-12-2016)“…Introduction Next generation sequencing (NGS) studies have documented the highly heterogeneous landscape of somatic mutations in CLL. Beside the mere genetic…”
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Genetic Characterization of B-Cell Prolymphocytic Leukemia (B-PLL): A Hierarchical Prognostic Model Involving MYC and TP53 Abnormalities. on Behalf of the Groupe Francophone De Cytogenetique Hematologique (GFCH) and the French Innovative Leukemia Organization (FILO) Group
Published in Blood (29-11-2018)“…B-PLL is defined by the presence of prolymphocytes in peripheral blood exceeding 55% of lymphoid cells. The diagnosis, mainly based on clinical and…”
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13
“Double‐hit” chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain
Published in American journal of hematology (01-03-2018)“…Chronic lymphocytic leukemia (CLL) with 17p deletion (17p‐) is associated with a lack of response to standard treatment and thus the worst possible clinical…”
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14
Auto-Immune Origin of B Cells from HCV-Associated Lymphoma
Published in Blood (03-12-2015)“…Hepatitis C virus (HCV) infection is a well-established risk factor for the development of B cell non-Hodgkin lymphoma (B-NHL). Two main pathways have been…”
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“Double-hit” chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain
Published in American journal of hematology (01-03-2018)Get full text
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Biological and prognostic relevance of mitogen-activated protein kinases in pancreatic adenocarcinoma
Published in Pancreas (01-04-2012)“…The aims of this study were to study the biological and clinical significance of 3 main proteins of the mitogen-activated protein kinase (MAPK) signaling…”
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14q deletions are associated with trisomy 12, NOTCH1 mutations and unmutated IGHV genes in chronic lymphocytic leukemia and small lymphocytic lymphoma
Published in Genes chromosomes & cancer (01-08-2014)“…Deletions of the long arm of chromosome 14 [del(14q)] are rare but recurrently observed in mature B‐cell neoplasms, particularly in chronic lymphocytic…”
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The Gain of the Short Arm of Chromosome 2 (2p+) Induces XPO1 Overexpression and Drug Resistance in Chronic Lymphocytic Leukemia
Published in Blood (03-12-2015)“…Introduction: CLL is a heterogeneous disease in terms of response to treatment, with some patients reaching complete and prolonged remissions, while others…”
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Impact of anticoagulation on ionic and nonionic contrast media effect on thrombogenesis and fibrinolysis: The PEPCIT study
Published in Catheterization and cardiovascular interventions (01-04-2012)“…Objectives: The effect of ionic low osmolar contrast media (ICM) and nonionic iso‐osmolar CM (NICM) on acute thrombotic complications of percutaneous coronary…”
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P27, SKP2, and extra-cellular signal-related kinase signalling in human salivary gland mucoepidermoid carcinoma
Published in Oral oncology (01-11-2006)“…Extra-cellular signal-related kinase (ERK) can modulate P27 in several ways. ERK is phosphorylated in a subset of salivary gland mucoepidermoid carcinoma…”
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