Search Results - "Lester Kirchner, H."

Prediction of mortality from 12-lead electrocardiogram voltage data using a deep neural network by Raghunath, Sushravya, Ulloa Cerna, Alvaro E., Jing, Linyuan, vanMaanen, David P., Stough, Joshua, Hartzel, Dustin N., Leader, Joseph B., Kirchner, H. Lester, Stumpe, Martin C., Hafez, Ashraf, Nemani, Arun, Carbonati, Tanner, Johnson, Kipp W., Young, Katelyn, Good, Christopher W., Pfeifer, John M., Patel, Aalpen A., Delisle, Brian P., Alsaid, Amro, Beer, Dominik, Haggerty, Christopher M., Fornwalt, Brandon K.

“…The electrocardiogram (ECG) is a widely used medical test, consisting of voltage versus time traces collected from surface recordings over the heart 1 . Here…”
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Genetic identification of familial hypercholesterolemia within a single U.S. health care system by Abul-Husn, Noura S., Manickam, Kandamurugu, Jones, Laney K., Wright, Eric A., Hartzel, Dustin N., Gonzaga-Jauregui, Claudia, O'Dushlaine, Colm, Leader, Joseph B., Kirchner, H. Lester, Lindbuchler, D'Andra M., Barr, Marci L., Giovanni, Monica A., Ritchie, Marylyn D., Overton, John D., Reid, Jeffrey G., Metpally, Raghu P. R., Wardeh, Amr H., Borecki, Ingrid B., Yancopoulos, George D., Baras, Aris, Shuldiner, Alan R., Gottesman, Omri, Ledbetter, David H., Carey, David J., Dewey, Frederick E., Murray, Michael F.

“…Familial hypercholesterolemia (FH) remains underdiagnosed despite widespread cholesterol screening. Exome sequencing and electronic health record (EHR) data of…”
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Patient assessment of chatbots for the scalable delivery of genetic counseling by Schmidlen, Tara, Schwartz, Marci, DiLoreto, Kristy, Kirchner, H. Lester, Sturm, Amy C.

“…A barrier to incorporating genomics more broadly is limited access to providers with genomics expertise. Chatbots are a technology‐based simulated conversation…”
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Deep Neural Networks Can Predict New-Onset Atrial Fibrillation From the 12-Lead ECG and Help Identify Those at Risk of Atrial Fibrillation–Related Stroke by Raghunath, Sushravya, Pfeifer, John M., Ulloa-Cerna, Alvaro E., Nemani, Arun, Carbonati, Tanner, Jing, Linyuan, vanMaanen, David P., Hartzel, Dustin N., Ruhl, Jeffery A., Lagerman, Braxton F., Rocha, Daniel B., Stoudt, Nathan J., Schneider, Gargi, Johnson, Kipp W., Zimmerman, Noah, Leader, Joseph B., Kirchner, H. Lester, Griessenauer, Christoph J., Hafez, Ashraf, Good, Christopher W., Fornwalt, Brandon K., Haggerty, Christopher M.

“…Atrial fibrillation (AF) is associated with substantial morbidity, especially when it goes undetected. If new-onset AF could be predicted, targeted screening…”
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Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR Study by Dewey, Frederick E.

“…The DiscovEHR collaboration between the Regeneron Genetics Center and Geisinger Health System couples high-throughput sequencing to an integrated health care…”
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Routinely reported ejection fraction and mortality in clinical practice: where does the nadir of risk lie? by Wehner, Gregory J, Jing, Linyuan, Haggerty, Christopher M, Suever, Jonathan D, Leader, Joseph B, Hartzel, Dustin N, Kirchner, H Lester, Manus, Joseph N A, James, Nick, Ayar, Zina, Gladding, Patrick, Good, Christopher W, Cleland, John G F, Fornwalt, Brandon K

“…Abstract Aims We investigated the relationship between clinically assessed left ventricular ejection fraction (LVEF) and survival in a large, heterogeneous…”
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Clinical outcomes of a genomic screening program for actionable genetic conditions by Buchanan, Adam H., Lester Kirchner, H., Schwartz, Marci L. B., Kelly, Melissa A., Schmidlen, Tara, Jones, Laney K., Hallquist, Miranda L. G., Rocha, Heather, Betts, Megan, Schwiter, Rachel, Butry, Loren, Lazzeri, Amanda L., Frisbie, Lauren R., Rahm, Alanna Kulchak, Hao, Jing, Willard, Huntington F., Martin, Christa L., Ledbetter, David H., Williams, Marc S., Sturm, Amy C.

“…Purpose Three genetic conditions—hereditary breast and ovarian cancer syndrome, Lynch syndrome, and familial hypercholesterolemia—have tier 1 evidence for…”
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Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury by Bucaloiu, Ion D, Kirchner, H Lester, Norfolk, Evan R, Hartle, 2nd, James E, Perkins, Robert M

“…Acute kidney injury increases mortality risk among those with established chronic kidney disease. In this study we used a propensity score-matched cohort…”
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The Geisinger MyCode community health initiative: an electronic health record–linked biobank for precision medicine research by Carey, David J., Fetterolf, Samantha N., Davis, F. Daniel, Faucett, William A., Kirchner, H. Lester, Mirshahi, Uyenlinh, Murray, Michael F., Smelser, Diane T., Gerhard, Glenn S., Ledbetter, David H.

“…Purpose: Geisinger Health System (GHS) provides an ideal platform for Precision Medicine. Key elements are the integrated health system, stable patient…”
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Transition to Dolutegravir Is Associated With an Increase in the Rate of Body Mass Index Change in a Cohort of Virally Suppressed Adolescents by Thivalapill, Neil, Simelane, Tandzile, Mthethwa, Nobuhle, Dlamini, Sandile, Lukhele, Bhekumusa, Okello, Velephi, Kirchner, H Lester, Mandalakas, Anna M, Kay, Alexander W

“…BACKGROUNDAntiretroviral therapy (ART) regimens that contain dolutegravir (DTG) have been associated with increases in body mass index (BMI) in adults…”
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Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease by Dewey, Frederick E, Gusarova, Viktoria, O’Dushlaine, Colm, Gottesman, Omri, Trejos, Jesus, Hunt, Charleen, Van Hout, Cristopher V, Habegger, Lukas, Buckler, David, Lai, Ka-Man V, Leader, Joseph B, Murray, Michael F, Ritchie, Marylyn D, Kirchner, H. Lester, Ledbetter, David H, Penn, John, Lopez, Alexander, Borecki, Ingrid B, Overton, John D, Reid, Jeffrey G, Carey, David J, Murphy, Andrew J, Yancopoulos, George D, Baras, Aris, Gromada, Jesper, Shuldiner, Alan R

“…This study showed an association of loss-of-function mutations in ANGPTL4 with low triglyceride levels and protection against coronary artery disease…”
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Electronic health record analysis identifies kidney disease as the leading risk factor for hospitalization in confirmed COVID-19 patients by Oetjens, Matthew T, Luo, Jonathan Z, Chang, Alexander, Leader, Joseph B, Hartzel, Dustin N, Moore, Bryn S, Strande, Natasha T, Kirchner, H Lester, Ledbetter, David H, Justice, Anne E, Carey, David J, Mirshahi, Tooraj

“…Empirical data on conditions that increase risk of coronavirus disease 2019 (COVID-19) progression are needed to identify high risk individuals. We performed a…”
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Trends in Survival After In-Hospital Cardiac Arrest During Nights and Weekends by Ofoma, Uchenna R., Basnet, Suresh, Berger, Andrea, Kirchner, H. Lester, Girotra, Saket, Abella, Benjamin, Anderson, Monique L., Bradley, Steven M., Chan, Paul S., Edelson, Dana P., Churpek, Matthew M., Geocadin, Romergryko, Goldberger, Zachary D., Howard, Patricia K., Kurz, Michael C., Mosesso, Vincent N., Nassar, Boulos, Ornato, Joseph P., Peberdy, Mary Ann, Perman, Sarah M.

“…Survival after in-hospital cardiac arrest (IHCA) is lower during nights and weekends (off-hours) compared with daytime during weekdays (on-hours). As overall…”
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Parsing the Patients of FREEDOM by Blankenship, James C., Kirchner, H. Lester

“…[Display omitted]…”
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Geriatric assessment-derived deficit accumulation and patient-reported treatment burden in older adults with bladder cancer by Garg, Tullika, Frank, Katie, Johns, Alicia, Rabinowitz, Kirstin, Danella, John F, Kirchner, H Lester, Nielsen, Matthew E, McMullen, Carmit K, Murphy, Terrence E, Cohen, Harvey J

“…When a person's workload of healthcare exceeds their resources, they experience treatment burden. At the intersection of cancer and aging, little is known…”
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Correlates of adolescent sleep time and variability in sleep time: The role of individual and health related characteristics by Moore, Melisa, Kirchner, H. Lester, Drotar, Dennis, Johnson, Nathan, Rosen, Carol, Redline, Susan

“…Abstract Objectives Adolescents are predisposed to short sleep duration and irregular sleep patterns due to certain host characteristics (e.g., age, pubertal…”
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Genome-wide association study of neck circumference identifies sex-specific loci independent of generalized adiposity by Liu, Yaowu, Zhang, Xiaoyu, Lee, Jiwon, Smelser, Diane, Cade, Brian, Chen, Han, Zhou, Hufeng, Kirchner, H. Lester, Lin, Xihong, Mukherjee, Sutapa, Hillman, David, Liu, Ching-Ti, Redline, Susan, Sofer, Tamar

“…Background/objectives Neck circumference, an index of upper airway fat, has been suggested to be an important measure of body-fat distribution with unique…”
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Perioperative diltiazem or nitroglycerin in on-pump coronary artery bypass: A systematic review and network meta-analysis by Hu, Yirui, Yang, Xinbei, Zhang, Li, Wu, Xianren, Liu, Anastasia Yian, Boscarino, Joseph A, Kirchner, H Lester, Casale, Alfred S, Zhang, Xiaopeng

“…Arterial graft spasm is a severe complication after coronary artery bypass graft (CABG). Among numerous potential antispasmodic agents, systemic application of…”
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Atrial appendage closure is associated with increased risk for postoperative atrial fibrillation by Shuhaiber, Jeffrey H, Abbas, Mostafa, Morland, Thomas, Kirchner, H. Lester, El-Manzalawy, Yasser

“…Objectives This study aims to examine the relationship between left atrial appendage closure (LAAC) and post-operative atrial fibrillation (POAF) in cardiac…”
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Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease by Peloso, Gina M, Nomura, Akihiro, Khera, Amit V, Chaffin, Mark, Won, Hong-Hee, Ardissino, Diego, Danesh, John, Schunkert, Heribert, Wilson, James G, Samani, Nilesh, Erdmann, Jeanette, McPherson, Ruth, Watkins, Hugh, Saleheen, Danish, McCarthy, Shane, Teslovich, Tanya M, Leader, Joseph B, Lester Kirchner, H, Marrugat, Jaume, Nohara, Atsushi, Kawashiri, Masa-Aki, Tada, Hayato, Dewey, Frederick E, Carey, David J, Baras, Aris, Kathiresan, Sekar

“…Background Familial hypobetalipoproteinemia is a genetic disorder caused by rare protein-truncating variants (PTV) in the gene encoding APOB (apolipoprotein…”
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