Search Results - "Lester, HA"

Allosteric control of gating and kinetics at P2X(4) receptor channels by Khakh, B S, Proctor, W R, Dunwiddie, T V, Labarca, C, Lester, H A

“…The CNS abundantly expresses P2X receptor channels for ATP; of these the most widespread in the brain is the P2X(4) channel. We show that ivermectin (IVM) is a…”
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State-dependent cross-inhibition between transmitter-gated cation channels by Khakh, Baljit S, Zhou, Xiaoping, Sydes, Jason, Galligan, James J, Lester, Henry A

“…Transmitter-gated cation channels are detectors of excitatory chemical signals at synapses in the nervous system. Here we show that structurally distinct α3β4…”
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Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability by Henderson, Brandon J, Wall, Teagan R, Henley, Beverley M, Kim, Charlene H, McKinney, Sheri, Lester, Henry A

“…Understanding why the quit rate among smokers of menthol cigarettes is lower than non-menthol smokers requires identifying the neurons that are altered by…”
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An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor by Charnet, P, Labarca, C, Leonard, R J, Vogelaar, N J, Czyzyk, L, Gouin, A, Davidson, N, Lester, H A

“…The binding site for an open-channel blocker, QX-222, at mouse muscle nicotinic acetylcholine receptors was probed using site-directed mutagenesis, oocyte…”
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Cis - trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel by Lester, Henry A, Dougherty, Dennis A, Lee, Lori W, Broadhurst, R. William, Lummis, Sarah C. R, Beene, Darren L

“…5-Hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening…”
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TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus by Hurtado-Zavala, Joaquin I., Ramachandran, Binu, Ahmed, Saheeb, Halder, Rashi, Bolleyer, Christiane, Awasthi, Ankit, Stahlberg, Markus A., Wagener, Robin J., Anderson, Kristin, Drenan, Ryan M., Lester, Henry A., Miwa, Julie M., Staiger, Jochen F., Fischer, Andre, Dean, Camin

“…TRPV1 is an ion channel activated by heat and pungent agents including capsaicin, and has been extensively studied in nociception of sensory neurons. However,…”
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Cys-loop receptors: new twists and turns by Lester, Henry A., Dibas, Mohammed I., Dahan, David S., Leite, John F., Dougherty, Dennis A.

“…New hypotheses and predictions have arisen from recent work revealing atomic-scale or near-atomic-scale structures of receptors in the ‘Cys-loop’ superfamily…”
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Assembly of alpha 4 beta 2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons by Nashmi, R, Dickinson, ME, McKinney, S, Jareb, M, Labarca, C, Fraser, SE, Lester, HA

“…Fura-2 recording of Ca super(2+) influx was used to show that incubation in 1 mu M nicotine (2-6 d) upregulates several pharmacological components of…”
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GABA Transporter Deficiency Causes Tremor, Ataxia, Nervousness, and Increased GABA-Induced Tonic Conductance in Cerebellum by Chiu, Chi-Sung, Brickley, Stephen, Jensen, Kimmo, Southwell, Amber, Mckinney, Sheri, Cull-Candy, Stuart, Mody, Istvan, Lester, Henry A

“…GABA transporter subtype 1 (GAT1) knock-out (KO) mice display normal reproduction and life span but have reduced body weight (female, -10%; male, -20%) and…”
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Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease by Jankowsky, Joanna L, Slunt, Hilda H, Gonzales, Victoria, Savonenko, Alena V, Wen, Jason C, Jenkins, Nancy A, Copeland, Neal G, Younkin, Linda H, Lester, Henry A, Younkin, Steven G, Borchelt, David R

“…Background The proteases (secretases) that cleave amyloid- beta (A beta ) peptide from the amyloid precursor protein (APP) have been the focus of considerable…”
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Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and In Vivo Myelination by Neusch, Clemens, Rozengurt, Nora, Jacobs, Russell E, Lester, Henry A, Kofuji, Paulo

“…To understand the cellular and in vivo functions of specific K(+) channels in glia, we have studied mice with a null mutation in the weakly inwardly rectifying…”
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Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT3A) and Nicotinic Acetylcholine Receptors:  The Anomalous Binding Properties of Nicotine by Beene, Darren L, Brandt, Gabriel S, Zhong, Wenge, Zacharias, Niki M, Lester, Henry A, Dougherty, Dennis A

“…A series of tryptophan analogues has been introduced into the binding site regions of two ion channels, the ligand-gated nicotinic acetylcholine and serotonin…”
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A Unified View of the Role of Electrostatic Interactions in Modulating the Gating of Cys Loop Receptors by Xiu, Xinan, Hanek, Ariele P., Wang, Jinti, Lester, Henry A., Dougherty, Dennis A.

“…In the Cys loop superfamily of ligand-gated ion channels, a global conformational change, initiated by agonist binding, results in channel opening and the…”
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D 2 Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 (RGS9-2) via the RGS9 DEP Domain, and RGS9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways by Kovoor, Abraham, Seyffarth, Petra, Ebert, Jana, Barghshoon, Sami, Chen, Ching-Kang, Schwarz, Sigrid, Axelrod, Jeffrey D., Cheyette, Benjamin N. R., Simon, Melvin I., Lester, Henry A., Schwarz, Johannes

“…Regulator of G-protein signaling 9-2 (RGS9-2), a member of the RGS family of Gα GTPase accelerating proteins, is expressed specifically in the striatum, which…”
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Genetic Inactivation of an Inwardly Rectifying Potassium Channel (Kir4.1 Subunit) in Mice: Phenotypic Impact in Retina by Kofuji, Paulo, Ceelen, Paul, Zahs, Kathleen R, Surbeck, Leslie W, Lester, Henry A, Newman, Eric A

“…The inwardly rectifying potassium channel Kir4.1 has been suggested to underlie the principal K(+) conductance of mammalian Müller cells and to participate in…”
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CNS localization of neuronal nicotinic receptors by Nashmi, Raad, Lester, Henry A

“…Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop superfamily of pentameric ligand-gated ion channels, which include GABA (A and C),…”
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International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels by Gutman, George A, Chandy, K George, Adelman, John P, Aiyar, Jayashree, Bayliss, Douglas A, Clapham, David E, Covarriubias, Manuel, Desir, Gary V, Furuichi, Kiyoshi, Ganetzky, Barry, Garcia, Maria L, Grissmer, Stephan, Jan, Lily Y, Karschin, Andreas, Kim, Donghee, Kuperschmidt, Sabina, Kurachi, Yoshihisa, Lazdunski, Michel, Lesage, Florian, Lester, Henry A, McKinnon, David, Nichols, Colin G, O'Kelly, Ita, Robbins, Jonathan, Robertson, Gail A, Rudy, Bernardo, Sanguinetti, Michael, Seino, Susumu, Stuehmer, Walter, Tamkun, Michael M, Vandenberg, Carol A, Wei, Aguan, Wulff, Heike, Wymore, Randy S

“…This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which…”
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Intrinsic Noise in Cultured Hippocampal Neurons: Experiment and Modeling by Diba, Kamran, Lester, Henry A, Koch, Christof

“…Ion channels open and close stochastically. The fluctuation of these channels represents an intrinsic source of noise that affects the input-output properties…”
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Using Physical Chemistry To Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic Acetylcholine Receptor by Cashin, Amanda L, Petersson, E. James, Lester, Henry A, Dougherty, Dennis A

“…The binding of three distinct agonistsacetylcholine (ACh), nicotine, and epibatidineto the nicotinic acetylcholine receptor has been probed using unnatural…”
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From Ab initio Quantum Mechanics to Molecular Neurobiology: A cation-π Binding Site in the Nicotinic Receptor by Zhong, Wenge, Gallivan, Justin P., Zhang, Yinong, Li, Lintong, Lester, Henry A., Dougherty, Dennis A.

“…The nicotinic acetylcholine receptor is the prototype ligand-gated ion channel. A number of aromatic amino acids have been identified as contributing to the…”
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