Search Results - "Lesslie, Michael"

Electron–Rotor Interaction in Organic–Inorganic Lead Iodide Perovskites Discovered by Isotope Effects by Gong, Jue, Yang, Mengjin, Ma, Xiangchao, Schaller, Richard D, Liu, Gang, Kong, Lingping, Yang, Ye, Beard, Matthew C, Lesslie, Michael, Dai, Ying, Huang, Baibiao, Zhu, Kai, Xu, Tao

“…We report on the carrier–rotor coupling effect in perovskite organic–inorganic hybrid lead iodide (CH3NH3PbI3) compounds discovered by isotope effects…”
Get full text

Cytosine Radical Cations: A Gas‐Phase Study Combining IRMPD Spectroscopy, UVPD Spectroscopy, Ion–Molecule Reactions, and Theoretical Calculations by Lesslie, Michael, Lawler, John T., Dang, Andy, Korn, Joseph A., Bím, Daniel, Steinmetz, Vincent, Maître, Philippe, Tureček, Frantisek, Ryzhov, Victor

“…The radical cation of cytosine (Cyt.+) is generated by dissociative oxidation from a ternary CuII complex in the gas phase. The radical cation is characterized…”
Get full text

Development and validation of a HILIC–MS/MS method for quantification of decitabine in human plasma by using lithium adduct detection by Hua, Wenyi, Ierardi, Thomas, Lesslie, Michael, Hoffman, Brian T., Mulvana, Daniel

“…•The assay demonstrated high sensitivity (0.44–440pg injected on column) with a simple protein precipitation extraction.•HILIC separation of anomers and two…”
Get full text

Near-UV Water Splitting by Cu, Ni, and Co Complexes in the Gas Phase by Dang, Andy, Shaffer, Christopher J, Bím, Daniel, Lawler, John, Lesslie, Michael, Ryzhov, Victor, Tureček, František

“…(2,2′-Bipyridine)­MO+ ions (M = Cu, Ni, Co) were generated by collision-induced dissociation and near-UV photodissociation of readily available…”
Get full text

Investigations of Biologically Relevant Free Radicals Utilizing Novel Gas-Phase Analytical Techniques by Lesslie, Michael

“…The investigation of gas-phase radical cations as a method of modeling and exploring the fundamental chemical characteristics of radicals found in biological…”
Get full text

Lean Stability Approaches in Pharmaceutical Product Development, Registration, and Post-marketing CMC Change Management; Industry Survey Insights by Pulliam, Donnie, McMahon, Megan, Regler, Brian P., Smith, Susan, Martin, Cheryl, Babayan, Yelizaveta, Hoaglund-Hyzer, Cherokee, Lesslie, Michael, Qiu, Fenghe, Adamec, Eric, Wang, Jin, Forenzo, Pat, Wannere, Chaitanya S., Zhuang, Ping, Gruenig, Lars

“…Purpose This paper summarizes results from a recent pharmaceutical industry survey to understand the adoption status of science- and risk-based approaches in…”
Get full text

The formation of resonance-stabilized sulfur-based radical cations and their gas-phase reactivity by Lesslie, Michael, Meyer, Julie A., Osburn, Sandra, Otun, Sheriff, Ryzhov, Victor

“…•Sulfur-based radical cations of 10 organic molecules were formed by two methods.•Method 1: CID of ternary copper complexes; Method 2: CID of protonated…”
Get full text

Hydrogen atom transfer in metal ion complexes of the glutathione thiyl radical by Lesslie, Michael, Lau, Justin Kai-Chi, Pacheco, Gardenia, Lawler, John T., Michael Siu, K.W., Hopkinson, Alan C., Ryzhov, Victor

“…[Display omitted] •Metal ion complexes of glutathione thiyl radical are generated in the gas phase.•Isomerization to Cα-based radical species is studied via…”
Get full text

Lean Stability Case Studies—Leveraging Science- and Risk-Based Approaches to Enable Meaningful Phase Specific Pharmaceutical Stability Strategies by Adamec, Eric, Babayan, Yelizaveta, Catacchio, Bruno, Coon, Angela, Dill, Allison, Fu, Mingkun, Gruenig, Lars, Hyzer, Cherokee Hoaglund, Lesslie, Michael, McMahon, Megan, Pulliam, Donnie, Qiu, Fenghe, Regler, Brian P., Szymulanska-Ramamurthy, Karina, Timpano, Robert, Wannere, Chait

“…Purpose Lean stability is a science- and risk-based initiative which utilizes the enhanced understanding of drug substance and drug product physical and…”
Get full text

Electron–Rotor Interaction in Organic–Inorganic Lead Iodide Perovskites Discovered by Isotope Effects by Gong, Jue, Yang, Mengjin, Ma, Xiangchao, Schaller, Richard D., Liu, Gang, Kong, Lingping, Yang, Ye, Beard, Matthew C., Lesslie, Michael, Dai, Ying, Huang, Baibiao, Zhu, Kai, Xu, Tao

“…We report on the carrier-rotor coupling effect in perovskite organic-inorganic hybrid lead iodide (CH3NH3PbI3) compounds discovered by isotope effects…”
Get full text

The effects of intramolecular hydrogen bonding on the reactivity of phenoxyl radicals in model systems by Lesslie, Michael, Piatkivskyi, Andrii, Lawler, John, Helgren, Travis R., Osburn, Sandra, O’Hair, Richard A.J., Ryzhov, Victor

“…•Gas-phase reactivity of phenoxyl radical cations of aromatic nitrogen bases is studied.•Reactivity towards NO and C3H7SH decreases as N+-H⋯O distance…”
Get full text

Alkali-Metal-Ion-Assisted Hydrogen Atom Transfer in the Homocysteine Radical by Lesslie, Michael, Lau, Justin Kai-Chi, Lawler, John T., Siu, K. W. Michael, Oomens, Jos, Berden, Giel, Hopkinson, Alan C., Ryzhov, Victor

“…Intramolecular hydrogen atom transfer (HAT) was examined in homocysteine (Hcy) thiyl radical/alkali metal ion complexes in the gas phase by combination of…”
Get full text

Development of a sensitive and fast UHPLC-MS/MS method for determination of clopidogrel, clopidogrel acid and clopidogrel active metabolite H4 in human plasma by Hua, Wenyi, Lesslie, Michael, Hoffman, Brian T, Binns, Christopher, Mulvana, Daniel

“…Quantitation of CAM H4 in biological matrix has been a challenge due to low concentrations, instability and the existence of four CAM diastereomers…”
Get full text

Gas-Phase Tyrosine-to-cysteine Radical Migration in Model Systems by Lesslie, Michael, Osburn, Sandra, van Stipdonk, Michael J, Ryzhov, Victor

“…Radical migration, both intramolecular and intermolecular, from the tyrosine phenoxyl radical Tyr(O•) to the cysteine radical Cys(S•) in model peptide systems…”
Get full text

Cysteine Radical/Metal Ion Adducts: A Gas-Phase Structural Elucidation and Reactivity Study by Lesslie, Michael, Lau, Justin Kai-Chi, Lawler, John T., Siu, K. W. Michael, Steinmetz, Vincent, Maître, Philippe, Hopkinson, Alan C., Ryzhov, Victor

“…The formation and investigation of sulfur‐based cysteine radicals cationized by a group 1A metal ion or Ag+ in the gas phase are reported. Gas‐phase…”
Get full text