Search Results - "Lessie, Matthew D"

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication by Aggarwal, Priya, Lessie, Matthew D, Lin, Douglas I, Pontano, Laura, Gladden, Andrew B, Nuskey, Beth, Goradia, Ami, Wasik, Mariusz A, Klein-Szanto, Andres J P, Rustgi, Anil K, Bassing, Craig H, Diehl, J Alan

“…Deregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative splicing, and gene amplification. Although cancer-derived cyclin D1…”
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Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis by Lin, D I, Lessie, M D, Gladden, A B, Bassing, C H, Wagner, K U, Diehl, J A

“…Cyclin D1 levels are maintained at steady state by phosphorylation-dependent nuclear export and polyubiquitination by SCF FBX4-αB crystallin . Inhibition of…”
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