Search Results - "Lessi, Francesca"
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Identification of New Potential Prognostic and Predictive Markers in High-Grade Osteosarcoma Using Whole Exome Sequencing
Published in International journal of molecular sciences (01-06-2023)“…Conventional high-grade osteosarcoma (OS) is the most common primary cancer of bone and it typically affects the extremities of adolescents. OS has a complex…”
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2
Molecular characterization of low grade and high grade bladder cancer
Published in PloS one (16-01-2019)“…Bladder cancer (BC) is the 9th most common cancer diagnosis worldwide. Low grade (LG) represents 70% of all BCs, characterized by recurrence and rare ability…”
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3
Sedoheptulose Kinase SHPK Expression in Glioblastoma: Emerging Role of the Nonoxidative Pentose Phosphate Pathway in Tumor Proliferation
Published in International journal of molecular sciences (26-05-2022)“…Glioblastoma (GBM) is the most common form of malignant brain cancer and is considered the deadliest human cancer. Because of poor outcomes in this disease,…”
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4
CXCL12α/SDF‐1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals
Published in EMBO molecular medicine (01-08-2017)“…The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter‐cellular signals involved…”
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5
Laser Capture Microdissection and RNA-Seq Analysis: High Sensitivity Approaches to Explain Histopathological Heterogeneity in Human Glioblastoma FFPE Archived Tissues
Published in Frontiers in oncology (07-06-2019)“…Laser capture microdissection (LCM) coupled with RNA-seq is a powerful tool to identify genes that are differentially expressed in specific histological tumor…”
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Innovative Approach to Isolate and Characterize Glioblastoma Circulating Tumor Cells and Correlation with Tumor Mutational Status
Published in International journal of molecular sciences (01-06-2023)“…Circulating tumor cells (CTCs) are one of the most important causes of tumor recurrence and distant metastases. Glioblastoma (GBM) has been considered…”
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Whole-exome analysis in osteosarcoma to identify a personalized therapy
Published in Oncotarget (06-10-2017)“…Osteosarcoma is the most common pediatric primary non-hematopoietic bone tumor. Survival of these young patients is related to the response to chemotherapy and…”
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Metabolic-imaging of human glioblastoma live tumors: A new precision-medicine approach to predict tumor treatment response early
Published in Frontiers in oncology (05-09-2022)“…Background Glioblastoma (GB) is the most severe form of brain cancer, with a 12-15 month median survival. Surgical resection, temozolomide (TMZ) treatment, and…”
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Mouse mammary tumour virus-like env nucleotide and p14 signal peptide are present in feline mammary carcinomas, but not in neoplastic or dysplastic canine mammary lesions
Published in PloS one (24-07-2018)“…Mouse mammary tumour virus-like (MMTV-like) is suspected to be involved in human breast cancer and it has been hypothesized that companion animals might have a…”
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10
Loss of c-KIT expression in thyroid cancer cells
Published in PloS one (16-03-2017)“…Papillary thyroid carcinoma is the most frequent histologic type of thyroid tumor. Few studies investigated the role of c-KIT expression in thyroid tumors,…”
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11
Titanium-coated polypropylene mesh as innovative bioactive material in conservatives mastectomies and pre-pectoral breast reconstruction
Published in Bioactive materials (01-12-2021)“…Breast reconstruction is rapidly evolving, thanks to the growing acceptance of synthetic meshes as innovative biomaterials. 276 patients undergoing mastectomy…”
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Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells
Published in Cell adhesion & migration (01-01-2021)“…MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the…”
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Diffuse bone and soft tissue angiomatosis with GNAQ mutation
Published in Pathology international (01-07-2020)“…We describe a unique case of skeletal and extraskeletal angiomatosis complicated by Kasabach–Merritt syndrome. The patient was a 3‐year‐old boy, who presented…”
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Exploring Regorafenib Responsiveness and Uncovering Molecular Mechanisms in Recurrent Glioblastoma Tumors through Longitudinal In Vitro Sampling
Published in Cells (Basel, Switzerland) (01-03-2024)“…Glioblastoma, a deadly brain tumor, shows limited response to standard therapies like temozolomide (TMZ). Recent findings from the REGOMA trial underscore a…”
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15
Presence of a mouse mammary tumour virus-like in feline lymphomas: a preliminary study
Published in Infectious agents and cancer (23-06-2022)“…Abstract The mouse mammary tumour virus (MMTV) is implicated in the aetiology of murine mammary carcinomas and a variant of it, the type B leukemogenic virus,…”
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Next generation sequencing technologies for a successful diagnosis in a cold case of Leigh syndrome
Published in BMC neurology (20-07-2018)“…Leigh Syndrome (LS, OMIM 256000) is an early-onset, progressive neurodegenerative disorder characterized by broad clinical and genetic heterogeneity; it is the…”
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Pathological Features and Molecular Phenotype of MMTV Like-Positive Feline Mammary Carcinomas
Published in Animals (Basel) (27-09-2021)“…In the last few years MMTV-like nucleotide sequences were detected in some feline and canine mammary tumours. Due to the confirmed role of cats in the…”
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18
Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor
Published in Acta neuropathologica communications (25-12-2022)“…Regeneration of the neuromuscular junction (NMJ) leverages on extensive exchange of factors released from motor axon terminals (MATs), muscle fibers and…”
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Monoallelic expression in melanoma
Published in Journal of translational medicine (05-04-2019)“…Monoallelic expression (MAE) is a frequent genomic phenomenon in normal tissues, however its role in cancer is yet to be fully understood. MAE is defined as…”
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Single-Cell Molecular Characterization to Partition the Human Glioblastoma Tumor Microenvironment Genetic Background
Published in Cells (Basel, Switzerland) (26-03-2022)“…Glioblastoma (GB) is a devastating primary brain malignancy. The recurrence of GB is inevitable despite the standard treatment of surgery, chemotherapy, and…”
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