Clinical, ultrasound and anatomopathological concordance of thyroid nodules in Kinshasa: a cross-sectional study

The European Thyroid Association Thyroid Imaging Data and Reporting Systems (EU-TIRADS) is widely used in the risk stratification of thyroid nodule malignancy. However, data on the subject in Sub-Saharan Africa are limited. The objective of this study is to evaluate the clinical, sonographic and his...

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Published in:	BMC endocrine disorders Vol. 24; no. 1; pp. 174 - 6
Main Authors:	Kumbu, Jacques Mbizi, Nkodila, Aliocha Natuhoyila, Kuzeye, Jules Nakafwako, Minouche, Cynthia Bokumba, Molua, Antoine Aundu, Mbongo, Angel Tanzia, Bisuta, Serge Fueza, Lessenge, Jacquie Bonsuani, Kisile, Olive Mikwo, Sitwaminya, Renault, Beya, Francois Kabongo, Ali, Cathy Risasi, Nsadi, Berthier Fwene, Mbaya, Malik Kayembe, Mpa, Olivier Nzankulu, Omba, Alain Wembolwa, Tsasa, Erick Mbuku, Tsongo, Sosthene Vululi, Kiabaka, Honoré Yambula, Makelele, Raoul Vindu, Lelo, Michel Tshikwela, Mukaya, Jean Tshibola
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 02-09-2024 BioMed Central BMC
Subjects:	Adult Calcification Cancer Clinical Score Clinics Concordance Cross-Sectional Studies Democratic Republic of Congo Democratic Republic of the Congo - epidemiology Diagnosis EU-TIRADS Female Follow-Up Studies Goiter Histopathology Humans Male Malignancy Middle Aged Morphology Nodules Patients Prognosis Software Thyroid cancer Thyroid gland Thyroid Gland - diagnostic imaging Thyroid Gland - pathology Thyroid Neoplasms - diagnostic imaging Thyroid Neoplasms - epidemiology Thyroid Neoplasms - pathology Thyroid Nodule - diagnostic imaging Thyroid Nodule - pathology Ultrasonic imaging Ultrasonography - methods Ultrasound Democratic Republic of the Congo EU-TIRADS Histopathology Clinical Score Concordance Democratic Republic of Congo
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Summary:	The European Thyroid Association Thyroid Imaging Data and Reporting Systems (EU-TIRADS) is widely used in the risk stratification of thyroid nodule malignancy. However, data on the subject in Sub-Saharan Africa are limited. The objective of this study is to evaluate the clinical, sonographic and histopathological concordance of thyroid nodules in the diagnosis of thyroid cancer. This was an analytical cross-sectional study that examined the clinical, ultrasound and pathological data of 61 patients from 4 hospitals in the city province of Kinshasa over a period of 24 months, from June 01, 2020 to May 31, 2022. Of the 61 patients, their mean age was 47.38 ± 8.8 years. The mean clinical score of the patients was 3.4 ± 0.84 with the extremes ranging from 1 to 5. The majority of the patients were classified as having an intermediate risk, ie 85.2% of the cases. It was noted that 41% of the nodules had a high risk according to the EU-TIRADS score and 8.2% of the nodules were malignant after histopathological analysis. The ROC curves reported at the diagnosis of malignancy show an area under the curve of 0.709 with 95% CI (0.486-0.931), a Youden index of 0.769 for the clinical score, and an area under the curve of 0.830 with 95% CI (0.605-0.995), a Youden index of 0.772 for the EU-TIRADS score. In a low-income country, a well-performed thyroid ultrasound and the well-applied clinical score could be an important tool in the selection of thyroid nodules suspected of malignancy and requiring histopathological examination to avoid excessive acts in the patient.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1472-6823 1472-6823
DOI:	10.1186/s12902-024-01710-5