Search Results - "Lessene, G"

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1 by Teh, T-C, Nguyen, N-Y, Moujalled, D M, Segal, D, Pomilio, G, Rijal, S, Jabbour, A, Cummins, K, Lackovic, K, Blombery, P, Thompson, E, Ekert, P G, Lessene, G, Glaser, S P, Huang, D C S, Roberts, A W, Guthridge, M A, Wei, A H

“…Targeted therapies are frequently combined with standard cytotoxic drugs to enhance clinical response. Targeting the B-cell lymphoma 2 (BCL-2) family of…”
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Cell death and the mitochondria: therapeutic targeting of the BCL‐2 family‐driven pathway by Roy, M J, Vom, A, Czabotar, P E, Lessene, G

“…The principal biological role of mitochondria is to supply energy to cells; although intriguingly, evolution has bestowed another essential function upon these…”
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HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death by Jacobsen, A V, Lowes, K N, Tanzer, M C, Lucet, I S, Hildebrand, J M, Petrie, E J, van Delft, M F, Liu, Z, Conos, S A, Zhang, J-G, Huang, D C S, Silke, J, Lessene, G, Murphy, J M

“…Necroptosis is a caspase-independent form of regulated cell death that has been implicated in the development of a range of inflammatory, autoimmune and…”
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Effects of modulators of Ca(2+)-activated, intermediate-conductance potassium channels on motility of the rat small intestine, in vivo by Ferens, D, Baell, J, Lessene, G, Smith, J E, Furness, J B

“…The movements of the intestine shift between different motor patterns, including between propulsion and mixing, but there is little information concerning…”
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Dissecting the RIPK3/MLKL necroptotic molecular switch by Davies, K., Meng, Y., Fitzgibbon, C., Young, S., Garnish, S., Horne, C., Luo, C., Garnier, J., Liang, L., Cowan, A., Samson, A., Lessene, G., Sandow, J., Czabotar, P., Murphy, J.

“…Abstract only…”
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Effects of modulators of Ca2+‐activated, intermediate‐conductance potassium channels on motility of the rat small intestine, in vivo by Ferens, D., Baell, J., Lessene, G., Smith, J. E., Furness, J. B.

“…The movements of the intestine shift between different motor patterns, including between propulsion and mixing, but there is little information concerning…”
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A Concise Total Synthesis of Naamidine A by Aberle, Nicholas S, Lessene, Guillaume, Watson, Keith G

“…A total synthesis of naamidine A is reported. Key benefits of the described pathway include its brevity, its synthetic ease, and its flexibility with respect…”
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Diazonamide Synthesis Studies:  Use of Negishi Coupling to Fashion Diazonamide-Related Biaryls with Defined Axial Chirality by Feldman, Ken S, Eastman, Kyle J, Lessene, Guillaume

“…The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl…”
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Effects of modulators of Ca super(2+)-activated, intermediate-conductance potassium channels on motility of the rat small intestine, in vivo by Ferens, D, Baell, J, Lessene, G, Smith, JE, Furness, J B

“…Abstract The movements of the intestine shift between different motor patterns, including between propulsion and mixing, but there is little information…”
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Effects of modulators of Ca 2+ ‐activated, intermediate‐conductance potassium channels on motility of the rat small intestine, in vivo by Ferens, D., Baell, J., Lessene, G., Smith, J. E., Furness, J. B.

“…Abstract  The movements of the intestine shift between different motor patterns, including between propulsion and mixing, but there is little information…”
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The Tyr-Kinase Inhibitor AG879, that Blocks the ETK-PAK1 Interaction, Suppresses the RAS-induced PAK1 Activation and Malignant Transformation by He, Hong, Hirokawa, Yumiko, Gazit, Aviv, Yamashita, Yoshihiro, Mano, Hiroyuki, Kawakami, Yuko, Kawakami, Toshiaki, Hsieh, Ching-Yi, Kung, Hsing-Jien, Lessene, Guillaume, Baell, Jonathan, Levitzki, Alexander, Maruta, Hiroshi

“…AG 879 has been widely used as a Tyr kinase inhibitor specific for ErbB2 and FLK-1, a VEGF receptor. The IC50 for both ErbB2 and FLK-1 is around 1 mM. AG 879,…”
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Selective electrochemical synthesis and reactivity of functional benzylic fluorosilylsynthons by Clavel, Philippe, Lessene, Guillaume, Biran, Claude, Bordeau, Michel, Roques, Nicolas, Trévin, Stéphane, Montauzon, Dominique de

“…Electrochemical reductive silylation of meta-(trifluoromethyl)arenes by the sacrificial anode technique selectively led to…”
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Magnesium bis(diisopropylamide), a useful reagent for regio- and stereoselective synthesis of kinetic silyl enol ethers by Lessène, Guillaume, Tripoli, Régis, Cazeau, Philippe, Biran, Claude, Bordeau, Michel

“…Less highly substituted silyl enol ethers are regiospecifically prepared in high yield, around room temperature under kinetic conditions, from unsymmetrical…”
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Towards the electroreduction of very weak acids by Lessene, Guillaume, Bordeau, Michel, Biran, Claude, de Montauzon, Dominique, Gerval, Jacqueline

“…In order to improve the understanding of the synthesis of electrogenerated bases (EGB), the electrochemical reduction of two weak acids, 2-pyrrolidone (p K…”
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